CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

Emerging therapeutic modalities of PARP inhibitors in breast cancer

(2018) Xin Wang et al.   CANCER TREATMENT REVIEWS

Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state

(2018) Guillaume Velasco et al.   HUMAN MOLECULAR GENETICS

Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric Instability and Facial Anomalies (ICF) syndrome

(2018) Shir Toubiana et al.   HUMAN MOLECULAR GENETICS

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

(2018) Christopher Jenness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

(2017) Shira Sagie et al.   Nature Communications

DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

(2017) David B Lyons et al.   eLife

Centromere Stability: The Replication Connection

(2017) Susan Forsburg et al.   Genes

Small RNAs Recruit Chromatin-Modifying Enzymes MMSET and Tip60 to Reconfigure Damaged DNA upon Double-Strand Break and Facilitate Repair

(2016) Qinhong Wang et al.   CANCER RESEARCH

Converging disease genes in ICF syndrome:ZBTB24controls expression ofCDCA7in mammals

(2016) Haoyu Wu et al.   HUMAN MOLECULAR GENETICS

Chromatin modification and NBS1: their relationship in DNA double-strand break repair

(2015) Yuichiro Saito et al.   GENES & GENETIC SYSTEMS

DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells

(2015) Andrea Björkman et al.   JOURNAL OF IMMUNOLOGY

The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences

(2015) Jianke Ren et al.   NUCLEIC ACIDS RESEARCH

Mutations in CDCA7 and HELLS cause immunodeficiency–centromeric instability–facial anomalies syndrome

(2015) Peter E. Thijssen et al.   Nature Communications

Replication Stress in Mammalian Cells and Its Consequences for Mitosis

(2015) Camille Gelot et al.   Genes

SWI/SNF Factors Required for Cellular Resistance to DNA Damage Include ARID1A and ARID1B and Show Interdependent Protein Stability

(2014) R. Watanabe et al.   CANCER RESEARCH

ISWI chromatin remodeling complexes in the DNA damage response

(2014) Özge Z Aydin et al.   CELL CYCLE

Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways

(2014) Weishi Yu et al.   GENOME RESEARCH

Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology

(2014) Guillaume Velasco et al.   Orphanet Journal of Rare Diseases

When a ribosome encounters a premature termination codon

(2013) Jungwook Hwang et al.   BMB Reports

The Arabidopsis Nucleosome Remodeler DDM1 Allows DNA Methyltransferases to Access H1-Containing Heterochromatin

(2013) Assaf Zemach et al.   CELL

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

Radiation-induced cellular senescence results from a slippage of long-term G2arrested cells into G1phase

(2013) Caiyong Ye et al.   CELL CYCLE

Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients

(2013) Hirohisa Nitta et al.   JOURNAL OF HUMAN GENETICS

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes

(2013) Yufeng Li et al.   NUCLEIC ACIDS RESEARCH

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

(2012) Joe Burrage et al.   JOURNAL OF CELL SCIENCE

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling

(2012) G. Smeenk et al.   JOURNAL OF CELL SCIENCE

The MYC-Associated Protein CDCA7 Is Phosphorylated by AKT To Regulate MYC-Dependent Apoptosis and Transformation

(2012) R. Montgomery Gill et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in ZBTB24 Are Associated with Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome Type 2

(2011) Jessica C. de Greef et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair

(2011) Vijayalakshmi Kari et al.   CELL CYCLE

A novel deletion inZBTB24in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2

(2011) E Chouery et al.   CLINICAL GENETICS

Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes

(2011) S.-i. Tomizawa et al.   DEVELOPMENT

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

(2011) H Ogiwara et al.   ONCOGENE

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

(2008) Shiran Yehezkel et al.   HUMAN MOLECULAR GENETICS

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

(2008) W. Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

QUMA: quantification tool for methylation analysis

(2008) Y. Kumaki et al.   NUCLEIC ACIDS RESEARCH