Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach

targetTB: A target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis

(2012) Karthik Raman et al.   BMC Systems Biology

Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes

(2010) Maria A Doyle et al.   BMC GENOMICS

Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs

(2010) Ethan A. Merritt et al.   JOURNAL OF MOLECULAR BIOLOGY

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

(2010) Elizabeth R. Sharlow et al.   PLoS Neglected Tropical Diseases

Two pathways for cysteine biosynthesis inLeishmania major

(2009) Roderick A. M. Williams et al.   BIOCHEMICAL JOURNAL

Shape- and Chemical Feature-Based 3D-Pharmacophore Model Generation and Virtual Screening: Identification of Potential Leads forP. falciparumDHFR Enzyme Inhibition

(2009) Legesse Adane et al.   Chemical Biology & Drug Design

Design, development, synthesis, and docking analysis of 2′-substituted triclosan analogs as inhibitors forPlasmodium falciparumEnoyl-ACP reductase

(2009) Neha Kapoor et al.   IUBMB LIFE

ChEMBL. An interview with John Overington, team leader, chemogenomics at the European Bioinformatics Institute Outstation of the European Molecular Biology Laboratory (EMBL-EBI)

(2009) Wendy A. Warr   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Structural Basis for the Inhibition of Mycobacterium tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors

(2009) Mikael T. Nilsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei

(2009) Ana Judith Cáceres et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni

(2009) Conor R. Caffrey et al.   PLoS One

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

Structure-Based Design of a Novel Class of Potent Inhibitors of InhA, the Enoyl Acyl Carrier Protein Reductase fromMycobacterium Tuberculosis: A Computer Modelling Approach

(2008) Gita Subba Rao et al.   Chemical Biology & Drug Design

Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

(2008) Arvind K Chavali et al.   Molecular Systems Biology

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

SchistoDB: a Schistosoma mansoni genome resource

(2008) A. Zerlotini et al.   NUCLEIC ACIDS RESEARCH

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH

MODBASE, a database of annotated comparative protein structure models and associated resources

(2008) U. Pieper et al.   NUCLEIC ACIDS RESEARCH

FlyBase: enhancing Drosophila Gene Ontology annotations

(2008) S. Tweedie et al.   NUCLEIC ACIDS RESEARCH

BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009

(2008) A. Chang et al.   NUCLEIC ACIDS RESEARCH

A combined transcriptome and proteome survey of malaria parasite liver stages

(2008) A. S. Tarun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of Escherichia coli serine acetyltransferase block proliferation of Entamoeba histolytica trophozoites

(2007) S AGARWAL et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY