Emerging Role of Immunosuppression in Diseases Induced by Micro- and Nano-Particles: Time to Revisit the Exclusive Inflammatory Scenario

Regulatory T cells: a potential target in cancer immunotherapy

(2018) Kohei Shitara et al.   Annals of the New York Academy of Sciences

Plasticity of myeloid-derived suppressor cells in cancer

(2018) Evgenii Tcyganov et al.   CURRENT OPINION IN IMMUNOLOGY

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

(2018) Shetal A. Patel et al.   IMMUNITY

Comparative RNA-Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis model

(2018) Jiayi Chen et al.   JOURNAL OF APPLIED TOXICOLOGY

Liposome-induced immunosuppression and tumor growth is mediated by macrophages and mitigated by liposome-encapsulated alendronate

(2018) Robin Rajan et al.   JOURNAL OF CONTROLLED RELEASE

Inflammasome-Independent Leukotriene B4Production Drives Crystalline Silica–Induced Sterile Inflammation

(2018) Bindu Hegde et al.   JOURNAL OF IMMUNOLOGY

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis

(2018) Jie Dong et al.   Nanotoxicology

Macrophage polarization and allergic asthma

(2018) Arjun Saradna et al.   Translational Research

Modulating inflammation in a cutaneous chronic wound model by IL-10 released from collagen–silica nanocomposites via gene delivery

(2018) Xiaolin Wang et al.   Biomaterials Science

Macrophage Recognition of Crystals and Nanoparticles

(2018) Masafumi Nakayama   Frontiers in Immunology

Tumor-Associated Macrophages: Therapeutic Targets for Skin Cancer

(2018) Taku Fujimura et al.   Frontiers in Oncology

Interleukin-10–mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling

(2017) Swathi Balaji et al.   FASEB JOURNAL

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration

(2017) Fern Findlay et al.   JOURNAL OF IMMUNOLOGY

CCR2+ monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-β1

(2017) Astrid Lebrun et al.   JOURNAL OF PATHOLOGY

Effects of Occupational Silica Exposure on OXIDATIVE Stress and Immune System Parameters in Ceramic Workers in TURKEY

(2017) Hatice Gul Anlar et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro

(2017) Yiping Lu et al.   MEDIATORS OF INFLAMMATION

Occupational lung diseases in Australia

(2017) Ryan F Hoy et al.   MEDICAL JOURNAL OF AUSTRALIA

Artificial stone-associated silicosis: a rapidly emerging occupational lung disease

(2017) Ryan F Hoy et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica

(2017) Hans Christian Winkler et al.   Particle and Fibre Toxicology

Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation

(2017) Jie Dong et al.   Particle and Fibre Toxicology

Imipramine blocks acute silicosis in a mouse model

(2017) Rupa Biswas et al.   Particle and Fibre Toxicology

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

(2017) Julie Stockis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticles and innate immunity: new perspectives on host defence

(2017) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Role of epithelial-mesenchymal transition (EMT) and fibroblast function in cerium oxide nanoparticles-induced lung fibrosis

(2017) Jane Ma et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Follistatin like-1 aggravates silica-induced mouse lung injury

(2017) Yinshan Fang et al.   Scientific Reports

Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos

(2017) Hidenori Matsuzaki et al.   Environmental Health and Preventive Medicine

Synthetic Nanoparticles That Promote Tumor Necrosis Factor Receptor 2 Expressing Regulatory T Cells in the Lung and Resistance to Allergic Airways Inflammation

(2017) Rohimah Mohamud et al.   Frontiers in Immunology

IL-10-Producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients

(2017) Ying Chen et al.   Frontiers in Immunology

Extended Tumor Control after Dendritic Cell Vaccination with Low-Dose Cyclophosphamide as Adjuvant Treatment in Patients with Malignant Pleural Mesothelioma

(2016) Robin Cornelissen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Macrophage (M1 and M2) in Titanium-Dioxide Nanoparticle-Induced Oxidative Stress and Inflammatory Response in Rat

(2016) Sumit Kumar et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Inflammation-Related IL1 /IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma

(2016) Y. Kadariya et al.   Cancer Prevention Research

Denim production and silicosis

(2016) Metin Akgün   CURRENT OPINION IN PULMONARY MEDICINE

Nanoparticles and direct immunosuppression

(2016) Terrika A Ngobili et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Dynamic changes of mononuclear phagocytes in circulating, pulmonary alveolar and interstitial compartments in a mouse model of experimental silicosis

(2016) Guo-An Xiang et al.   INHALATION TOXICOLOGY

Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages

(2016) Anne-Laure Chéné et al.   Journal of Thoracic Oncology

Blockade of Wnt/β-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses

(2016) Wujing Dai et al.   MEDIATORS OF INFLAMMATION

Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms

(2016) Lingling Ou et al.   Particle and Fibre Toxicology

Proteomic profiling change during the early development of silicosis disease

(2016) Rongming Miao et al.   Journal of Thoracic Disease

Silica, Silicosis, and Autoimmunity

(2016) Kenneth Michael Pollard   Frontiers in Immunology

Murine mesothelioma induces locally-proliferating IL-10+TNF-α+CD206−CX3CR1+ M3 macrophages that can be selectively depleted by chemotherapy or immunotherapy

(2016) Connie Jackaman et al.   OncoImmunology

Association of Transforming Growth Factor β1 Gene Polymorphisms and Asbestos-Induced Fibrosis and Tumors

(2016) Simone Helmig et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis

(2016) Fangwei Liu et al.   Scientific Reports

Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

(2015) Anurag Mishra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Pneumocyte–Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis

(2015) Freddy Romero et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MDSC and TGF  Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes

(2015) A. A. Shvedova et al.   CANCER RESEARCH

Blocking TGF-β expression inhibits silica particle-induced epithelial–mesenchymal transition in human lung epithelial cells

(2015) Yi Rong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure

(2015) Shubha Murthy et al.   FASEB JOURNAL

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

IL-1α induces CD11blowalveolar macrophage proliferation and maturation during granuloma formation

(2015) François Huaux et al.   JOURNAL OF PATHOLOGY

Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway

(2015) Manuela Polimeni et al.   Particle and Fibre Toxicology

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

(2015) Giulia Vietti et al.   Particle and Fibre Toxicology

Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

(2015) Dalibor Breznan et al.   Particle and Fibre Toxicology

The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases

(2015) Mutlay Sayan et al.   Particle and Fibre Toxicology

The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles

(2015) Virginie Rabolli et al.   Particle and Fibre Toxicology

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor

(2015) Elina M. Rydman et al.   TOXICOLOGICAL SCIENCES

Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos

(2015) Chen Ying et al.   TOXICOLOGY

Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth

(2015) Shuchismita R. Satpathy et al.   Nature Communications

Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells

(2015) Chitra Thakur et al.   Oncotarget

Blocking the Wnt/β-Catenin Pathway by Lentivirus-Mediated Short Hairpin RNA Targeting β-Catenin Gene Suppresses Silica-Induced Lung Fibrosis in Mice

(2015) Xin Wang et al.   International Journal of Environmental Research and Public Health

Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse

(2015) Melissa A. Bates et al.   PLoS One

Silica-induced Chronic Inflammation Promotes Lung Carcinogenesis in the Context of an Immunosuppressive Microenvironment

(2015) Javier Freire et al.   NEOPLASIA

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

(2014) Jie Dong et al.   ARCHIVES OF TOXICOLOGY

Immunosuppressive and anti-inflammatory properties of engineered nanomaterials

(2014) A N Ilinskaya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis

(2014) Christian Bode et al.   CARCINOGENESIS

Th17 can regulate silica-induced lung inflammation through an IL-1β-dependent mechanism

(2014) Laiyu Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort

(2014) Cleo Robinson et al.   LUNG CANCER

Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells

(2014) Pallab Sanpui et al.   Particle and Fibre Toxicology

Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In Vitro

(2014) Paola Italiani et al.   PLoS One

Uncoupling between Inflammatory and Fibrotic Responses to Silica: Evidence from MyD88 Knockout Mice

(2014) Sandra Lo Re et al.   PLoS One

Increased Levels of C-C Chemokine RANTES in Asbestos Exposed Workers and in Malignant Mesothelioma Patients from an Hyperendemic Area

(2014) Manola Comar et al.   PLoS One

Interferon-Tau Attenuates Uptake of Nanoparticles and Secretion of Interleukin-1β in Macrophages

(2014) Kyoko Hara et al.   PLoS One

Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice

(2014) Christian Nash Zebedeo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antioxidant Properties of Cerium Oxide Nanocrystals as a Function of Nanocrystal Diameter and Surface Coating

(2013) Seung Soo Lee et al.   ACS Nano

New Insights into Understanding the Mechanisms, Pathogenesis, and Management of Malignant Mesotheliomas

(2013) Brooke T. Mossman et al.   AMERICAN JOURNAL OF PATHOLOGY

Coal Mine Dust Lung Disease. New Lessons from an Old Exposure

(2013) Edward L. Petsonk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice

(2013) Jiali Guo et al.   ARCHIVES OF TOXICOLOGY

Lymphocyte activation in silica-exposed workers

(2013) Michelle Rocha-Parise et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice

(2013) T. P. T. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Amphibole, but not chrysotile, asbestos induces anti-nuclear autoantibodies and IL-17 in C57BL/6 mice

(2013) Aaron Ferro et al.   Journal of Immunotoxicology

Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells

(2013) Hsin-Ying Wu et al.   Particle and Fibre Toxicology

NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma

(2012) Melvyn T Chow et al.   IMMUNOLOGY AND CELL BIOLOGY

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

New insights into chronic inflammation-induced immunosuppression

(2012) Julia Kanterman et al.   SEMINARS IN CANCER BIOLOGY

Gold Nanoparticles Downregulate Interleukin-1β-Induced Pro-Inflammatory Responses

(2012) Vadim V. Sumbayev et al.   Small

Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma via Up-Regulation of Myeloid-Derived Suppressor Cells

(2012) Anna A. Shvedova et al.   Small

Aryl Hydrocarbon Receptor (AhR) Regulates Silica-Induced Inflammation But Not Fibrosis

(2012) Celine A. Beamer et al.   TOXICOLOGICAL SCIENCES

Direct Effects of Carbon Nanotubes on Dendritic Cells Induce Immune Suppression Upon Pulmonary Exposure

(2011) Alexey V. Tkach et al.   ACS Nano

Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis

(2011) Sandra Lo Re et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice

(2011) Eun-Jung Park et al.   ARCHIVES OF TOXICOLOGY

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

An increase in mouse tumor growth by anin vivoimmunomodulating effect of titanium dioxide nanoparticles

(2011) Eun-Yi Moon et al.   Journal of Immunotoxicology

Biomedical nanoparticles modulate specific CD4+T cell stimulation by inhibition of antigen processing in dendritic cells

(2011) Fabian Blank et al.   Nanotoxicology

Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures

(2011) Jennifer Kasper et al.   Particle and Fibre Toxicology

Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

Gender influences the response to experimental silica-induced lung fibrosis in mice

(2010) David M. Brass et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

(2010) Lei Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis

(2010) Yusuke Hiraku et al.   Annals of the New York Academy of Sciences

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

MexTAg mice exposed to asbestos develop cancer that faithfully replicates key features of the pathogenesis of human mesothelioma

(2010) Cleo Robinson et al.   EUROPEAN JOURNAL OF CANCER

IL-17A-Producing    T and Th17 Lymphocytes Mediate Lung Inflammation but Not Fibrosis in Experimental Silicosis

(2010) S. Lo Re et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of the immune system caused by silica and asbestos

(2010) Megumi Maeda et al.   Journal of Immunotoxicology

Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-κB and IFN-β/STAT1 pathways in RAW264.7 cells

(2010) Ji Su Ma et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice

(2010) Fangwei Liu et al.   PLoS One

Unexpected In Vivo Anti-Inflammatory Activity Observed for Simple, Surface Functionalized Poly(amidoamine) Dendrimers

(2009) Abhay S. Chauhan et al.   BIOMACROMOLECULES

Serum growth factors in asbestosis patients

(2009) Yongliang Li et al.   BIOMARKERS

Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice

(2009) L. A. Mitchell et al.   Nature Nanotechnology

Attenuation of delayed-type hypersensitivity by fullerene treatment

(2009) Keichiro Yamashita et al.   TOXICOLOGY

Lung Function and IFN-γ Levels in the Sera of Silica-Exposed Workers

(2008) Mehmet Polatli et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes

(2008) A.A. Shvedova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice

(2008) M CHOI et al.   TOXICOLOGY LETTERS