Mammalian synthetic biology: emerging medical applications

Engineered T cells for cancer therapy

(2014) Carl H. June et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Bacteriophage-based synthetic biology for the study of infectious diseases

(2014) Robert J Citorik et al.   CURRENT OPINION IN MICROBIOLOGY

Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells

(2014) Lior Nissim et al.   MOLECULAR CELL

CRISPR transcriptional repression devices and layered circuits in mammalian cells

(2014) Samira Kiani et al.   NATURE METHODS

CRISPR–Cas systems: beyond adaptive immunity

(2014) Edze R. Westra et al.   NATURE REVIEWS MICROBIOLOGY

A brief history of synthetic biology

(2014) D. Ewen Cameron et al.   NATURE REVIEWS MICROBIOLOGY

Synthetic biology in mammalian cells: next generation research tools and therapeutics

(2014) Florian Lienert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antagonistic control of a dual-input mammalian gene switch by food additives

(2014) Mingqi Xie et al.   NUCLEIC ACIDS RESEARCH

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Directed evolution of a synthetic RNA–protein module to create a new translational switch

(2013) Tomoaki Hara et al.   CHEMICAL COMMUNICATIONS

Synthetic mammalian gene circuits for biomedical applications

(2013) Haifeng Ye et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Predict Drug-Protein Interaction in Cellular Networking

(2013) Xuan Xiao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology

(2013) Michael Kalos et al.   IMMUNITY

Protein Scaffold-Activated Protein Trans-Splicing in Mammalian Cells

(2013) Daniel F. Selgrade et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bile acid-controlled transgene expression in mammalian cells and mice

(2013) Katrin Rössger et al.   METABOLIC ENGINEERING

Synthetic analog computation in living cells

(2013) Ramiz Daniel et al.   NATURE

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

CRISPR RNA–guided activation of endogenous human genes

(2013) Morgan L Maeder et al.   NATURE METHODS

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic mammalian trigger-controlled bipartite transcription factors

(2013) Marc Folcher et al.   NUCLEIC ACIDS RESEARCH

Amplifying Genetic Logic Gates

(2013) J. Bonnet et al.   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Controlling Mammalian Gene Expression by Allosteric Hepatitis Delta Virus Ribozymes

(2013) Yoko Nomura et al.   ACS Synthetic Biology

Tunable and Multifunctional Eukaryotic Transcription Factors Based on CRISPR/Cas

(2013) Fahim Farzadfard et al.   ACS Synthetic Biology

Orthogonal control of endogenous gene expression in mammalian cells using synthetic ligands

(2012) Jing Liang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Synthetic memory circuits for tracking human cell fate

(2012) D. R. Burrill et al.   GENES & DEVELOPMENT

Destabilizing Domains Derived from the Human Estrogen Receptor

(2012) Yusuke Miyazaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic two-way communication between mammalian cells

(2012) William Bacchus et al.   NATURE BIOTECHNOLOGY

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses

(2012) Patrick Ketzer et al.   NUCLEIC ACIDS RESEARCH

A tunable zinc finger-based framework for Boolean logic computation in mammalian cells

(2012) Jason J. Lohmueller et al.   NUCLEIC ACIDS RESEARCH

Modular control of multiple pathways using engineered orthogonal T7 polymerases

(2012) Karsten Temme et al.   NUCLEIC ACIDS RESEARCH

Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

(2012) H. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice

(2012) S. A. Stanley et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

From gene switches to mammalian designer cells: present and future prospects

(2012) Simon Ausländer et al.   TRENDS IN BIOTECHNOLOGY

CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation

(2011) Devaki Bhaya et al.   Annual Review of Genetics

Reversing Bacterial Resistance to Antibiotics by Phage-Mediated Delivery of Dominant Sensitive Genes

(2011) Rotem Edgar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tunable Signal Processing in Synthetic MAP Kinase Cascades

(2011) Ellen C. O'Shaughnessy et al.   CELL

Synthetic Biology: Modulating the MAP Kinase Module

(2011) Lee Bardwell   CURRENT BIOLOGY

Benzoate X receptor zinc-finger gene switches for drug-inducible regulation of transcription

(2011) L J Schwimmer et al.   GENE THERAPY

Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

(2011) Taavi K Neklesa et al.   Nature Chemical Biology

Small-molecule displacement of a cryptic degron causes conditional protein degradation

(2011) Kimberly M Bonger et al.   Nature Chemical Biology

Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells

(2011) David Ausländer et al.   NUCLEIC ACIDS RESEARCH

The food additive vanillic acid controls transgene expression in mammalian cells and mice

(2011) Marc Gitzinger et al.   NUCLEIC ACIDS RESEARCH

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity

(2011) F.-S. Liang et al.   Science Signaling

Inteins, valuable genetic elements in molecular biology and biotechnology

(2010) Skander Elleuche et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mathematical modeling of cell cycle regulation in response to DNA damage: Exploring mechanisms of cell-fate determination

(2010) Kazunari Iwamoto et al.   BIOSYSTEMS

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

(2010) Mari Iwamoto et al.   CHEMISTRY & BIOLOGY

Stabilization and Regression of Coronary Plaques Treated With Pitavastatin Proven by Angioscopy and Intravascular Ultrasound

(2010) Kazuhisa Kodama et al.   CIRCULATION JOURNAL

A comparative analysis of synthetic genetic oscillators

(2010) O. Purcell et al.   Journal of the Royal Society Interface

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression

(2010) Simon Ausländer et al.   Molecular BioSystems

A tunable dual-promoter integrator for targeting of cancer cells

(2010) Lior Nissim et al.   Molecular Systems Biology

Five hard truths for synthetic biology

(2010) Roberta Kwok   NATURE

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

(2010) Christian Kemmer et al.   NATURE BIOTECHNOLOGY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Synthetic biology: applications come of age

(2010) Ahmad S. Khalil et al.   NATURE REVIEWS GENETICS

An engineered mammalian band-pass network

(2010) D. Greber et al.   NUCLEIC ACIDS RESEARCH

A synthetic low-frequency mammalian oscillator

(2010) Marcel Tigges et al.   NUCLEIC ACIDS RESEARCH

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing

(2010) Chase L. Beisel et al.   NUCLEIC ACIDS RESEARCH

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

(2010) Y. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

(2010) S. J. Culler et al.   SCIENCE

The Chemical Biology of Aptamers

(2009) Günter Mayer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-induced sequestering of branchpoint sequence allows conditional control of splicing

(2009) Dong-Suk Kim et al.   BMC MOLECULAR BIOLOGY

Engineering of Synthetic Mammalian Gene Networks

(2009) Wilfried Weber et al.   CHEMISTRY & BIOLOGY

Recent advances in mammalian synthetic biology—design of synthetic transgene control networks

(2009) Marcel Tigges et al.   CURRENT OPINION IN BIOTECHNOLOGY

Application of λ Red recombination system to Vibrio cholerae genetics: Simple methods for inactivation and modification of chromosomal genes

(2009) Shouji Yamamoto et al.   GENE

Conditional RNA Interference Mediated by Allosteric Ribozyme

(2009) Deepak Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A biotin-triggered genetic switch in mammalian cells and mice

(2009) Wilfried Weber et al.   METABOLIC ENGINEERING

A tunable synthetic mammalian oscillator

(2009) Marcel Tigges et al.   NATURE

Induction of protein-protein interactions in live cells using light

(2009) Masayuki Yazawa et al.   NATURE BIOTECHNOLOGY

Synthetic translational regulation by an L7Ae–kink-turn RNP switch

(2009) Hirohide Saito et al.   Nature Chemical Biology

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

A synthetic mammalian electro-genetic transcription circuit

(2009) W. Weber et al.   NUCLEIC ACIDS RESEARCH

Delay-Induced Degrade-and-Fire Oscillations in Small Genetic Circuits

(2009) William Mather et al.   PHYSICAL REVIEW LETTERS

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

(2009) M. Gitzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traceless protein splicing utilizing evolved split inteins

(2009) S. W. Lockless et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Gene Networks That Count

(2009) A. E. Friedland et al.   SCIENCE

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa

(2008) Biliana Lesic et al.   BMC MOLECULAR BIOLOGY

Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches

(2008) L Magnenat et al.   GENE THERAPY

A fast, robust and tunable synthetic gene oscillator

(2008) Jesse Stricker et al.   NATURE

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

(2008) D. Greber et al.   NUCLEIC ACIDS RESEARCH

Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit

(2008) Tobias May et al.   PLoS One

A synthetic mammalian gene circuit reveals antituberculosis compounds

(2008) W. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics

(2008) C. J. Bashor et al.   SCIENCE