The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity

(2015) Kohei Oishi et al.   JOURNAL OF VIROLOGY

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response

(2015) Jiao Hu et al.   JOURNAL OF VIROLOGY

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses

(2015) Huijie Gao et al.   Scientific Reports

Magnesium-Dependent RNA Binding to the PA Endonuclease Domain of the Avian Influenza Polymerase

(2014) Shiyan Xiao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

An efficient genome sequencing method for equine influenza [H3N8] virus reveals a new polymorphism in the PA-X protein

(2014) Adam Rash et al.   Virology Journal

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

(2013) Kausiki Datta et al.   NUCLEIC ACIDS RESEARCH

Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

(2012) M. Shi et al.   JOURNAL OF VIROLOGY

Identification of Novel Influenza A Virus Proteins Translated from PA mRNA

(2012) Y. Muramoto et al.   JOURNAL OF VIROLOGY

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase

(2012) Erin Noble et al.   VIROLOGY

Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain

(2012) Helen M. Wise et al.   PLoS Pathogens

The 2009 Influenza Pandemic: Promising Lessons For Antiviral Therapy For Future Outbreaks

(2011) L. Bavagnoli et al.   CURRENT MEDICINAL CHEMISTRY

Towards an atomic resolution understanding of the influenza virus replication machinery

(2010) Rob WH Ruigrok et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit

(2010) T. Crepin et al.   JOURNAL OF VIROLOGY

Preferential use of RNA leader sequences during influenza A transcription initiation in vivo

(2010) Christina Geerts-Dimitriadou et al.   VIROLOGY

Base-pairing promotes leader selection to prime in vitro influenza genome transcription

(2010) Christina Geerts-Dimitriadou et al.   VIROLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE