Protein design in biological networks: from manipulating the input to modifying the output

Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase toward Its Death Receptors†

(2009) Carlos R. Reis et al.   BIOCHEMISTRY

Designing New Cellular Signaling Pathways

(2009) Peter M. Pryciak   CHEMISTRY & BIOLOGY

Computational tools for designing and engineering biocatalysts

(2009) Jiri Damborsky et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-Based Prediction of the Saccharomyces cerevisiae SH3–Ligand Interactions

(2009) Gregorio Fernandez-Ballester et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of protein-interaction specificity gives selective bZIP-binding peptides

(2009) Gevorg Grigoryan et al.   NATURE

Engineering transcription factors with novel DNA-binding specificity using comparative genomics

(2009) Tasha A. Desai et al.   NUCLEIC ACIDS RESEARCH

Rapid Mutation of Endogenous Zebrafish Genes Using Zinc Finger Nucleases Made by Oligomerized Pool ENgineering (OPEN)

(2009) Jonathan E. Foley et al.   PLoS One

Computational structure-based redesign of enzyme activity

(2009) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analyzing Protein Interaction Networks Using Structural Information

(2008) Christina Kiel et al.   Annual Review of Biochemistry

Macromolecular Modeling with Rosetta

(2008) Rhiju Das et al.   Annual Review of Biochemistry

New Redesigned Zinc-Finger Proteins: Design Strategy and Its Application

(2008) Shigeru Negi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Designed metal-binding sites in biomolecular and bioinorganic interactions

(2008) J MATTHEWS et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

DR4-selective Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Variants Obtained by Structure-based Design

(2008) Vicente Tur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational Redesign of the SHV-1 β-Lactamase/β-Lactamase Inhibitor Protein Interface

(2008) Kimberly A. Reynolds et al.   JOURNAL OF MOLECULAR BIOLOGY

Computational Redesign of a Protein–Protein Interface for High Affinity and Binding Specificity Using Modular Architecture and Naturally Occurring Template Fragments

(2008) V. Potapov et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

(2008) Morgan L. Maeder et al.   MOLECULAR CELL

Zinc-finger Nucleases: The Next Generation Emerges

(2008) Toni Cathomen et al.   MOLECULAR THERAPY

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

Unexpected failure rates for modular assembly of engineered zinc fingers

(2008) Cherie L Ramirez et al.   NATURE METHODS

Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences

(2008) Emmanuel Fajardo-Sanchez et al.   NUCLEIC ACIDS RESEARCH

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE

Genome-Wide Prediction of SH2 Domain Targets Using Structural Information and the FoldX Algorithm

(2008) Ignacio E. Sánchez et al.   PLoS Computational Biology