Trial Watch: Immunotherapy plus radiation therapy for oncological indications

Trabectedin for Soft Tissue Sarcoma: Current Status and Future Perspectives

(2016) Erlinda M. Gordon et al.   ADVANCES IN THERAPY

Trabectedin for the treatment of soft tissue sarcomas

(2016) Rita De Sanctis et al.   EXPERT OPINION ON PHARMACOTHERAPY

FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4

(2016) Qiang Zhang et al.   MOLECULAR CELL

Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?

(2016) Michael B. Bernstein et al.   Nature Reviews Clinical Oncology

Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts

(2016) Giuseppina Comito et al.   Oncotarget

Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy

(2016) Aitziber Buqué et al.   OncoImmunology

Immunological Characterization of Whole Tumour Lysate-Loaded Dendritic Cells for Cancer Immunotherapy

(2016) Veronica Rainone et al.   PLoS One

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors

(2015) Anja Derer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Abscopal effects of radiation therapy: A clinical review for the radiobiologist

(2015) Shankar Siva et al.   CANCER LETTERS

Abstract 2493: Fractionated but not single dose radiation is an optimal adjuvant for in situ tumor vaccination

(2015) Claire Isabelle Vanpouille-Box et al.   CANCER RESEARCH

Abstract 244: Abscopal responses in patients with refractory metastatic NSCLC treated with concurrent radiotherapy and CTLA-4 immune checkpoint blockade: evidence for the in situ vaccination hypothesis of radiotherapy:

(2015) Encouse B. Golden et al.   CANCER RESEARCH

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Historical review on thymosin α1 in oncology: preclinical and clinical experiences

(2015) Enrico Garaci et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

(2015) L. Ruggeri et al.   HAEMATOLOGICA

Complement Is a Central Mediator of Radiotherapy-Induced Tumor-Specific Immunity and Clinical Response

(2015) Laura Surace et al.   IMMUNITY

NKG2A expression and impaired function of NK cells in patients with new onset of Graves' disease

(2015) Yupan Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Perioperative treatment with the new synthetic TLR-4 agonist GLA-SE reduces cancer metastasis without adverse effects

(2015) Pini Matzner et al.   INTERNATIONAL JOURNAL OF CANCER

Zoledronic acid enhances antitumor efficacy of liposomal doxorubicin

(2015) YOSHIYUKI HATTORI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Myelodysplastic Syndrome Successfully Treated With Adalimumab

(2015) Anca Prica et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

(2015) Kevin C. Soares et al.   JOURNAL OF IMMUNOTHERAPY

Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: a randomised, open-label, phase 2 study

(2015) Akira Kawai et al.   LANCET ONCOLOGY

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial

(2015) Encouse B Golden et al.   LANCET ONCOLOGY

Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy

(2015) Andrew B Sharabi et al.   LANCET ONCOLOGY

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study

(2015) Tony Reid et al.   LANCET ONCOLOGY

Radiation in combination with immune-checkpoint inhibitors

(2015) Susan Mayor   LANCET ONCOLOGY

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer

(2015) M. Mondini et al.   MOLECULAR CANCER THERAPEUTICS

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

(2015) Stephen M. Ansell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune checkpoint modulation: Rational design of combination strategies

(2015) Dmitriy Zamarin et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy

(2015) Everett J. Moding et al.   Science Translational Medicine

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair

(2015) Firas L. Tarish et al.   Science Translational Medicine

PD-L1 Blockade for Cancer Treatment: MEDI4736

(2015) Ramy Ibrahim et al.   SEMINARS IN ONCOLOGY

Current Perspectives in Immunotherapy for Non-Small Cell Lung Cancer

(2015) Edward B. Garon   SEMINARS IN ONCOLOGY

Current Clinical Trials Testing Combinations of Immunotherapy and Radiation

(2015) Marka Crittenden et al.   SEMINARS IN RADIATION ONCOLOGY

Radiation and Inflammation

(2015) Dörthe Schaue et al.   SEMINARS IN RADIATION ONCOLOGY

In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment

(2015) Claire Vanpouille-Box et al.   VACCINE

More Benefits for Checkpoint Inhibitors in NSCLC

(2015)   Cancer Discovery

PD-1 pathway inhibitors: The next generation of immunotherapy for advanced melanoma

(2015) Jason J. Luke et al.   Oncotarget

Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation

(2015) Andreyan N. Osipov et al.   Oncotarget

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

(2015) Jason M. Beckta et al.   Oncotarget

Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

(2015) Xiao-Hua Jia et al.   Oncotarget

Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells

(2015) So-Yeon Park et al.   Oncotarget

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells

(2015) Dayson Moreira et al.   Oncotarget

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo

(2015) Frank P. Vendetti et al.   Oncotarget

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

(2015) L. Ruggeri et al.   HAEMATOLOGICA

Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells

(2015) B. Boyerinas et al.   Cancer Immunology Research

The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophagesin situ

(2015) Sayantan Banerjee et al.   OncoImmunology

Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma

(2015) Melanie Ruf et al.   OncoImmunology

“In situ” vaccination for systemic effects in follicular lymphoma

(2015) Arne Kolstad et al.   OncoImmunology

Trial Watch: Adoptive cell transfer for oncological indications

(2015) Fernando Aranda et al.   OncoImmunology

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

(2015) Kanae Yumimoto et al.   OncoImmunology

Immunotherapy of hematological cancers: PD-1 blockade for the treatment of Hodgkin's lymphoma

(2015) Guido Kroemer et al.   OncoImmunology

Tumor infiltrating CD8+T lymphocyte count is independent of tumor TLR9 status in treatment naïve triple negative breast cancer and renal cell carcinoma

(2015) Mikko Mella et al.   OncoImmunology

Indoleamine 2,3-dioxygenase vaccination

(2015) Mads Hald Andersen et al.   OncoImmunology

Trial watch: Tumor-targeting monoclonal antibodies for oncological indications

(2015) Erika Vacchelli et al.   OncoImmunology

Trial Watch: Peptide-based anticancer vaccines

(2015) Jonathan Pol et al.   OncoImmunology

Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients

(2015) Kalijn F Bol et al.   OncoImmunology

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications

(2015) Aitziber Buqué et al.   OncoImmunology

Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma—An exclamation sign with a question mark

(2015) Guido Kroemer et al.   OncoImmunology

An optimized peptide vaccine strategy capable of inducing multivalent CD8+T cell responses with potent antitumor effects

(2015) Hyun-Il Cho et al.   OncoImmunology

The antitumor immune response generated by fractionated radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade

(2015) S J Dovedi et al.   OncoImmunology

COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells

(2015) Ze-Lei Li et al.   OncoImmunology

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells

(2015) Annie A Wu et al.   OncoImmunology

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab

(2015) Venky Ramakrishna et al.   Journal for ImmunoTherapy of Cancer

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma

(2015) Iris Chiara Salaroglio et al.   Oncotarget

Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions

(2015) Kazuko Sakai et al.   Oncotarget

Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation

(2015) Eng-Yen Huang et al.   Oncotarget

Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity

(2015) Vinod Pant et al.   Oncotarget

FAK Inhibition with Small Molecule Inhibitor Y15 Decreases Viability, Clonogenicity, and Cell Attachment in Thyroid Cancer Cell Lines and Synergizes with Targeted Therapeutics

(2015) Shalana O’Brien et al.   Oncotarget

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

(2015) Shu-biao Ye et al.   Oncotarget

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

Aberrant regulation of FBW7 in cancer

(2015) Lixia Wang et al.   Oncotarget

Regulation of p53 by Mdm2 E3 Ligase Function Is Dispensable in Embryogenesis and Development, but Essential in Response to DNA Damage

(2014) Laura A. Tollini et al.   CANCER CELL

An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial–mesenchymal transition

(2014) Chul-Yong Park et al.   CANCER LETTERS

Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules

(2014) Kevin Leder et al.   CELL

SnapShot: Cancer Vaccines

(2014) Karolina Palucka et al.   CELL

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer

(2014) M.-G. Anitei et al.   CLINICAL CANCER RESEARCH

Impact of myeloid cells on the efficacy of anticancer chemotherapy

(2014) Laura Senovilla et al.   CURRENT OPINION IN IMMUNOLOGY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma

(2014) Robert L Bowman et al.   Immunotherapy

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Imiquimod in the Treatment of Breast Cancer Skin Metastasis

(2014) Lisa Henriques et al.   JOURNAL OF CLINICAL ONCOLOGY

New Approaches Tackle Rising Pancreatic Cancer Rates

(2014) V. Brower   JNCI-Journal of the National Cancer Institute

Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients

(2014) Hisae Iinuma et al.   Journal of Translational Medicine

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

(2014) Caroline Robert et al.   LANCET

Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): an open-label, randomised, phase 3 factorial trial

(2014) James W Denham et al.   LANCET ONCOLOGY

Enzalutamide monotherapy in hormone-naive prostate cancer: primary analysis of an open-label, single-arm, phase 2 study

(2014) Bertrand Tombal et al.   LANCET ONCOLOGY

Novel oncolytic adenovirus sensitizes renal cell carcinoma cells to radiotherapy via mitochondrial apoptotic cell death

(2014) REN-FU CHEN et al.   Molecular Medicine Reports

A Phase 1 Trial of Oncolytic HSV-1, G207, Given in Combination With Radiation for Recurrent GBM Demonstrates Safety and Radiographic Responses

(2014) James M Markert et al.   MOLECULAR THERAPY

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Organelle-specific initiation of cell death

(2014) Lorenzo Galluzzi et al.   NATURE CELL BIOLOGY

The development of immunoconjugates for targeted cancer therapy

(2014) Brandon G. Smaglo et al.   Nature Reviews Clinical Oncology

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

The Optimal Partnership of Radiation and Immunotherapy: from Preclinical Studies to Clinical Translation

(2014) Sandra Demaria et al.   RADIATION RESEARCH

Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway

(2014) P. Vantourout et al.   Science Translational Medicine

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Cytotoxic effect of a combination of bluetongue virus and radiation on prostate cancer

(2014) WEI WANG et al.   Experimental and Therapeutic Medicine

Trial Watch

(2014) Jonathan Pol et al.   OncoImmunology

Immunosurveillance of senescent cancer cells by natural killer cells

(2014) Alexandre Iannello et al.   OncoImmunology

Push and release

(2014) Marcin Kortylewski et al.   OncoImmunology

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide

(2014) Xin Chen et al.   OncoImmunology

Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression

(2014) liufu deng et al.   OncoImmunology

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Targeting tumor-associated macrophages in cancer therapy and understanding their complexity

(2014) Michael A. Cannarile et al.   OncoImmunology

Tumor immune remodeling by TGFβ inhibition improves the efficacy of radiation therapy

(2014) Kristina H Young et al.   OncoImmunology

Trial Watch: Radioimmunotherapy for oncological indications

(2014) Norma Bloy et al.   OncoImmunology

Immune checkpoint blockade in malignant mesothelioma

(2014) Luana Calabrò et al.   OncoImmunology

Immune checkpoints

(2014) Akhil Chawla et al.   OncoImmunology

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Dual targeting of CD137 co-stimulatory and PD-1 co-inhibitory molecules for ovarian cancer immunotherapy

(2014) Huafeng Wei et al.   OncoImmunology

Trial watch

(2014) Erika Vacchelli et al.   OncoImmunology

Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity

(2014) Lawrence J Thomas et al.   OncoImmunology

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Is tumor (R)ejection by the immune system the “5th R” of radiobiology?

(2014) Encouse Golden et al.   OncoImmunology

Trial watch: IDO inhibitors in cancer therapy

(2014) Erika Vacchelli et al.   OncoImmunology

Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes

(2014) Lidia Robert et al.   OncoImmunology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Trial Watch:

(2014) Jonathan Pol et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Combinations of Immunotherapy and Radiation in Cancer Therapy

(2014) Ralph E. Vatner et al.   Frontiers in Oncology

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

(2013) Mark T. Orr et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

(2013) Laurence Zitvogel et al.   IMMUNITY

Combination of fractionated irradiation with anti-VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium

(2013) Lisa Buckel et al.   INTERNATIONAL JOURNAL OF CANCER

Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses

(2013) L. Huang et al.   JOURNAL OF IMMUNOLOGY

Agonist Anti-Human CD27 Monoclonal Antibody Induces T Cell Activation and Tumor Immunity in Human CD27-Transgenic Mice

(2013) L.-Z. He et al.   JOURNAL OF IMMUNOLOGY

Effects of Tumor Irradiation on Host T-Regulatory Cells and Systemic Immunity in the Context of Adoptive T-Cell Therapy in Mice

(2013) Shuang Wei et al.   JOURNAL OF IMMUNOTHERAPY

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

(2013) Jérôme Galon et al.   JOURNAL OF PATHOLOGY

Combining Radiotherapy and Cancer Immunotherapy: A Paradigm Shift

(2013) Silvia C. Formenti et al.   JNCI-Journal of the National Cancer Institute

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in V600D/EBRAF mutant melanoma depends on JNK and TNF-α signaling

(2013) J N Kyula et al.   ONCOGENE

Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

(2013) Chiara Riganti et al.   PLoS One

An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non-Small Cell Lung Cancer

(2013) E. B. Golden et al.   Cancer Immunology Research

Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment

(2013) Sandra Demaria et al.   OncoImmunology

Trial Watch

(2013) Erika Vacchelli et al.   OncoImmunology

The TLR7 agonist imiquimod as an adjuvant for radiotherapy-elicited in situ vaccination against breast cancer

(2013) Sandra Demaria et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma

(2012) S. J. Dovedi et al.   BLOOD

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer

(2012) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Radiation Therapy to Convert the Tumor Into an In Situ Vaccine

(2012) Silvia C. Formenti et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Suppressing T cell motility induced by anti–CTLA-4 monotherapy improves antitumor effects

(2012) Maria Grazia Ruocco et al.   JOURNAL OF CLINICAL INVESTIGATION

Dacarbazine-Mediated Upregulation of NKG2D Ligands on Tumor Cells Activates NK and CD8 T Cells and Restrains Melanoma Growth

(2012) Alice Hervieu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Second Malignant Neoplasms and Cardiovascular Disease Following Radiotherapy

(2012) Lois B. Travis et al.   JNCI-Journal of the National Cancer Institute

Past, present and future of radiotherapy for the benefit of patients

(2012) Juliette Thariat et al.   Nature Reviews Clinical Oncology

Abscopal Effect in a Patient with Melanoma

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2--Tumor and Immunological Responses

(2012) S. K. Seung et al.   Science Translational Medicine

Advances in radiotherapy

(2012) S. S. Ahmad et al.   BMJ-British Medical Journal

Trial watch

(2012) Laura Senovilla et al.   OncoImmunology

The convergence of radiation and immunogenic cell death signaling pathways

(2012) Encouse B. Golden et al.   Frontiers in Oncology

Radiation as an immunological adjuvant: current evidence on dose and fractionation

(2012) Sandra Demaria et al.   Frontiers in Oncology

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer

(2011) Koji Yasuda et al.   CANCER SCIENCE

TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

(2011) F. Bouquet et al.   CLINICAL CANCER RESEARCH

Treatment of Locally Recurrent Mucosal Melanoma With Topical Imiquimod

(2011) Elizabeth C. Smyth et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

(2011) Howard Trachtman et al.   KIDNEY INTERNATIONAL

Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries

(2011) Amy Berrington de Gonzalez et al.   LANCET ONCOLOGY

Clinical radioimmunotherapy—the role of radiobiology

(2011) Jean-Pierre Pouget et al.   Nature Reviews Clinical Oncology

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Targeting human dendritic cell subsets for improved vaccines

(2011) Hideki Ueno et al.   SEMINARS IN IMMUNOLOGY

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Decreasing the Adverse Effects of Cancer Therapy: National Cancer Institute Guidance for the Clinical Development of Radiation Injury Mitigators

(2010) B. Movsas et al.   CLINICAL CANCER RESEARCH

Use of Normal Tissue Complication Probability Models in the Clinic

(2010) Lawrence B. Marks et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The expanding family of dendritic cell subsets

(2010) Hideki Ueno et al.   NATURE BIOTECHNOLOGY

Radiotherapy Enhances Antitumor Effect of Anti-CD137 Therapy in a Mouse Glioma Model

(2010) Elizabeth W. Newcomb et al.   RADIATION RESEARCH

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review

(2009) Maurice Tubiana   RADIOTHERAPY AND ONCOLOGY

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells

(2008) Nathalie T. Joncker et al.   IMMUNOLOGICAL REVIEWS

American Society of Clinical Oncology 2008 Clinical Practice Guideline Update: Use of Chemotherapy and Radiation Therapy Protectants

(2008) Martee L. Hensley et al.   JOURNAL OF CLINICAL ONCOLOGY

Treatment of Vulvar Intraepithelial Neoplasia with Topical Imiquimod

(2008) Manon van Seters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE