ALS and FTD: an epigenetic perspective

Portraits of TET-mediated DNA hydroxymethylation in cancer

(2016) Jana Jeschke et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells

(2016) Rustam Esanov et al.   EXPERIMENTAL NEUROLOGY

Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms

(2016) Claudia Figueroa-Romero et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Parkinsonism, movement disorders and genetics in frontotemporal dementia

(2016) José Fidel Baizabal-Carvallo et al.   Nature Reviews Neurology

Methylation of C9orf72 expansion reduces RNA foci formation and dipeptide-repeat proteins expression in cells

(2016) Peter O. Bauer   NEUROSCIENCE LETTERS

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

(2016) B. Delatte et al.   SCIENCE

RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian Brain

(2016) Mikaela Behm et al.   TRENDS IN GENETICS

The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients

(2015) Zhengrui Xi et al.   ACTA NEUROPATHOLOGICA

Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72

(2015) Marka van Blitterswijk et al.   ACTA NEUROPATHOLOGICA

Jump from Pre-mutation to Pathologic Expansion in C9orf72

(2015) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

(2015) Max Koppers et al.   ANNALS OF NEUROLOGY

DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics

(2015) Jeremy J. Day et al.   Annual Review of Pharmacology and Toxicology

SnapShot: Genetics of ALS and FTD

(2015) Rita Guerreiro et al.   CELL

Nutriepigenomics

(2015) Marlene Remely et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Bromodomain inhibitors regulate the C9ORF72 locus in ALS

(2015) Zane Zeier et al.   EXPERIMENTAL NEUROLOGY

Role of 5-hydroxymethylcytosine in neurodegeneration

(2015) Shariq I. Sherwani et al.   GENE

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

(2015) Mercedes Prudencio et al.   NATURE NEUROSCIENCE

Mechanisms of stress in the brain

(2015) Bruce S McEwen et al.   NATURE NEUROSCIENCE

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence

(2015) C. T. McMillan et al.   NEUROLOGY

The domain structure and distribution of Alu elements in long noncoding RNAs and mRNAs

(2015) Eugene Z. Kim et al.   RNA

Muscle Expression of SOD1G93A Modulates microRNA and mRNA Transcription Pattern Associated with the Myelination Process in the Spinal Cord of Transgenic Mice

(2015) Gabriella Dobrowolny et al.   Frontiers in Cellular Neuroscience

5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy

(2015) Aparna Vasanthakumar et al.   Cancer Genetics

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage

(2015) Stefania Marcuzzo et al.   Molecular Brain

Whole genome analyses reveal no pathogenetic single nucleotide or structural differences between monozygotic twins discordant for amyotrophic lateral sclerosis

(2015) Karyn Meltz Steinberg et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier

(2014) Jenny Russ et al.   ACTA NEUROPATHOLOGICA

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD

(2014) Elaine Y. Liu et al.   ACTA NEUROPATHOLOGICA

Regulation of Transcription by Long Noncoding RNAs

(2014) Roberto Bonasio et al.   Annual Review of Genetics

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

(2014) Veronique V. Belzil et al.   BRAIN RESEARCH

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

From development to diseases: The role of 5hmC in brain

(2014) Wenjia Sun et al.   GENOMICS

Hypermethylation of the CpG-island near the C9orf72 G4C2-repeat expansion in FTLD patients

(2014) Zhengrui Xi et al.   HUMAN MOLECULAR GENETICS

Increased Expression of MicroRNA-29a in ALS Mice: Functional Analysis of Its Inhibition

(2014) Katie Nolan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MicroRNAs as Potential Circulating Biomarkers for Amyotrophic Lateral Sclerosis

(2014) Frank Cloutier et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA

(2014) Lijuan Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circulating miRNAs as Biomarkers for Neurodegenerative Disorders

(2014) Margherita Grasso et al.   MOLECULES

Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia

(2014) Eduardo Gascon et al.   NATURE MEDICINE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

Mobile DNA elements in the generation of diversity and complexity in the brain

(2014) Jennifer A. Erwin et al.   NATURE REVIEWS NEUROSCIENCE

Identical twins with the C9orf72 repeat expansion are discordant for ALS

(2014) Z. Xi et al.   NEUROLOGY

Neuroepigenetics of stress

(2014) B.B. Griffiths et al.   NEUROSCIENCE

MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis

(2014) Janne M. Toivonen et al.   PLoS One

Stress and the dynamic genome: Steroids, epigenetics, and the transposome: Fig. 1.

(2014) Richard G. Hunter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs

(2014) R. Johnson et al.   RNA

Connections between TET proteins and aberrant DNA modification in cancer

(2014) Yun Huang et al.   TRENDS IN GENETICS

Biological and biochemical modulation of DNA methylation

(2014) Raymond Lo et al.   Epigenomics

An Epigenetic Signature in Peripheral Blood Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy

(2014) Yun Li et al.   PLoS Genetics

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

(2014) Sahar Al-Mahdawi et al.   Frontiers in Neuroscience

Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia

(2013) Pietro Fratta et al.   ACTA NEUROPATHOLOGICA

Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood

(2013) Veronique V. Belzil et al.   ACTA NEUROPATHOLOGICA

Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

(2013) Sandra Almeida et al.   ACTA NEUROPATHOLOGICA

Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion

(2013) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: A population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis

(2013) Susan Byrne et al.   ANNALS OF NEUROLOGY

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

(2013) Veronica J Peschansky et al.   Epigenetics

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

(2013) Erica D. Koval et al.   HUMAN MOLECULAR GENETICS

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

(2013) M. T. Reilly et al.   JOURNAL OF NEUROSCIENCE

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

(2013) Michael T. Y. Lam et al.   NATURE

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD

(2013) Naoki Suzuki et al.   NATURE NEUROSCIENCE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Novel causal genes and disease modifiers

(2013) Rosa Rademakers et al.   Nature Reviews Neurology

Familial clustering of ALS in a population-based resource

(2013) S. B. Gibson et al.   NEUROLOGY

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Epigenetics of Alzheimer’s Disease and Frontotemporal Dementia

(2013) Chendhore S. Veerappan et al.   Neurotherapeutics

Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?

(2013) Ian F. Harrison et al.   PHARMACOLOGY & THERAPEUTICS

Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations

(2013) Zhijun Zhang et al.   PLoS One

Deletion of C9ORF72 Results in Motor Neuron Degeneration and Stress Sensitivity in C. elegans

(2013) Martine Therrien et al.   PLoS One

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

(2013) K. Mori et al.   SCIENCE

Frontotemporal Dementia

(2013) Bruce Miller et al.   SEMINARS IN NEUROLOGY

Stress and anxiety across the lifespan: structural plasticity and epigenetic regulation

(2013) Richard G Hunter et al.   Epigenomics

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

(2013) Lucio Tremolizzo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Promoter DNA methylation regulates progranulin expression and is altered in FTLD

(2013) Julia Banzhaf-Strathmann et al.   Acta Neuropathologica Communications

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Familial frontotemporal dementia and amyotrophic lateral sclerosis associated with the C9ORF72 hexanucleotide repeat

(2012) J. Hodges   BRAIN

Misregulated RNA processing in amyotrophic lateral sclerosis

(2012) Magdalini Polymenidou et al.   BRAIN RESEARCH

Frontotemporal Lobar Degeneration

(2012) Rachel E. Seltman et al.   CNS DRUGS

How do C9ORF72 repeat expansions cause amyotrophic lateral sclerosis and frontotemporal dementia

(2012) Marka van Blitterswijk et al.   CURRENT OPINION IN NEUROLOGY

Delivering the promise of miRNA cancer therapeutics

(2012) Diane M. Pereira et al.   DRUG DISCOVERY TODAY

The Emerging Science of BMAA: Do Cyanobacteria Contribute to Neurodegenerative Disease?

(2012) Wendee Holtcamp   ENVIRONMENTAL HEALTH PERSPECTIVES

Understanding ALS: new therapeutic approaches

(2012) Antonio Musarò   FEBS Journal

Metal-Sulfate Induced Generation of ROS in Human Brain Cells: Detection Using an Isomeric Mixture of 5- and 6-Carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a Cell Permeant Tracer

(2012) Aileen I. Pogue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

(2012) Elisa Majounie et al.   LANCET NEUROLOGY

RNA-mediated toxicity in neurodegenerative disease

(2012) Veronique V. Belzil et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration

(2012) Daniela Galimberti et al.   NEUROLOGICAL SCIENCES

Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

(2012) S. Seisenberger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

The range and clinical impact of cognitive impairment in French patients with ALS: A cross-sectional study of neuropsychological test performance

(2011) Paul H. Gordon et al.   Amyotrophic Lateral Sclerosis

Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period

(2011) Oskar Karlsson et al.   BEHAVIOURAL BRAIN RESEARCH

Motor Neuron dysfunction in frontotemporal dementia

(2011) James R. Burrell et al.   BRAIN

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study

(2011) Ilse Gijselinck et al.   LANCET NEUROLOGY

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

PIWI-interacting small RNAs: the vanguard of genome defence

(2011) Mikiko C. Siomi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Does α-Amino-β-methylaminopropionic Acid (BMAA) Play a Role in Neurodegeneration?

(2011) Alexander S. Chiu et al.   International Journal of Environmental Research and Public Health

The cognitive profile of amyotrophic lateral sclerosis: A meta-analysis

(2010) Joost Raaphorst et al.   Amyotrophic Lateral Sclerosis

The Promise of MicroRNA Replacement Therapy

(2010) A. G. Bader et al.   CANCER RESEARCH

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) S. Byrne et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study

(2010) Hannu Laaksovirta et al.   LANCET NEUROLOGY

Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review

(2010) Maria Teresa Giordana et al.   NEUROLOGICAL SCIENCES

MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia

(2010) Jian Jiao et al.   PLoS One

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels

(2010) Maja Klug et al.   GENOME BIOLOGY

A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis

(2009) Julia M. Morahan et al.   Amyotrophic Lateral Sclerosis

A cluster of amyotrophic lateral sclerosis in New Hampshire: A possible role for toxic cyanobacteria blooms

(2009) Tracie A. Caller et al.   Amyotrophic Lateral Sclerosis

Beyond Guam: The cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases

(2009) Walter G. Bradley et al.   Amyotrophic Lateral Sclerosis

Effects of the cyanobacterial neurotoxin β-N-methylamino-L-alanine on the early-life stage development of zebrafish (Danio rerio)

(2009) E.L. Purdie et al.   AQUATIC TOXICOLOGY

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

(2009) N. Finch et al.   BRAIN

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

(2009) Adriano Chiò et al.   HUMAN MOLECULAR GENETICS

Interaction between PON1 and population density in amyotrophic lateral sclerosis

(2009) Frank P. Diekstra et al.   NEUROREPORT

The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis

(2009) Frank O. Johnson et al.   NEUROTOXICOLOGY

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

RNAs as extracellular signaling molecules

(2008) Marcel E Dinger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Noncoding RNA in development

(2008) Paulo P. Amaral et al.   MAMMALIAN GENOME

Human Alu RNA Is a Modular Transacting Repressor of mRNA Transcription during Heat Shock

(2008) Peter D. Mariner et al.   MOLECULAR CELL

Environmental-induced oxidative stress in neurodegenerative disorders and aging

(2008) Lucia Migliore et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Antisense transcripts are targets for activating small RNAs

(2008) Jacob C Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyotrophic Lateral Sclerosis among 1991 Gulf War Veterans: Evidence for a Time-Limited Outbreak

(2008) Ronnie D. Horner et al.   NEUROEPIDEMIOLOGY

Incidence of early-onset dementias in Cambridgeshire, United Kingdom

(2008) L. Mercy et al.   NEUROLOGY

Association of paraoxonase gene cluster polymorphisms with ALS in France, Quebec, and Sweden

(2008) P. N. Valdmanis et al.   NEUROLOGY

Spatial analysis of the etiology of amyotrophic lateral sclerosis among 1991 Gulf War veterans

(2008) Marie Lynn Miranda et al.   NEUROTOXICOLOGY

The Eukaryotic Genome as an RNA Machine

(2008) P. P. Amaral et al.   SCIENCE

Lifting the veil on the transcriptome

(2008) Kevin P Callahan et al.   GENOME BIOLOGY