CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation

(2018) Penghui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of novel inhibitors for Leishmania nucleoside diphosphatase kinase (NDK) based on its structural and functional characterization

(2017) Arjun K. Mishra et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction

(2017) Yu-Qing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico identification of inhibitors of ribose 5-phosphate isomerase from Trypanosoma cruzi using ligand and structure based approaches

(2017) Vanessa de V. C. Sinatti et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models

(2017) Chaoran Yin et al.   MOLECULAR THERAPY

Structure, kinetic characterization and subcellular localization of the two ribulose 5-phosphate epimerase isoenzymes from Trypanosoma cruzi

(2017) Soledad Natalia Gonzalez et al.   PLoS One

Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

(2017) Xiaoguang Li et al.   Frontiers in Pharmacology

CheckMyMetal: a macromolecular metal-binding validation tool

(2017) Heping Zheng et al.   Acta Crystallographica Section D-Structural Biology

Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer

(2017) Huân M. Ngô et al.   Scientific Reports

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Understanding Toxoplasmosis in the United States Through “Large Data” Analyses

(2016) Joseph Lykins et al.   CLINICAL INFECTIOUS DISEASES

Membrane skeletal association and post-translational allosteric regulation ofToxoplasma gondiiGAPDH1

(2016) Rashmi Dubey et al.   MOLECULAR MICROBIOLOGY

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections

(2016) Martin McPhillie et al.   Scientific Reports

Structural and Functional Divergence of the Aldolase Fold in Toxoplasma gondii

(2015) Michelle L. Tonkin et al.   JOURNAL OF MOLECULAR BIOLOGY

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

(2015) Emily P. Thi et al.   NATURE

Gene3D: expanding the utility of domain assignments

(2015) Su Datt Lam et al.   NUCLEIC ACIDS RESEARCH

Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis

(2015) Plínio Salmazo Vieira et al.   BMC STRUCTURAL BIOLOGY

The structure of bradyzoite-specific enolase fromToxoplasma gondiireveals insights into its dual cytoplasmic and nuclear functions

(2015) Jiapeng Ruan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Safety and Pharmacokinetic Profiles of Phosphorodiamidate Morpholino Oligomers with Activity against Ebola Virus and Marburg Virus: Results of Two Single-Ascending-Dose Studies

(2014) Alison E. Heald et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A New Subfamily of Polyphosphate Kinase 2 (Class III PPK2) Catalyzes both Nucleoside Monophosphate Phosphorylation and Nucleoside Diphosphate Phosphorylation

(2014) Kei Motomura et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

CATH: comprehensive structural and functional annotations for genome sequences

(2014) Ian Sillitoe et al.   NUCLEIC ACIDS RESEARCH

Toxoplasmosis – A Global Threat. Correlation of Latent Toxoplasmosis with Specific Disease Burden in a Set of 88 Countries

(2014) Jaroslav Flegr et al.   PLoS One

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

(2014) Tsunamasa Watanabe et al.   Scientific Reports

Vitamin B6-Dependent Enzymes in the Human Malaria ParasitePlasmodium falciparum: A Druggable Target?

(2014) Thales Kronenberger et al.   Biomed Research International

Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii TachyzoitesIn VitroandIn Vivo

(2013) Ying Zhou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The global burden of congenital toxoplasmosis: a systematic review

(2013) Paul R Torgerson et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

PDBsum additions

(2013) Tjaart A. P. de Beer et al.   NUCLEIC ACIDS RESEARCH

In vitro gene silencing of independent phosphoglycerate mutase (iPGM) in the filarial parasite Brugia malayi

(2013) Prashant Kumar Singh et al.   Infectious Diseases of Poverty

Lipid nanoparticle delivery systems for siRNA-based therapeutics

(2013) C. Wan et al.   Drug Delivery and Translational Research

Prematurity and Severity Are Associated With Toxoplasma gondii Alleles (NCCCTS, 1981–2009)

(2012) Rima McLeod et al.   CLINICAL INFECTIOUS DISEASES

Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum

(2012) Y. Augagneur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections

(2012) B.-S. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An ensemble of structures ofBurkholderia pseudomallei2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

(2011) Douglas R. Davies et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Extracellular Toxoplasma gondii tachyzoites do not require carbon source uptake for ATP maintenance, gliding motility and invasion in the first hour of their extracellular life

(2011) San San Lin et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

(2011) Sebahattin Cirak et al.   LANCET

TDR Targets: a chemogenomics resource for neglected diseases

(2011) M. P. Magarinos et al.   NUCLEIC ACIDS RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Conversion of d-ribulose 5-phosphate to d-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE

(2010) Wenguang Liang et al.   FASEB JOURNAL

Redox Regulation of Plasmodium falciparum Ornithine δ-Aminotransferase

(2010) Esther Jortzik et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

(2010) Gregory J. Crowther et al.   PLoS Neglected Tropical Diseases

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Advances and pitfalls of protein structural alignment

(2009) Hitomi Hasegawa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal contacts as nature's docking solutions

(2009) Evgeny Krissinel   JOURNAL OF COMPUTATIONAL CHEMISTRY

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

(2009) Maria Kinali et al.   LANCET NEUROLOGY

Poisoning Pyridoxal 5-Phosphate-Dependent Enzymes: A New Strategy to Target the Malaria Parasite Plasmodium falciparum

(2009) Ingrid B. Müller et al.   PLoS One

Identification of Proteins Targeted by the Thioredoxin Superfamily in Plasmodium falciparum

(2009) Nicole Sturm et al.   PLoS Pathogens

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

Host Cell Egress and Invasion Induce Marked Relocations of Glycolytic Enzymes in Toxoplasma gondii Tachyzoites

(2008) Sebastien Pomel et al.   PLoS Pathogens

Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages

(2007) Bala Krishna Kolli et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY