Journal
JOURNAL OF BIOTECHNOLOGY
Volume 189, Issue -, Pages 150-153Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2014.09.008
Keywords
Synthetic biology; Gene control; Protein engineering; Optogenetic sun cream profiler
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Light-dependent gene regulation systems are advantageous as they allow for precise spatio-temporal control of target gene expression. In this paper, we present a novel UV-A and blue-light-inducible gene control system that is based on the light-dependent heterodimerization of the CRY2 and C1BN domains. Upon their interaction, a transcription factor is released from the cell membrane and initiates target gene expression. Capitalizing on that, sun cream UV-A protection properties were measured intracellularly. (C) 2014 Elsevier B.V. All rights reserved.
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