Nanomedicine for Infectious Disease Applications: Innovation towards Broad-Spectrum Treatment of Viral Infections

Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses

(2015) Gabriel L. Hendricks et al.   ANTIVIRAL RESEARCH

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome

(2015) Nam-Joon Cho et al.   GASTROENTEROLOGY

Size Dependence of Steric Shielding and Multivalency Effects for Globular Binding Inhibitors

(2015) Jonathan Vonnemann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

(2015) Joshua A. Jackman et al.   Small

Nanomedicines: addressing the scientific and regulatory gap

(2014) Sally Tinkle et al.   Annals of the New York Academy of Sciences

Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors

(2014) Axel Hollmann et al.   BIOCHEMICAL JOURNAL

Nanomedicine in the management of microbial infection – Overview and perspectives

(2014) Xi Zhu et al.   Nano Today

Tannic Acid Modified Silver Nanoparticles Show Antiviral Activity in Herpes Simplex Virus Type 2 Infection

(2014) Piotr Orlowski et al.   PLoS One

Emerging Viral Diseases: Confronting Threats with New Technologies

(2014) H. D. Marston et al.   Science Translational Medicine

Virus Capture and Destruction by Label-Free Graphene Oxide for Detection and Disinfection Applications

(2014) Zhiyong Song et al.   Small

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

(2013) Jinjin Zhang et al.   BIOMATERIALS

Sialylneolacto-N-tetraose c (LSTc)-bearing Liposomal Decoys Capture Influenza A Virus

(2013) Gabriel L. Hendricks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rupture of Lipid Vesicles by a Broad-Spectrum Antiviral Peptide: Influence of Vesicle Size

(2013) Joshua A. Jackman et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Rigid Amphipathic Fusion Inhibitor dUY11 Acts through Photosensitization of Viruses

(2013) F. Vigant et al.   JOURNAL OF VIROLOGY

5-(Perylen-3-yl)Ethynyl-arabino-Uridine (aUY11), an Arabino-Based Rigid Amphipathic Fusion Inhibitor, Targets Virion Envelope Lipids To Inhibit Fusion of Influenza Virus, Hepatitis C Virus, and Other Enveloped Viruses

(2013) C. C. Colpitts et al.   JOURNAL OF VIROLOGY

Virus inhibition induced by polyvalent nanoparticles of different sizes

(2013) Jonathan Vonnemann et al.   Nanoscale

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

(2013) Frederic Vigant et al.   PLoS Pathogens

Sublimable C5A Delivery Provides Sustained and Prolonged Anti-HIV Microbicidal Activities

(2012) Richard Maskiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Liposome-Mediated Delivery of Iminosugars Enhances Efficacy against Dengue VirusIn Vivo

(2012) Joanna L. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Single Vesicle Analysis Reveals Nanoscale Membrane Curvature Selective Pore Formation in Lipid Membranes by an Antiviral α-Helical Peptide

(2012) Seyed R. Tabaei et al.   NANO LETTERS

The big picture on nanomedicine: the state of investigational and approved nanomedicine products

(2012) Michael L. Etheridge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Sustained Local Delivery of Structurally Diverse HIV-1 Microbicides Released from Sublimation Enthalpy Controlled Matrices

(2012) Simi Gunaseelan et al.   PHARMACEUTICAL RESEARCH

Self-Assembling Peptide Nanotubes with Antiviral Activity against Hepatitis C Virus

(2011) Ana Montero et al.   CHEMISTRY & BIOLOGY

Development of a liposome microbicide formulation for vaginal delivery of octylglycerol for HIV prevention

(2011) Lin Wang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Silver Nanoparticles as Potential Antiviral Agents

(2011) Stefania Galdiero et al.   MOLECULES

HSV Neutralization by the Microbicidal Candidate C5A

(2011) Lot de Witte et al.   PLoS One

Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds

(2011) Humberto H Lara et al.   JOURNAL OF NANOBIOTECHNOLOGY

Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

(2010) Sze Yinn Wong et al.   BIOMATERIALS

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells

(2010) S. Pollock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A broad-spectrum antiviral targeting entry of enveloped viruses

(2010) M. C. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses

(2010) M. R. St.Vincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Driving a wedge between viral lipids blocks infection

(2010) G. B. Melikyan   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Influenza Virus Infection by Multivalent Sialic-Acid-Functionalized Gold Nanoparticles

(2010) Ilona Papp et al.   Small

Inhibition of HSV-1 Attachment, Entry, and Cell-to-Cell Spread by Functionalized Multivalent Gold Nanoparticles

(2010) Dana Baram-Pinto et al.   Small

Mode of antiviral action of silver nanoparticles against HIV-1

(2010) Humberto H Lara et al.   JOURNAL OF NANOBIOTECHNOLOGY

Mechanism of an Amphipathic α-Helical Peptide’s Antiviral Activity Involves Size-Dependent Virus Particle Lysis

(2009) Nam-Joon Cho et al.   ACS Chemical Biology

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery

(2008) Stephanie Pollock et al.   AIDS

Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

(2008) Mary-Catherine Bowman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY

Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus

(2008) M. D. Bobardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A virocidal amphipathic  -helical peptide that inhibits hepatitis C virus infection in vitro

(2008) G. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA