Intrinsic Variability Present in Wharton’s Jelly Mesenchymal Stem Cells and T Cell Responses May Impact Cell Therapy

Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium–induced colitis model

(2016) Patricia Fuenzalida et al.   CYTOTHERAPY

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Characterization of bone marrow-derived mesenchymal stem cells in aging

(2015) Natasha Baker et al.   BONE

Comparison between isolation protocols highlights intrinsic variability of human umbilical cord mesenchymal cells

(2015) Fernanda Vieira Paladino et al.   CELL AND TISSUE BANKING

Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population

(2015) Enikő Szabó et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stem cells suppress CD8+T cell-mediated activation by suppressing natural killer group 2, member D protein receptor expression and secretion of prostaglandin E2, indoleamine 2, 3-dioxygenase and transforming growth factor-β

(2014) Mingfen Li et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

(2014) Ying Wang et al.   NATURE IMMUNOLOGY

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

(2014) Juan Carlos Sepúlveda et al.   STEM CELLS

Mesenchymal Stem Cells for Regenerative Therapy: Optimization of Cell Preparation Protocols

(2014) Chiho Ikebe et al.   Biomed Research International

Secretion of immunoregulatory cytokines by mesenchymal stem cells

(2014) Dobroslav Kyurkchiev   World Journal of Stem Cells

CD106 Identifies a Subpopulation of Mesenchymal Stem Cells with Unique Immunomodulatory Properties

(2013) Zhou Xin Yang et al.   PLoS One

Mesenchymal stem cells: a double-edged sword in regulating immune responses

(2012) W Li et al.   CELL DEATH AND DIFFERENTIATION

Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease

(2012) L. M. Tobin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Conditioned Medium from Adipose Tissue-Derived Mesenchymal Stem Cells Induces CD4+FOXP3+ Cells and Increases IL-10 Secretion

(2012) Ekaterina Ivanova-Todorova et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources

(2010) Mehdi Najar et al.   CELLULAR IMMUNOLOGY

Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism

(2010) Ke Chen et al.   CLINICAL IMMUNOLOGY

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

(2010) Martin J Hoogduijn et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression

(2010) Guangwen Ren et al.   JOURNAL OF IMMUNOLOGY

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues

(2009) Keon Hee Yoo et al.   CELLULAR IMMUNOLOGY

Cell contact, prostaglandin E2and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+regulatory T cells

(2009) K. English et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Optimizing mesenchymal stem cell-based therapeutics

(2009) Joseph Wagner et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6

(2009) Mehdi Najar et al.   CYTOTHERAPY

Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10

(2009) Seung-Ha Yang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Requirement of IFN-γ–Mediated Indoleamine 2,3-Dioxygenase Expression in the Modulation of Lymphocyte Proliferation by Human Adipose–Derived Stem Cells

(2009) Olga DelaRosa et al.   TISSUE ENGINEERING PART A

A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1

(2008) Huiming Sheng et al.   CELL RESEARCH

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function

(2008) Rajesh Ramasamy et al.   CELLULAR IMMUNOLOGY

IFN-γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease

(2008) David Polchert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells

(2008) Mark L. Weiss et al.   STEM CELLS

Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche

(2007) Lizzia Raffaghello et al.   STEM CELLS