Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12

Cannabidiol: State of the art and new challenges for therapeutic applications

(2017) Simona Pisanti et al.   PHARMACOLOGY & THERAPEUTICS

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

(2017) Georgia Watt et al.   Frontiers in Pharmacology

Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature

(2017) Stéphanie Le Gras et al.   Scientific Reports

Nesfatin-1: functions and physiology of a novel regulatory peptide

(2016) Riccardo Dore et al.   JOURNAL OF ENDOCRINOLOGY

A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients

(2016) Serena Martire et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased susceptibility of G-protein coupled receptor 6 deficient mice to MPTP neurotoxicity

(2016) Patrick Oeckl et al.   NEUROSCIENCE

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons

(2016) Tatsuhiro Miyagi et al.   PLoS One

Disease-modifying treatments for multiple sclerosis - a review of approved medications

(2015) Ø. Torkildsen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models

(2015) Yunhong Huang et al.   Science Translational Medicine

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

(2015) Grzegorz Godlewski et al.   Scientific Reports

Emerging and Novel Functions of Complement Protein C1q

(2015) Lubna Kouser et al.   Frontiers in Immunology

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

(2015) Adam L. Martin et al.   PLoS One

The identification of GPR3 inverse agonist AF64394; The first small molecule inhibitor of GPR3 receptor function

(2014) Thomas Jensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest

(2014) Nancy Nader et al.   DEVELOPMENTAL BIOLOGY

G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease

(2014) Patrick Oeckl et al.   EXPERIMENTAL NEUROLOGY

Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

(2014) Shigeru Tanaka et al.   NEUROBIOLOGY OF DISEASE

Anatomical Transcriptome of G Protein-Coupled Receptors Leads to the Identification of a Novel Therapeutic Candidate GPR52 for Psychiatric Disorders

(2014) Hidetoshi Komatsu et al.   PLoS One

The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte

(2013) Rong Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells

(2013) Katie M. Lowther et al.   PLoS One

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

(2012) Nicole H. Rogers et al.   AGING CELL

Molecular control of oogenesis

(2012) Flor Sánchez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro

(2012) Konstantin Khodosevich et al.   BMC NEUROSCIENCE

The orphan receptor GPR3 modulates the early phases of cocaine reinforcement

(2012) Clara Tourino et al.   BRITISH JOURNAL OF PHARMACOLOGY

How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis

(2012) Anne G. E. Collins et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

(2012) Marie E. Benoit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors

(2012) Bao-le Zhang et al.   Journal of Zhejiang University-SCIENCE B

Involvement of GPR12 in the regulation of cell proliferation and survival

(2012) Xiaoming Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

(2012) Amantha Thathiah et al.   NATURE MEDICINE

The G Protein Coupled Receptor 3 Is Involved in cAMP and cGMP Signaling and Maintenance of Meiotic Arrest in Porcine Oocytes

(2012) Cai-Rong Yang et al.   PLoS One

Metabolic Parameters and Emotionality Are Little Affected in G-Protein Coupled Receptor 12 (Gpr12) Mutant Mice

(2012) Elisabeth Frank et al.   PLoS One

Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells

(2011) Xiaoming Lu et al.   BRAIN RESEARCH BULLETIN

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

(2011) M. E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Biomarkers of disease activity in multiple sclerosis

(2011) Jerome J. Graber et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Is Older Colder or Colder Older? The Association of Age With Body Temperature in 18,630 Individuals

(2011) J. Waalen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception

(2011) Jessica Ruiz-Medina et al.   NEUROPHARMACOLOGY

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

Huntington's disease: a clinical review

(2011) Raymund A.C. Roos   Orphanet Journal of Rare Diseases

Reassessment of Blood Gene Expression Markers for the Prognosis of Relapsing-Remitting Multiple Sclerosis

(2011) Michael Hecker et al.   PLoS One

Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest

(2011) Katie M Lowther et al.   REPRODUCTION

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

Therapy of MS

(2010) Reza Vosoughi et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap

(2010) Paolo Calabresi et al.   LANCET NEUROLOGY

Neurogenetics and Pharmacology of Learning, Motivation and Cognition

(2010) Michael J Frank et al.   NEUROPSYCHOPHARMACOLOGY

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BDNF-Mediated Cerebellar Granule Cell Development Is Impaired in Mice Null for CaMKK2 or CaMKIV

(2009) M. Kokubo et al.   JOURNAL OF NEUROSCIENCE

GPR3 Receptor, a Novel Actor in the Emotional-Like Responses

(2009) Olga Valverde et al.   PLoS One

The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells during Postnatal Development

(2009) Shigeru Tanaka et al.   PLoS One

GPR3 may not be a potential candidate gene for premature ovarian failure

(2009) Sirui Zhou et al.   REPRODUCTIVE BIOMEDICINE ONLINE

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

GPR12 Selections of the metabolites from an endophytic Streptomyces sp. Asociated with Cistanches deserticola

(2008) Zhen-Jian Lin et al.   ARCHIVES OF PHARMACAL RESEARCH

Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway1

(2008) Andrea DiLuigi et al.   BIOLOGY OF REPRODUCTION

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific

(2008) Elisabetta Aldieri et al.   CURRENT DRUG METABOLISM

A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes

(2008) Diana Ríos-Cardona et al.   DEVELOPMENTAL BIOLOGY

Constitutively active GPR6 is located in the intracellular compartments

(2008) Shalini Padmanabhan et al.   FEBS LETTERS

Oocyte-specific G-protein–coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report)

(2008) Ertug Kovanci et al.   FERTILITY AND STERILITY

The complement cascade: Yin-Yang in neuroinflammation - neuro-protection and -degeneration

(2008) Jessy John Alexander et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Striatal Plasticity and Basal Ganglia Circuit Function

(2008) Anatol C. Kreitzer et al.   NEURON