Designing nanomedicine for immuno-oncology

Breaking Down the Barriers to Precision Cancer Nanomedicine

(2017) Christina von Roemeling et al.   TRENDS IN BIOTECHNOLOGY

Moving Programmed Death-1 Inhibitors to the Front Lines in Non–Small-Cell Lung Cancer

(2016) Justin F. Gainor   JOURNAL OF CLINICAL ONCOLOGY

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

(2016) Roy S Herbst et al.   LANCET

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Biomimetic proteolipid vesicles for targeting inflamed tissues

(2016) R. Molinaro et al.   NATURE MATERIALS

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

(2016) Ouajdi Felfoul et al.   Nature Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer

(2016) Pavan P. Adiseshaiah et al.   Nature Reviews Clinical Oncology

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma

(2016) Paul T. Nghiem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tailoring nanoparticle designs to target cancer based on tumor pathophysiology

(2016) Edward A. Sykes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy

(2016) Kazuhide Sato et al.   Science Translational Medicine

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

(2016) Alexandre Carpentier et al.   Science Translational Medicine

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

(2016) Hendrik B. Sager et al.   Science Translational Medicine

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

In This Issue

(2016)   Cancer Discovery

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes

(2016) Yaqing Qie et al.   Scientific Reports

Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma

(2015) Yuanyuan Guo et al.   ACS Nano

Remodeling Tumor Vasculature to Enhance Delivery of Intermediate-Sized Nanoparticles

(2015) Wen Jiang et al.   ACS Nano

Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor

(2015) Tara Arvedson et al.   BIODRUGS

Immunoengineering: How Nanotechnology Can Enhance Cancer Immunotherapy

(2015) Michael S. Goldberg   CELL

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

(2015) P. H. Lizotte et al.   Nature Nanotechnology

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

(2015) Stephen M. Ansell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

(2015) Rikke B. Holmgaard et al.   Cell Reports

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

(2014) Carl D. Walkey et al.   ACS Nano

Targeting fibronectins of glioma extracellular matrix by CLT1 peptide-conjugated nanoparticles

(2014) Bo Zhang et al.   BIOMATERIALS

Nanopharmaceuticals (part 1): products on the market

(2014) Volkmar Weissig et al.   International Journal of Nanomedicine

Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

(2014) J. M. Pitt et al.   JOURNAL OF IMMUNOLOGY

Imaging macrophages with nanoparticles

(2014) Ralph Weissleder et al.   NATURE MATERIALS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology

(2013) Jinbin Liu et al.   Materials Today

Nanoengineering approaches to the design of artificial antigen-presenting cells

(2013) Joel C Sunshine et al.   Nanomedicine

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Cancer Nanomedicine: From Drug Delivery to Imaging

(2013) E. K.-H. Chow et al.   Science Translational Medicine

Scavenger Receptor Mediated Endocytosis of Silver Nanoparticles into J774A.1 Macrophages Is Heterogeneous

(2012) Hongyun Wang et al.   ACS Nano

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Cellular Constituents of Immune Escape within the Tumor Microenvironment

(2012) S. P. Kerkar et al.   CANCER RESEARCH

Tim-3, a negative regulator of anti-tumor immunity

(2012) Ana Carrizosa Anderson   CURRENT OPINION IN IMMUNOLOGY

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

(2012) Ashley L. St. John et al.   NATURE MATERIALS

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

(2012) Alessandro Parodi et al.   Nature Nanotechnology

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

(2012) Tatiana I Novobrantseva et al.   Molecular Therapy-Nucleic Acids

Nanoparticle Delivery of Cancer Drugs

(2011) Andrew Z. Wang et al.   Annual Review of Medicine

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

(2011) Kai Xiao et al.   BIOMATERIALS

The Evolving War on Cancer

(2011) Daniel A. Haber et al.   CELL

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

(2011) Nam-Hyuk Cho et al.   Nature Nanotechnology

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

(2011) Haiyan Li et al.   Nature Nanotechnology

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging

(2011) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of drugs and nanoparticles to tumors

(2010) Erkki Ruoslahti et al.   JOURNAL OF CELL BIOLOGY

Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain

(2010) Anja Zensi et al.   JOURNAL OF DRUG TARGETING

Anti-CD4-targeted Gold Nanoparticles Induce Specific Contrast Enhancement of Peripheral Lymph Nodes in X-ray Computed Tomography of Live Mice

(2010) Wolfgang Eck et al.   NANO LETTERS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Targeted lipid-coated nanoparticles: Delivery of tumor necrosis factor-functionalized particles to tumor cells

(2009) Sylvia K.E. Messerschmidt et al.   JOURNAL OF CONTROLLED RELEASE

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Design considerations for tumour-targeted nanoparticles

(2009) Hak Soo Choi et al.   Nature Nanotechnology

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein nanoparticles as drug carriers in clinical medicine

(2008) Michael J. Hawkins et al.   ADVANCED DRUG DELIVERY REVIEWS

Particle size-dependent organ distribution of gold nanoparticles after intravenous administration

(2008) Wim H. De Jong et al.   BIOMATERIALS

Therapeutic Nanoparticles for Drug Delivery in Cancer

(2008) K. Cho et al.   CLINICAL CANCER RESEARCH

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY

Biodegradable Quantum Dot Nanocomposites Enable Live Cell Labeling and Imaging of Cytoplasmic Targets

(2008) Betty Y. S. Kim et al.   NANO LETTERS

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

Monoclonal Antibody Therapy for B-Cell Non-Hodgkin's Lymphoma

(2008) Bruce D. Cheson et al.   NEW ENGLAND JOURNAL OF MEDICINE