Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol-Drinking Behavior in Alcohol-Dependent Mice

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

(2015) Nicholas W. Gilpin et al.   BIOLOGICAL PSYCHIATRY

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4

(2015) Ryan Bachtell et al.   CNS & Neurological Disorders-Drug Targets

CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

(2015) Harry L June et al.   NEUROPSYCHOPHARMACOLOGY

Peroxisome Proliferator-Activated Receptorsαandγare Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

(2014) Yuri A. Blednov et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala

(2014) Michal Bajo et al.   BRAIN BEHAVIOR AND IMMUNITY

Biological role of Toll-like receptor-4 in the brain

(2014) Teresa Trotta et al.   JOURNAL OF NEUROIMMUNOLOGY

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

(2014) Yuri A. Blednov et al.   Frontiers in Neuroscience

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence

(2013) Richard L. Bell et al.   ADDICTION BIOLOGY

μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche

(2013) Candice Contet et al.   ADDICTION BIOLOGY

Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype

(2013) S. Alex Marshall et al.   NEUROBIOLOGY OF DISEASE

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

(2012) Liya Qin et al.   Journal of Neuroinflammation

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology?

(2012) Oscar Kurt Bitzer-Quintero et al.   NEURAL PLASTICITY

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

(2011) Yuri A. Blednov et al.   ADDICTION BIOLOGY

Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking

(2011) Serena Stopponi et al.   BIOLOGICAL PSYCHIATRY

Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment

(2011) Yue Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage

(2011) María Pascual et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice

(2011) Yue Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of β-Amino Alcohol Derivatives That Inhibit Toll-like Receptor 4 Mediated Inflammatory Response as Potential Antiseptics

(2011) Sherry A. Chavez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Binge alcohol drinking is associated with GABAA  2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4

(2010) Douglas E. Bevan et al.   ACS Medicinal Chemistry Letters

Systemic Administration of Lipopolysaccharide Induces Cyclooxygenase-2 Immunoreactivity in Endothelium and Increases Microglia in the Mouse Hippocampus

(2009) Dae Won Chung et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol

(2009) S. Fernandez-Lizarbe et al.   JOURNAL OF IMMUNOLOGY

Chronic Mild Stress (CMS) in Mice: Of Anhedonia, ‘Anomalous Anxiolysis’ and Activity

(2009) Martin C. Schweizer et al.   PLoS One

Increased MCP-1 and microglia in various regions of the human alcoholic brain

(2007) Jun He et al.   EXPERIMENTAL NEUROLOGY