Inflammasome-Independent Leukotriene B4Production Drives Crystalline Silica–Induced Sterile Inflammation

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity

(2017) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific

(2017) Nobuo Nishijima et al.   Frontiers in Immunology

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

(2016) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cell-Based Therapy for Silicosis

(2016) Miquéias Lopes-Pacheco et al.   Stem Cells International

Treating Pulmonary Silicosis by Blocking Interleukin 1

(2015) Giulio Cavalli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth

(2015) Shuchismita R. Satpathy et al.   Nature Communications

Yersinia pestis Requires Host Rab1b for Survival in Macrophages

(2015) Michael G. Connor et al.   PLoS Pathogens

Activation of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition and Migration: Implication of a Novel Role of Inflammasome in Atherogenesis

(2014) Xiang Li et al.   PLoS One

Joint Effects of Smoking and Silicosis on Diseases to the Lungs

(2014) Lap Ah Tse et al.   PLoS One

Silica: A lung carcinogen

(2013) Kyle Steenland et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Silicosis

(2012) Chi Chiu Leung et al.   LANCET

Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy?

(2012) Rossana C. N. Melo et al.   PLoS Pathogens

Caveolae-dependent Endocytosis Is Required for Class A Macrophage Scavenger Receptor-mediated Apoptosis in Macrophages

(2011) Xu-Dong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Lipid body function in eicosanoid synthesis: An update

(2011) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

An Exposure-Response Threshold for Lung Diseases and Lung Cancer Caused by Crystalline Silica

(2011) Louis Anthony Tony Cox Jr.   RISK ANALYSIS

The role of mitogen-activated protein kinases in crystalline silica-induced cyclooxygenase-2 expression in A549 human lung epithelial cells

(2011) Makoto Tomaru et al.   TOXICOLOGY MECHANISMS AND METHODS

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

(2010) Hiroyuki Takahashi et al.   CANCER CELL

Involvement of leukotrienes in the pathogenesis of silica-induced pulmonary fibrosis in mice

(2010) Chiko Shimbori et al.   EXPERIMENTAL LUNG RESEARCH

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Leukocyte lipid bodies — Biogenesis and functions in inflammation

(2009) Patricia T. Bozza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Downregulation of cyclin D1–CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway

(2008) F SHEN et al.   CELL BIOLOGY INTERNATIONAL

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear membrane organization of leukotriene synthesis

(2008) A. K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Silica-Induced TNF-α and TGF-β1 Expression in RAW264.7 Cells are Dependent on Src-ERK/AP-1 Pathways

(2008) Xiang Li et al.   TOXICOLOGY MECHANISMS AND METHODS

Silica binding and toxicity in alveolar macrophages

(2007) Raymond F. Hamilton et al.   FREE RADICAL BIOLOGY AND MEDICINE