Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

(2015) John M McPartland et al.   BRITISH JOURNAL OF PHARMACOLOGY

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

(2014) Thomas F. Gamage et al.   BEHAVIOURAL PHARMACOLOGY

Type 1 Cannabinoid Receptor Ligands Display Functional Selectivity in a Cell Culture Model of Striatal Medium Spiny Projection Neurons

(2014) Robert B. Laprairie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Membrane Proximal Region of the Cannabinoid Receptor CB1 N-Terminus Can Allosterically Modulate Ligand Affinity

(2013) Jonathan F. Fay et al.   BIOCHEMISTRY

Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action

(2013) Erin E Cawston et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Co-expression of the human cannabinoid receptor coding region splice variants (hCB1) affects the function of hCB1 receptor complexes

(2013) Amina M. Bagher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans

(2013) Richard L. Anderson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients

(2013) Robert B. Laprairie et al.   JOURNAL OF NEUROIMMUNOLOGY

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

Cannabinoids increase type 1 cannabinoid receptor expression in a cell culture model of striatal neurons: Implications for Huntington's disease

(2013) Robert B. Laprairie et al.   NEUROPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Structural analogs of pyrazole and sulfonamide cannabinoids: Effects on acute food intake in mice

(2012) Jenny L. Wiley et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor

(2012) Francesco Piscitelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release – Species differences

(2012) Samira G. Ferreira et al.   NEUROCHEMISTRY INTERNATIONAL

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

(2012) A. C. Campos et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

(2011) N. J. Smith et al.   MOLECULAR PHARMACOLOGY

Physical and functional interaction between CB1cannabinoid receptors and β2-adrenoceptors

(2010) Brian D Hudson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist

(2010) Jenny L. Wiley et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Cannabinoid 1–Receptor Silent Antagonist O-2050 Attenuates Preference for High-Fat Diet and Activated Astrocytes in Mice

(2010) Sei Higuchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

(2008) Roger G. Pertwee   ADDICTION BIOLOGY

Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors

(2008) Meritxell Canals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabidiol potentiates pharmacological effects of Δ9-tetrahydrocannabinol via CB1 receptor-dependent mechanism

(2007) Kazuhide Hayakawa et al.   BRAIN RESEARCH

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

(2007) J G Horswill et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

(2007) A Thomas et al.   BRITISH JOURNAL OF PHARMACOLOGY