The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer’s Disease Therapeutics and Diagnostics

Nanoparticle crossing of blood–brain barrier: a road to new therapeutic approaches to central nervous system diseases

(2018) Valentín Ceña et al.   Nanomedicine

Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model

(2018) Dario Carradori et al.   Nanomedicine-Nanotechnology Biology and Medicine

The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle

(2018) Dao-zhou Liu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

SPION-Enhanced Magnetic Resonance Imaging of Alzheimer's Disease Plaques in AβPP/PS-1 Transgenic Mouse Brain

(2018) Laurel O. Sillerud et al.   JOURNAL OF ALZHEIMERS DISEASE

Biomimetics in drug delivery systems: A critical review

(2017) Mojgan Sheikhpour et al.   JOURNAL OF CONTROLLED RELEASE

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

(2017) Ming Ming Wen et al.   JOURNAL OF CONTROLLED RELEASE

Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

(2017) Joana Loureiro et al.   MOLECULES

Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer's Aβ peptide

(2017) Maria Gregori et al.   Nanomedicine-Nanotechnology Biology and Medicine

Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders

(2017) Alisa E. Shaw et al.   PHARMACOLOGY & THERAPEUTICS

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Use of PEGylated Immunoliposomes to Deliver Dopamine Across the Blood-Brain Barrier in a Rat Model of Parkinson's Disease

(2016) Young-Sook Kang et al.   CNS Neuroscience & Therapeutics

Glial Cells - The Key Elements of Alzheimers Disease

(2016) David Dzamba et al.   Current Alzheimer Research

Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems

(2016) S. Cunha et al.   CURRENT MEDICINAL CHEMISTRY

Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease

(2016) Eameema Muntimadugu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

(2016) Débora Vieira et al.   International Journal of Nanomedicine

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs

(2016) Carlo Cervellati et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease

(2016) Simona Mancini et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanostructured lipid carriers: Promising drug delivery systems for future clinics

(2016) Ana Beloqui et al.   Nanomedicine-Nanotechnology Biology and Medicine

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

(2016) Tal Iram et al.   NEUROBIOLOGY OF DISEASE

Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease

(2016) Aishwarya Vedagiri et al.   NEUROPEPTIDES

Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting

(2016) Marie Plissonneau et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

(2015) Bingbing Hu et al.   ADVANCED MATERIALS

Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

(2015) Kwok Kin Cheng et al.   BIOMATERIALS

A sensitive colorimetric strategy for monitoring cerebral β-amyloid peptides in AD based on dual-functionalized gold nanoplasmonic particles

(2015) Yan-yan Yu et al.   CHEMICAL COMMUNICATIONS

A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

(2015) Fanfei Meng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dual ligand immunoliposomes for drug delivery to the brain

(2015) Joana A. Loureiro et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Ins and Outs of Nanoparticle Technology in Neurodegenerative Diseases and Cancer

(2015) Cornelia Wilson et al.   CURRENT DRUG METABOLISM

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

(2015) Charles Finsterwald et al.   CURRENT PHARMACEUTICAL DESIGN

Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization,in vitroandin vivoevaluations

(2015) Shubham Misra et al.   DRUG DELIVERY

Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain

(2015) Amira S. Hanafy et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Therapeutic approaches of magnetic nanoparticles for the central nervous system

(2015) Fahima Dilnawaz et al.   DRUG DISCOVERY TODAY

Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches

(2015) Marcelo Kogan et al.   International Journal of Nanomedicine

Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice

(2015) Lara Ordóñez-Gutiérrez et al.   Nanomedicine-Nanotechnology Biology and Medicine

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations

(2015) Catherine Chiu et al.   NEUROBIOLOGY OF AGING

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

(2015) J A Woo et al.   Cell Death & Disease

Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)

(2015) Hagit Sela et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

(2015) Laura J Blair et al.   Acta Neuropathologica Communications

Multifunctional nanoliposomes with curcumin–lipid derivative and brain targeting functionality with potential applications for Alzheimer disease

(2014) Spyridon Mourtas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits

(2014) Edward K. Agyare et al.   JOURNAL OF CONTROLLED RELEASE

Aβ Influences Cytoskeletal Signaling Cascades with Consequences to Alzheimer’s Disease

(2014) Ana Gabriela Henriques et al.   MOLECULAR NEUROBIOLOGY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

(2014) Xue Xue et al.   NANO LETTERS

Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

(2014) Kirsten L. Viola et al.   Nature Nanotechnology

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Animal models of Alzheimer disease: historical pitfalls and a path forward

(2014) Sarah E. Cavanaugh   ALTEX-Alternatives to Animal Experimentation

Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti-Intracranial Infection Applications

(2014) Kun Shao et al.   Advanced Healthcare Materials

Stable Conjugates of Peptides with Gold Nanorods for Biomedical Applications with Reduced Effects on Cell Viability

(2013) Carolina Adura et al.   ACS Applied Materials & Interfaces

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

(2013) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

Effect of Poly(propylene imine) Glycodendrimers on β-Amyloid Aggregation in Vitro and in APP/PS1 Transgenic Mice, as a Model of Brain Amyloid Deposition and Alzheimer’s Disease

(2013) O. Klementieva et al.   BIOMACROMOLECULES

Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice

(2013) Chi Zhang et al.   BIOMATERIALS

A carbon nanotube metal semiconductor field effect transistor-based biosensor for detection of amyloid-beta in human serum

(2013) Jeseung Oh et al.   BIOSENSORS & BIOELECTRONICS

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes

(2013) Boyi Qu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway

(2013) Seung-Eon Roh et al.   FASEB JOURNAL

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils

(2013) Shlomo Margel et al.   International Journal of Nanomedicine

Enhanced brain distribution and pharmacodynamics of rivastigmine by liposomes following intranasal administration

(2013) Zhen-Zhen Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide

(2013) Wenxia Li et al.   Molecular Neurodegeneration

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Molecular mechanisms of dendrite stability

(2013) Anthony J. Koleske   NATURE REVIEWS NEUROSCIENCE

Ligand-targeted liposome design: challenges and fundamental considerations

(2013) Gavin T. Noble et al.   TRENDS IN BIOTECHNOLOGY

Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration

(2012) J A Woo et al.   CELL DEATH AND DIFFERENTIATION

Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes

(2012) Weize Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

(2012) Mohammad Fazil et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Functionalized carbon nanotubes: biomedical applications

(2012) Shree Singh et al.   International Journal of Nanomedicine

Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer’s disease models

(2012) Andressa Bernardi et al.   International Journal of Nanomedicine

Preparation, characterization,in vivoand biochemical evaluation of brain targeted Piperine solid lipid nanoparticles in an experimentally induced Alzheimer’s disease model

(2012) Mohammad Yusuf et al.   JOURNAL OF DRUG TARGETING

Dendrimers reduce toxicity of Aβ 1-28 peptide during aggregation and accelerate fibril formation

(2012) Barbara Klajnert et al.   Nanomedicine-Nanotechnology Biology and Medicine

A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic β-Amyloid Oligomers

(2012) Lívia Fülöp et al.   PLoS One

Negatively Charged Gold Nanoparticles Inhibit Alzheimer's Amyloid-β Fibrillization, Induce Fibril Dissociation, and Mitigate Neurotoxicity

(2012) Yi-Hung Liao et al.   Small

Carbon Nanotube Inhibits the Formation of β-Sheet-Rich Oligomers of the Alzheimer's Amyloid-β(16-22) Peptide

(2011) Huiyu Li et al.   BIOPHYSICAL JOURNAL

Dendrimer-mediated siRNA delivery knocks down Beclin 1 and potentiates NMDA-mediated toxicity in rat cortical neurons

(2011) María D. Pérez-Carrión et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorus Dendrimers Affect Alzheimer’s (Aβ1–28) Peptide and MAP-Tau Protein Aggregation

(2011) Tomasz Wasiak et al.   MOLECULAR PHARMACEUTICS

Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System

(2011) Francisco C. Pérez-Martínez et al.   PHARMACEUTICAL RESEARCH

Roles of NG2 glial cells in diseases of the central nervous system

(2011) Jian-Ping Xu et al.   Neuroscience Bulletin

Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease

(2010) Zhong Yang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Multifunctional magnetic nanoparticles for medical imaging applications

(2009) Chen Fang et al.   JOURNAL OF MATERIALS CHEMISTRY

Interruption of  -Catenin Signaling Reduces Neurogenesis in Alzheimer's Disease

(2009) P. He et al.   JOURNAL OF NEUROSCIENCE

Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine

(2009) Barnabas Wilson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON