Solving the Telomere Replication Problem

Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin

(2016) Jigar N. Bandaria et al.   CELL

Regulating telomere length from the inside out: the replication fork model

(2016) Carol W. Greider   GENES & DEVELOPMENT

Yeast Helicase Pif1 Unwinds RNA:DNA Hybrids with Higher Processivity than DNA:DNA Duplexes

(2016) Shubeena Chib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5′ to 3′ Unfolding Directionality of DNA Secondary Structures by Replication Protein A

(2016) Layal Safa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

(2016) Delphine Benarroch-Popivker et al.   MOLECULAR CELL

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structuresin vitroand are unwound by the Pfh1 DNA helicase

(2016) Marcus Wallgren et al.   NUCLEIC ACIDS RESEARCH

Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres

(2016) Mariana C. Gadaleta et al.   PLoS Genetics

The Yin and Yang of R-loop biology

(2015) Lorenzo Costantino et al.   CURRENT OPINION IN CELL BIOLOGY

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

(2015) J. Audry et al.   EMBO JOURNAL

Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand

(2015) Daniel C. Teasley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

(2015) Grzegorz Sarek et al.   MOLECULAR CELL

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Telomere functions grounding on TERRA firma

(2015) Claus M. Azzalin et al.   TRENDS IN CELL BIOLOGY

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

TERRA and the state of the telomere

(2015) Karsten Rippe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Fun30 Chromatin Remodeler Fft3 Controls Nuclear Organization and Chromatin Structure of Insulators and Subtelomeres in Fission Yeast

(2015) Babett Steglich et al.   PLoS Genetics

Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

(2015) Chun Zhou et al.   eLife

Breaking new ground: Digging into TERRA function

(2014) André Maicher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage

(2014) Nasim Sabouri et al.   BMC BIOLOGY

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening

(2014) Karin R. McDonald et al.   DNA REPAIR

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Elucidation of the DNA End-Replication Problem in Saccharomyces cerevisiae

(2014) Julien Soudet et al.   MOLECULAR CELL

RTEL1: functions of a disease-associated helicase

(2014) Jean-Baptiste Vannier et al.   TRENDS IN CELL BIOLOGY

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1

(2014) Akila Sridhar et al.   PLoS Genetics

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

(2014) Ruobo Zhou et al.   eLife

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Genomes and G-Quadruplexes: For Better or for Worse

(2013) Madalena Tarsounas et al.   JOURNAL OF MOLECULAR BIOLOGY

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

Fission Yeast Shelterin Regulates DNA Polymerases and Rad3ATR Kinase to Limit Telomere Extension

(2013) Ya-Ting Chang et al.   PLoS Genetics

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Timeless preserves telomere length by promoting efficient DNA replication through human telomeres

(2012) Adam R. Leman et al.   CELL CYCLE

Local and global functions of Timeless and Tipin in replication fork protection

(2012) Adam R. Leman et al.   CELL CYCLE

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

(2012) N. Sabouri et al.   GENES & DEVELOPMENT

Rif1 is a global regulator of timing of replication origin firing in fission yeast

(2012) M. Hayano et al.   GENES & DEVELOPMENT

Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance

(2012) John R. Walker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

RTEL1 contributes to DNA replication and repair and telomere maintenance

(2012) Evert-Jan Uringa et al.   MOLECULAR BIOLOGY OF THE CELL

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix

(2011) Patrick G. Kaminker et al.   CELL CYCLE

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication

(2011) Raghav Chawla et al.   EMBO JOURNAL

RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

(2011) Avik K. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation

(2011) Hui-Yong Lian et al.   MOLECULAR BIOLOGY OF THE CELL

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

TERRA biogenesis, turnover and implications for function

(2010) Sascha Feuerhahn et al.   FEBS LETTERS

Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding

(2010) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles for nuclear organization in the maintenance of genome stability

(2010) Shigeki Nagai et al.   Epigenomics

Replication Timing of Human Telomeres Is Chromosome Arm–Specific, Influenced by Subtelomeric Structures and Connected to Nuclear Localization

(2010) Nausica Arnoult et al.   PLoS Genetics

Purification of Proteins Associated with Specific Genomic Loci

(2009) Jérôme Déjardin et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres

(2009) Bettina A Moser et al.   EMBO JOURNAL

Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN

(2009) N. Arnoult et al.   GENES & DEVELOPMENT

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

(2009) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation

(2009) Yuji Chikashige et al.   JOURNAL OF CELL BIOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition

(2008) Taro Masuda-Sasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Schizosaccharomyces pombe Pfh1p DNA Helicase Is Essential for the Maintenance of Nuclear and Mitochondrial DNA

(2008) S. F. Pinter et al.   MOLECULAR AND CELLULAR BIOLOGY