The FHIT gene product: tumor suppressor and genome “caretaker”

Nucleotide metabolism, oncogene-induced senescence and cancer

(2015) Katherine M. Aird et al.   CANCER LETTERS

WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications

(2014) Aliza Gardenswartz et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Common chromosome fragile sites in human and murine epithelial cells andFHIT/FRA3Bloss-induced global genome instability

(2013) Seyed Ali Hosseini et al.   GENES CHROMOSOMES & CANCER

Fhit Delocalizes Annexin A4 from Plasma Membrane to Cytosol and Sensitizes Lung Cancer Cells to Paclitaxel

(2013) Eugenio Gaudio et al.   PLoS One

Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

(2013) Satoshi Miuma et al.   PLoS One

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

(2012) S. I. Nikolaev et al.   CANCER RESEARCH

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells

(2012) Margaret A. Young et al.   Cell Stem Cell

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

(2012) Marta B Davidson et al.   EMBO JOURNAL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

(2012) Wayne R. Austin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

Evolution of the cancer genome

(2012) Lucy R. Yates et al.   NATURE REVIEWS GENETICS

Recovery of Arrested Replication Forks by Homologous Recombination Is Error-Prone

(2012) Ismail Iraqui et al.   PLoS Genetics

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

(2012) Joshua C. Saldivar et al.   PLoS Genetics

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

(2012) Diana D. Villarreal et al.   PLoS Genetics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Break-Induced Replication Is Highly Inaccurate

(2011) Angela Deem et al.   PLOS BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutator phenotype in cancer: Origin and consequences

(2010) Lawrence A. Loeb   SEMINARS IN CANCER BIOLOGY

On the karyotypic origin and evolution of cancer cells

(2009) Joshua M. Nicholson et al.   CANCER GENETICS AND CYTOGENETICS

Fragile gene product, Fhit, in oxidative and replicative stress responses

(2009) Hiroshi Okumura et al.   CANCER SCIENCE

Fhit regulates invasion of lung tumor cells

(2009) A Joannes et al.   ONCOGENE

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

(2009) A. Rimessi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Instability Is Not a Requirement for Tumor Development

(2008) W. Bodmer et al.   CANCER RESEARCH

Correlation of Fragile Histidine Triad (Fhit) Protein Structural Features with Effector Interactions and Biological Functions

(2008) Flavia Pichiorri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fhit Interaction with Ferredoxin Reductase Triggers Generation of Reactive Oxygen Species and Apoptosis of Cancer Cells

(2008) Francesco Trapasso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE