Soluble NKG2D ligands limit the efficacy of immune checkpoint blockade

DNA Damage in Stem Cells

(2017) Ilio Vitale et al.   MOLECULAR CELL

Soluble NKG2D ligands are biomarkers associated with the clinical outcome to immune checkpoint blockade therapy of metastatic melanoma patients

(2017) Cristina Maccalli et al.   OncoImmunology

Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy

(2017) Jingyu Zhang et al.   Science Advances

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

(2015) W. Deng et al.   SCIENCE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Antibody targeting soluble NKG2D ligand sMIC refuels and invigorates the endogenous immune system to fight cancer

(2015) Jennifer Wu   OncoImmunology

Drug-induced hyperploidy stimulates an antitumor NK cell response mediated by NKG2D and DNAM-1 receptors

(2015) Andrea Acebes-Huerta et al.   OncoImmunology

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications

(2015) Aitziber Buqué et al.   OncoImmunology

Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?

(2015) Guido Kroemer et al.   OncoImmunology

Immunological markers and clinical outcome of advanced melanoma patients receiving ipilimumab plus fotemustine in the NIBIT-M1 study

(2015) Cristina Maccalli et al.   OncoImmunology

ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing

(2015) Maria Raffaella Zocchi et al.   OncoImmunology

NKG2D signaling in cancer immunosurveillance

(2014) Alejandro López-Soto et al.   INTERNATIONAL JOURNAL OF CANCER