Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins

NS1 Protein of 2009 Pandemic Influenza A Virus Inhibits Porcine NLRP3 Inflammasome-Mediated Interleukin-1 Beta Production by Suppressing ASC Ubiquitination

(2018) Hong-Su Park et al.   JOURNAL OF VIROLOGY

FUNCTIONAL EVOLUTION OF THE 2009 PANDEMIC H1N1 INFLUENZA NS1 AND PA IN HUMANS

(2018) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses

(2018) Teresa Aydillo et al.   JOURNAL OF VIROLOGY

PA-X: a key regulator of influenza A virus pathogenicity and host immune responses

(2018) Jiao Hu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design

(2018) Yushen Du et al.   SCIENCE

Immunomodulatory Nonstructural Proteins of Influenza A Viruses

(2018) Carolin Klemm et al.   TRENDS IN MICROBIOLOGY

Influenza Virus: Dealing with a Drifting and Shifting Pathogen

(2018) Hyunsuh Kim et al.   VIRAL IMMUNOLOGY

Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast

(2018) Kohei Oishi et al.   VIROLOGY

Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens

(2018) Sascha Trapp et al.   Virology Journal

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

(2018) Marios G. Koliopoulos et al.   Nature Communications

The Discovery of the Antiviral Resistance Gene Mx: A Story of Great Ideas, Great Failures, and Some Success

(2018) Otto Haller et al.   Annual Review of Virology

Host Shutoff in Influenza A Virus: Many Means to an End

(2018) Rachel Levene et al.   Viruses-Basel

The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression

(2017) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR

(2017) Kristina L. Schierhorn et al.   JOURNAL OF VIROLOGY

Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice

(2017) Peter H. Goff et al.   JOURNAL OF VIROLOGY

Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1

(2017) C. Chauché et al.   JOURNAL OF VIROLOGY

Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus

(2017) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses

(2017) Amelia M. Clark et al.   JOURNAL OF VIROLOGY

Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses

(2017) Jinhwa Lee et al.   VIROLOGY

Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines

(2017) Aitor Nogales et al.   VIROLOGY

Host Cell Restriction Factors that Limit Influenza A Infection

(2017) Fernando Villalón-Letelier et al.   Viruses-Basel

Live-Attenuated Influenza Vaccine Effectiveness in Children From 2009 to 2015–2016: A Systematic Review and Meta-Analysis

(2017) Herve Caspard et al.   Open Forum Infectious Diseases

Antigenicity of the 2015–2016 seasonal H1N1 human influenza virus HA and NA proteins

(2017) Amelia M. Clark et al.   PLoS One

Influenza: The Once and Future Pandemic

(2017) Jeffery K. Taubenberger et al.   PUBLIC HEALTH REPORTS

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain

(2017) Christopher S. Anderson et al.   Scientific Reports

G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice

(2016) Challika Kaewborisuth et al.   ARCHIVES OF VIROLOGY

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

(2016) Maria Anastasina et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Standing on three legs: antiviral activities of RIG-I against influenza viruses

(2016) Michaela Weber-Gerlach et al.   CURRENT OPINION IN IMMUNOLOGY

Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection

(2016) Marta L. DeDiego et al.   IMMUNOLOGY

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses

(2016) Marta L. DeDiego et al.   JOURNAL OF VIROLOGY

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

(2016) Miyu Moriyama et al.   JOURNAL OF VIROLOGY

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses

(2016) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity

(2016) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice

(2016) Jiao Hu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

(2016) Jonathan Maelfait et al.   PLoS Pathogens

Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein

(2016) Denys A. Khaperskyy et al.   PLoS Pathogens

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

PA-X is a virulence factor in avian H9N2 influenza virus

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins

(2015) Denys A. Khaperskyy et al.   JOURNAL OF VIROLOGY

Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity

(2015) Kohei Oishi et al.   JOURNAL OF VIROLOGY

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response

(2015) Jiao Hu et al.   JOURNAL OF VIROLOGY

The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

(2015) Laura Bavagnoli et al.   NUCLEIC ACIDS RESEARCH

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection

(2015) Yvonne C. F. Su et al.   Nature Communications

Inhibition of the OAS/RNase L pathway by viruses

(2015) Melissa Drappier et al.   Current Opinion in Virology

Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs

(2015) Irene Ramos et al.   Frontiers in Immunology

Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome

(2015) Woo-Chang Cheong et al.   PLoS One

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses

(2015) Huijie Gao et al.   Scientific Reports

Influenza virus non-structural protein NS1: interferon antagonism and beyond

(2014) D. Marc   JOURNAL OF GENERAL VIROLOGY

Conformational plasticity of the influenza A virus NS1 protein

(2014) B. G. Hale   JOURNAL OF GENERAL VIROLOGY

Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications

(2014) Pascale Hermant et al.   Journal of Innate Immunity

Viral Phosphodiesterases That Antagonize Double-Stranded RNA Signaling to RNase L by Degrading 2-5A

(2014) Robert H. Silverman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Infection and Pathogenesis of Canine, Equine, and Human Influenza Viruses in Canine Tracheas

(2014) G. Gonzalez et al.   JOURNAL OF VIROLOGY

Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine Development

(2014) A. Nogales et al.   JOURNAL OF VIROLOGY

Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host Factor

(2014) K. Tawaratsumida et al.   JOURNAL OF VIROLOGY

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence

(2014) J. Ayllon et al.   JOURNAL OF VIROLOGY

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction

(2014) Firth   Open Biology

IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

(2014) Charles C. Bailey et al.   Annual Review of Virology

Traditional and New Influenza Vaccines

(2013) S.-S. Wong et al.   CLINICAL MICROBIOLOGY REVIEWS

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Emergence of a C-Terminal Seven-Amino-Acid Elongation of NS1 in Around 1950 Conferred a Minor Growth Advantage to Former Seasonal Influenza A Viruses

(2013) F. Lohrmann et al.   JOURNAL OF VIROLOGY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

Phase I/II trial of a replication-deficient trivalent influenza virus vaccine lacking NS1

(2013) Christina Mössler et al.   VACCINE

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

Influenza A virus-encoded NS1 virulence factor protein inhibits innate immune response by targeting IKK

(2012) Shijuan Gao et al.   CELLULAR MICROBIOLOGY

Quadrivalent Ann Arbor strain live-attenuated influenza vaccine

(2012) Seth L Toback et al.   Expert Review of Vaccines

Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

(2012) M. Shi et al.   JOURNAL OF VIROLOGY

NS1-Truncated Live Attenuated Virus Vaccine Provides Robust Protection to Aged Mice from Viral Challenge

(2012) N. Pica et al.   JOURNAL OF VIROLOGY

Suppression of the antiviral response by an influenza histone mimic

(2012) Ivan Marazzi et al.   NATURE

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production

(2011) Eike R. Hrincius et al.   CELLULAR MICROBIOLOGY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

The Virulence of 1997 H5N1 Influenza Viruses in the Mouse Model Is Increased by Correcting a Defect in Their NS1 Proteins

(2011) A. Spesock et al.   JOURNAL OF VIROLOGY

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

Regulation of influenza A virus induced CXCL-10 gene expression requires PI3K/Akt pathway and IRF3 transcription factor

(2011) Xinya Lu et al.   MOLECULAR IMMUNOLOGY

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Effects of the C-Terminal Truncation in NS1 Protein of the 2009 Pandemic H1N1 Influenza Virus on Host Gene Expression

(2011) Jiagang Tu et al.   PLoS One

I B kinase   (IKK ) regulates the balance between type I and type II interferon responses

(2011) S.-L. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influenza virus RNA synthesis machine

(2011) Patricia Resa-Infante et al.   RNA Biology

Induction and function of type I and III interferon in response to viral infection

(2011) David E Levy et al.   Current Opinion in Virology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity

(2010) Oliver Schulz et al.   Cell Host & Microbe

Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus

(2010) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein

(2010) N. C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Glycine 184 in Nonstructural Protein NS1 Determines the Virulence of Influenza A Virus Strain PR8 without Affecting the Host Interferon Response

(2010) S. Steidle et al.   JOURNAL OF VIROLOGY

Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein

(2010) B. G. Hale et al.   JOURNAL OF VIROLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets

(2010) Bin Zhou et al.   VACCINE

Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription

(2010) Rei-Lin Kuo et al.   VIROLOGY

Pre-mRNA 3′-end processing complex assembly and function

(2010) Serena Chan et al.   Wiley Interdisciplinary Reviews-RNA

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

(2009) G. Kochs et al.   JOURNAL OF GENERAL VIROLOGY

Influenza Viruses Control the Vertebrate Type I Interferon System: Factors, Mechanisms, and Consequences

(2009) Thorsten Wolff et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Geographic Dependence, Surveillance, and Origins of the 2009 Influenza A (H1N1) Virus

(2009) Vladimir Trifonov et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

Influenza A viruses with truncated NS1 as modified live virus vaccines: Pilot studies of safety and efficacy in horses

(2008) T. M. Chambers et al.   EQUINE VETERINARY JOURNAL

FluBlok, a recombinant hemagglutinin influenza vaccine

(2008) Manon M.J. Cox et al.   Influenza and Other Respiratory Viruses

Mechanism of Influenza A Virus NS1 Protein Interaction with the p85β, but Not the p85α, Subunit of Phosphatidylinositol 3-Kinase (PI3K) and Up-regulation of PI3K Activity

(2008) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Effectiveness of Inactivated Influenza Vaccines Varied Substantially with Antigenic Match from the 2004–2005 Season to the 2006–2007 Season

(2008) Edward A. Belongia et al.   JOURNAL OF INFECTIOUS DISEASES

Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 Highly Pathogenic Avian Influenza

(2008) J. Steel et al.   JOURNAL OF VIROLOGY

Structural basis for suppression of a host antiviral response by influenza A virus

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

(2008) D. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cold adapted and temperature sensitive influenza A/Ann Arbor/6/60 virus, the master donor virus for live attenuated influenza vaccines, has multiple defects in replication at the restrictive temperature

(2008) Winnie Chan et al.   VIROLOGY