PA-X: a key regulator of influenza A virus pathogenicity and host immune responses

Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast

(2018) Kohei Oishi et al.   VIROLOGY

Human infection with an avian influenza A/H9N2 virus in Guangdong in 2016

(2017) Runyu Yuan et al.   JOURNAL OF INFECTION

Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus

(2017) Aitor Nogales et al.   JOURNAL OF VIROLOGY

Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013–17: an epidemiological study of laboratory-confirmed case series

(2017) Xiling Wang et al.   LANCET INFECTIOUS DISEASES

PA-X protein decreases replication and pathogenicity of swine influenza virus in cultured cells and mouse models

(2017) Xiao-Qian Gong et al.   VETERINARY MICROBIOLOGY

Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses

(2017) Jinhwa Lee et al.   VIROLOGY

PA-X protein contributes to virulence of triple-reassortant H1N2 influenza virus by suppressing early immune responses in swine

(2017) Guanlong Xu et al.   VIROLOGY

Human infections with novel reassortant H5N6 avian influenza viruses in China

(2017) Ye Zhang et al.   Emerging Microbes & Infections

Influenza at the beginning of the 21st century

(2017) Nahoko Shindo et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

(2016) Yuhai Bi et al.   Cell Host & Microbe

Human infection with a novel, highly pathogenic avian influenza A (H5N6) virus: Virological and clinical findings

(2016) Ming Pan et al.   JOURNAL OF INFECTION

Interactomic landscape of PA-X-chicken protein complexes of H5N1 influenza A virus

(2016) Qinghe Li et al.   Journal of Proteomics

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses

(2016) Marta L. DeDiego et al.   JOURNAL OF VIROLOGY

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity

(2016) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice

(2016) Jiao Hu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Comparing the functions of equine and canine influenza H3N8 virus PA-X proteins: Suppression of reporter gene expression and modulation of global host gene expression

(2016) Kurtis H. Feng et al.   VIROLOGY

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization

(2016) Che-Man Chan et al.   VIROLOGY

Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein

(2016) Denys A. Khaperskyy et al.   PLoS Pathogens

Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression

(2016) Deepshikha Kumar et al.   PLoS One

Truncation of C-terminal 20 amino acids in PA-X contributes to adaptation of swine influenza virus in pigs

(2016) Guanlong Xu et al.   Scientific Reports

Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]–APOA1–HBx–Beclin1-mediated autophagic pathway in HBV therapy

(2015) Jin Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

PA-X is a virulence factor in avian H9N2 influenza virus

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

Epidemiology, Evolution, and Recent Outbreaks of Avian Influenza Virus in China

(2015) Shuo Su et al.   JOURNAL OF VIROLOGY

Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins

(2015) Denys A. Khaperskyy et al.   JOURNAL OF VIROLOGY

Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity

(2015) Kohei Oishi et al.   JOURNAL OF VIROLOGY

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response

(2015) Jiao Hu et al.   JOURNAL OF VIROLOGY

The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

(2015) Laura Bavagnoli et al.   NUCLEIC ACIDS RESEARCH

Impact of influenza PA-X on host response

(2015) Tsuyoshi Hayashi et al.   Oncotarget

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses

(2015) Huijie Gao et al.   Scientific Reports

Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice

(2014) C. M. Llompart et al.   JOURNAL OF VIROLOGY

Influenza A Virus Attenuation by Codon Deoptimization of the NS Gene for Vaccine Development

(2014) A. Nogales et al.   JOURNAL OF VIROLOGY

A Single Amino Acid Substitution in the Novel H7N9 Influenza A Virus NS1 Protein Increases CPSF30 Binding and Virulence

(2014) J. Ayllon et al.   JOURNAL OF VIROLOGY

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

(2014) Denys A. Khaperskyy et al.   PLoS Pathogens

Phylogenetics of varied subtypes of avian influenza viruses in China: potential threat to humans

(2014) Weifeng Shi et al.   Protein & Cell

Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China

(2013) Aiping Wu et al.   Cell Host & Microbe

Caspase-1 Deficient Mice Are More Susceptible to Influenza A Virus Infection With PA Variation

(2013) C.-H. Huang et al.   JOURNAL OF INFECTIOUS DISEASES

New Virulence Determinants Contribute to the Enhanced Immune Response and Reduced Virulence of an Influenza A Virus A/PR8/34 Variant

(2013) Swantje Liedmann et al.   JOURNAL OF INFECTIOUS DISEASES

Nucleolin Interacts with the Dengue Virus Capsid Protein and Plays a Role in Formation of Infectious Virus Particles

(2013) C. A. Balinsky et al.   JOURNAL OF VIROLOGY

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Differences in Cytokine Production in Human Macrophages and in Virulence in Mice Are Attributable to the Acidic Polymerase Protein of Highly Pathogenic Influenza A Virus Subtype H5N1

(2012) Saori Sakabe et al.   JOURNAL OF INFECTIOUS DISEASES

Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

(2012) M. Shi et al.   JOURNAL OF VIROLOGY

The PA-Gene-Mediated Lethal Dissemination and Excessive Innate Immune Response Contribute to the High Virulence of H5N1 Avian Influenza Virus in Mice

(2012) J. Hu et al.   JOURNAL OF VIROLOGY

Identification of Novel Influenza A Virus Proteins Translated from PA mRNA

(2012) Y. Muramoto et al.   JOURNAL OF VIROLOGY

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin

(2012) Krister Melén et al.   Virology Journal

Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain

(2012) Helen M. Wise et al.   PLoS Pathogens

Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

(2012) Mohammed Selman et al.   Emerging Microbes & Infections

Overexpression of Thy1/CD90 in human hepatocellular carcinoma is associated with HBV infection and poor prognosis

(2011) Jeng-Wei Lu et al.   ACTA HISTOCHEMICA

MiR-101 regulates HSV-1 replication by targeting ATP5B

(2011) Shu-qi Zheng et al.   ANTIVIRAL RESEARCH

Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor

(2011) Xiaodong Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The influenza virus PB1-F2 protein has interferon-antagonistic activity

(2011) Sabine Eva Dudek et al.   BIOLOGICAL CHEMISTRY

Dimer Interface of the Effector Domain of Non-structural Protein 1 from Influenza A Virus

(2011) James M. Aramini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Infection Induces Acetylation of NPM1 That Facilitates Tat Localization and Enhances Viral Transactivation

(2011) Shrikanth S. Gadad et al.   JOURNAL OF MOLECULAR BIOLOGY

Immunopathogenic and Antibacterial Effects of H3N2 Influenza A Virus PB1-F2 Map to Amino Acid Residues 62, 75, 79, and 82

(2011) I. V. Alymova et al.   JOURNAL OF VIROLOGY

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus

(2011) Farnoosh Tayyari et al.   NATURE MEDICINE

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein

(2011) Ronan Le Goffic et al.   PLoS Pathogens

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

NS1 protein of avian influenza A virus prevents activation of NF-κB through binding to IKKα and IKKβ

(2010) S. Gao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon β Promoter Stimulator 1

(2010) Atsushi Iwai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influenza A Virus Protein PB1-F2 Exacerbates IFN-  Expression of Human Respiratory Epithelial Cells

(2010) R. Le Goffic et al.   JOURNAL OF IMMUNOLOGY

The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon

(2010) K. M. Graef et al.   JOURNAL OF VIROLOGY

Current knowledge on PB1-F2 of influenza A viruses

(2010) Andi Krumbholz et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection

(2010) Takashi Irie et al.   VIROLOGY

Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription

(2010) Rei-Lin Kuo et al.   VIROLOGY

PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology

(2010) Julie L. McAuley et al.   PLoS Pathogens

A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA

(2009) H. M. Wise et al.   JOURNAL OF VIROLOGY

Novel swine-origin influenza A virus in humans: another pandemic knocking at the door

(2009) Martin Michaelis et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells

(2009) Frank T. Vreede et al.   VIROLOGY

Transcription Factor YY1 and Its Associated Acetyltransferases CBP and p300 Interact with Hepatitis Delta Antigens and Modulate Hepatitis Delta Virus RNA Replication

(2008) W.-H. Huang et al.   JOURNAL OF VIROLOGY

Structural basis for suppression of a host antiviral response by influenza A virus

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA