Functionally Important Amino Acid Residues in the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel - An Overview of the Current Mutational Data

Resiniferatoxin Mediated Ablation of TRPV1+ Neurons Removes TRPA1 as Well

(2014) László Pecze et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Divalent Heavy Metal Cations Block the TRPV1 Ca2+ Channel

(2012) László Pecze et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The functions of TRPA1 and TRPV1: moving away from sensory nerves

(2012) ES Fernandes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

(2012) Yuanyuan Cui et al.   JOURNAL OF GENERAL PHYSIOLOGY

The role of chemosensitive afferent nerves and TRP ion channels in the pathomechanism of headaches

(2012) Mária Dux et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Integrative Binding Sites within Intracellular Termini of TRPV1 Receptor

(2012) Lenka Grycova et al.   PLoS One

Multisteric TRPV1 nocisensor: a target for analgesics

(2012) János Szolcsányi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice

(2011) Noriyuki Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dissecting TRPV1: Lessons to be learned?

(2011) Christian Grimm et al.   Channels

The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil

(2011) Wouter Everaerts et al.   CURRENT BIOLOGY

The biophysical and molecular basis of TRPV1 proton gating

(2011) Eduardo Aneiros et al.   EMBO JOURNAL

Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

(2011) Giovanni Picazo-Juárez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of the PIP2 Sensor of TRPV1 Ion Channels

(2011) Carmen A. Ufret-Vincenty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies

(2011) Jin Hee Lee et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

(2011) D. J. Cavanaugh et al.   JOURNAL OF NEUROSCIENCE

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

(2010) Elizabeth S. Fernandes et al.   ARTHRITIS AND RHEUMATISM

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Nociception, neurogenic inflammation and thermoregulation in TRPV1 knockdown transgenic mice

(2010) Dániel Márton Tóth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TRPV1 Function in Health and Disease

(2010) John P.M. White et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Distinct Modulations of Human Capsaicin Receptor by Protons and Magnesium through Different Domains

(2010) Shu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels

(2010) Stepana Boukalova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Inhibition of glucosylceramide synthase reversibly decreases the capsaicin-induced activation and TRPV1 expression of cultured dorsal root ganglion neurons

(2010) Péter Sántha et al.   PAIN

TRPV1: On the Road to Pain Relief

(2010) Andres Jara-Oseguera et al.   Current Molecular Pharmacology

Intragastric Administration of TRPV1, TRPV3, TRPM8, and TRPA1 Agonists Modulates Autonomic Thermoregulation in Different Manners in Mice

(2009) Yukiko MASAMOTO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Non-Pungent Capsaicin Analogs (Capsinoids) Increase Metabolic Rate and Enhance ThermogenesisviaGastrointestinal TRPV1 in Mice

(2009) Fuminori KAWABATA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Roles of transient receptor potential channels in pain

(2009) Cheryl L. Stucky et al.   BRAIN RESEARCH REVIEWS

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca 2+ -Activated K + Channels

(2009) Scott Earley et al.   CIRCULATION RESEARCH

TRP Channels and Pain

(2009) Daniel Cortright et al.   CURRENT PHARMACEUTICAL DESIGN

Effect of lipid raft disruption on TRPV1 receptor activation of trigeminal sensory neurons and transfected cell line

(2009) Éva Szőke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cholesterol and Kir channels

(2009) Irena Levitan   IUBMB LIFE

Pharmacology of Vanilloid Transient Receptor Potential Cation Channels

(2009) J. Vriens et al.   MOLECULAR PHARMACOLOGY

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice Fed a High-fat Diet

(2009) Ji-Hye Kang et al.   Obesity

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

(2009) A. A. Romanovsky et al.   PHARMACOLOGICAL REVIEWS

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

(2009) Khadija Alawi et al.   PHARMACOLOGY & THERAPEUTICS

Structure–functional intimacies of transient receptor potential channels

(2009) Ramon Latorre et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Interaction with Phosphoinositides Confers Adaptation onto the TRPV1 Pain Receptor

(2009) Jing Yao et al.   PLOS BIOLOGY

Ionic interactions are essential for TRPV1 C-terminus binding to calmodulin

(2008) Lenka Grycova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The concept of neurogenic inflammation

(2008) Pierangelo Geppetti et al.   BJU INTERNATIONAL

Peripheral TRPV1 Receptors As Targets for Drug Development: New Molecules and Mechanisms

(2008) Arpad Szallasi et al.   CURRENT PHARMACEUTICAL DESIGN

17β-Estradiol Activates Estrogen Receptor β-Signalling and Inhibits Transient Receptor Potential Vanilloid Receptor 1 Activation by Capsaicin in Adult Rat Nociceptor Neurons

(2008) Shenghong Xu et al.   ENDOCRINOLOGY

Drugs and their molecular targets: an updated overview

(2008) Yves Landry et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

(2008) Nuria Tamayo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Expression of Transient Receptor Potential Vanilloid-Related Channels in Chronically Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

(2008) Yue Xiu Wang et al.   JOURNAL OF MEMBRANE BIOLOGY

Molecular Modeling of the Full-length Human TRPV1 Channel in Closed and Desensitized States

(2008) G. Fernández-Ballester et al.   JOURNAL OF MEMBRANE BIOLOGY

TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

(2008) Jeffrey J. Lawson et al.   JOURNAL OF PAIN

Tissue-Specific Regulation of Microvascular Diameter: Opposite Functional Roles of Neuronal and Smooth Muscle Located Vanilloid Receptor-1

(2008) T. Kark et al.   MOLECULAR PHARMACOLOGY

A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic

(2008) Héctor Salazar et al.   NATURE NEUROSCIENCE

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

(2008) Benjamin R. Myers et al.   NEURON

Capsaicin-induced neuronal death and proliferation of the primary sensory neurons located in the nodose ganglia of adult rats

(2008) K. Czaja et al.   NEUROSCIENCE

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN

Structure of TRPV1 channel revealed by electron cryomicroscopy

(2008) V. Y. Moiseenkova-Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide

(2008) Dan Luo et al.   REGULATORY PEPTIDES

Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1

(2008) Narender R. Gavva   TRENDS IN PHARMACOLOGICAL SCIENCES

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

(2005) Shang-Zhong Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY