Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Low Charge and Reduced Mobility of Membrane Protein Complexes Has Implications for Calibration of Collision Cross Section Measurements

(2016) Timothy M. Allison et al.   ANALYTICAL CHEMISTRY

Increasing Ubiquitin Ion Resistance to Unfolding in the Gas Phase Using Chloride Adduction: Preserving More “Native-Like” Conformations Despite Collisional Activation

(2016) Nicole D. Wagner et al.   ANALYTICAL CHEMISTRY

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

A sliding selectivity scale for lipid binding to membrane proteins

(2016) Michael Landreh et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

High-resolution mass spectrometry of small molecules bound to membrane proteins

(2016) Joseph Gault et al.   NATURE METHODS

Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters

(2016) Mathieu Coincon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters

(2016) Mathieu Coincon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Collision Induced Unfolding of Intact Antibodies: Rapid Characterization of Disulfide Bonding Patterns, Glycosylation, and Structures

(2015) Yuwei Tian et al.   ANALYTICAL CHEMISTRY

Different Modes of Lipid Binding to Membrane Proteins Probed by Mass Spectrometry

(2015) Chérine Bechara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NhaA antiporter functions using 10 helices, and an additional 2 contribute to assembly/stability

(2015) Etana Padan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collisional unfolding of multiprotein complexes reveals cooperative stabilization upon ligand binding

(2015) Shuai Niu et al.   PROTEIN SCIENCE

Collision Cross Sections for Structural Proteomics

(2015) Erik G. Marklund et al.   STRUCTURE

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

(2015) Timothy M. Allison et al.   Nature Communications

Mechanism of Na+-dependent citrate transport from the structure of an asymmetrical CitS dimer

(2015) David Wöhlert et al.   eLife

Flexible membrane proteins: functional dynamics captured by mass spectrometry

(2014) Min Zhou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

MemStar: A one-shotEscherichia coli-based approach for high-level bacterial membrane protein production

(2014) Chiara Lee et al.   FEBS LETTERS

Crystal structure of the sodium–proton antiporter NhaA dimer and new mechanistic insights

(2014) Chiara Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Functional and structural dynamics of NhaA, a prototype for Na+ and H+ antiporters, which are responsible for Na+ and H+ homeostasis in cells

(2013) Etana Padan   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

A two-domain elevator mechanism for sodium/proton antiport

(2013) Chiara Lee et al.   NATURE

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

Intrinsically Disordered p53 and Its Complexes Populate Compact Conformations in the Gas Phase

(2012) Kevin Pagel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Charge-State Dependent Compaction and Dissociation of Protein Complexes: Insights from Ion Mobility and Molecular Dynamics

(2012) Zoe Hall et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Quantification of cardiolipin molecular species inEscherichia colilipid extracts using liquid chromatography/electrospray ionization mass spectrometry

(2012) Teresa A. Garrett et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Bound Anions Differentially Stabilize Multiprotein Complexes in the Absence of Bulk Solvent

(2011) Linjie Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding

(2011) M. Zhou et al.   SCIENCE

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Proteins, Lipids, and Water in the Gas Phase

(2010) David van der Spoel et al.   MACROMOLECULAR BIOSCIENCE

Collision induced unfolding of protein ions in the gas phase studied by ion mobility-mass spectrometry: The effect of ligand binding on conformational stability

(2009) Jonathan T. S. Hopper et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Structural stability of electrosprayed proteins: temperature and hydration effects

(2009) Erik G. Marklund et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Lipids and membrane protein structures

(2008) C HUNTE et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

(2008) David Drew et al.   Nature Protocols

Conformational evolution of ubiquitin ions in electrospray mass spectrometry: molecular dynamics simulations at gradually increasing temperatures

(2008) Elad Segev et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Micelles Protect Membrane Complexes from Solution to Vacuum

(2008) N. P. Barrera et al.   SCIENCE

The enlightening encounter between structure and function in the NhaA Na+–H+ antiporter

(2008) Etana Padan   TRENDS IN BIOCHEMICAL SCIENCES