FTY720 preserved isletβ-cell mass by inhibiting apoptosis and increasing survival ofβ-cells in db/db mice

Antioxidant treatment may protect pancreatic beta cells through the attenuation of islet fibrosis in an animal model of type 2 diabetes

(2011) Esder Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advanced glycation end products downregulate glucokinase in mice

(2011) Hongsoo Jung et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines

(2011) Mona F. El-Azab et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

FTY720 Normalizes Hyperglycemia by Stimulating β-Cellin VivoRegeneration indb/dbMice through Regulation of Cyclin D3 and p57KIP2

(2011) Zhengshan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention, but not cure, of autoimmune diabetes in a NOD.scidtransfer model by FTY720 despite effective modulation of blood T cells

(2010) Margaret A. Morris et al.   AUTOIMMUNITY

Diabetes Prevention by Immunomodulatory FTY720 Treatment in the LEW.1AR1-iddmRat Despite Immune Cell Activation

(2010) Anne Jörns et al.   ENDOCRINOLOGY

Current Status of Islet Cell Replacement and Regeneration Therapy

(2010) Philippe A. Halban et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Imaging of  -Cell Mass and Function

(2010) M. Ichise et al.   JOURNAL OF NUCLEAR MEDICINE

Sphingosine-1-phosphate receptors: Zooming in on ligand-induced intracellular trafficking and its functional implications

(2010) Dennis Verzijl et al.   MOLECULES AND CELLS

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advanced Glycation End Products Inhibit Glucose-Stimulated Insulin Secretion through Nitric Oxide-Dependent Inhibition of CytochromecOxidase and Adenosine Triphosphate Synthesis

(2009) Zhengshan Zhao et al.   ENDOCRINOLOGY

FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice

(2008)   DIABETES OBESITY & METABOLISM