The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

5-Hydroxymethylcytosine: A new player in brain disorders?

(2015) Ying Cheng et al.   EXPERIMENTAL NEUROLOGY

oxBS-450K: A method for analysing hydroxymethylation using 450K BeadChips

(2015) Sabrina K. Stewart et al.   METHODS

Do Epigenetic Pathways Initiate Late Onset Alzheimer Disease (LOAD): Towards a New Paradigm

(2014) Syed Waseem Bihaqi et al.   Current Alzheimer Research

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells

(2014) C. Jin et al.   NUCLEIC ACIDS RESEARCH

Amyotrophic Lateral Sclerosis: A Focus on Disease Progression

(2014) Ana C. Calvo et al.   Biomed Research International

Epigenetic-based therapies for Friedreich ataxia

(2014) Chiranjeevi Sandi et al.   Frontiers in Genetics

Diversity of two forms of DNA methylation in the brain

(2014) Yuanyuan Chen et al.   Frontiers in Genetics

Fragile X syndrome: From protein function to therapy

(2013) Claudia Bagni et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease

(2013) Michael Haffner et al.   CELL CYCLE

Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome

(2013) Bing Yao et al.   HUMAN MOLECULAR GENETICS

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

(2013) Fengli Wang et al.   HUMAN MOLECULAR GENETICS

Nikolaus Friedreich and degenerative atrophy of the dorsal columns of the spinal cord

(2013) Arnulf H. Koeppen   JOURNAL OF NEUROCHEMISTRY

Diabetes in Friedreich Ataxia

(2013) Miriam Cnop et al.   JOURNAL OF NEUROCHEMISTRY

Cardiomyopathy of Friedreich Ataxia

(2013) Frank Weidemann et al.   JOURNAL OF NEUROCHEMISTRY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool

(2013) Vito Iacobazzi et al.   MOLECULAR GENETICS AND METABOLISM

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Role of Tet1 in erasure of genomic imprinting

(2013) Shinpei Yamaguchi et al.   NATURE

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease

(2013) Izaskun Villar-Menéndez et al.   NEUROMOLECULAR MEDICINE

Friedreich Ataxia Patient Tissues Exhibit Increased 5-Hydroxymethylcytosine Modification and Decreased CTCF Binding at the FXN Locus

(2013) Sahar Al-Mahdawi et al.   PLoS One

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic modifications in trinucleotide repeat diseases

(2013) Marguerite V. Evans-Galea et al.   TRENDS IN MOLECULAR MEDICINE

5-hydroxymethylcytosine and its potential roles in development and cancer

(2013) Gerd P Pfeifer et al.   Epigenetics & Chromatin

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

DNA methylation, a hand behind neurodegenerative diseases

(2013) Haoyang Lu et al.   Frontiers in Aging Neuroscience

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum

(2012) Tao Wang et al.   HUMAN MOLECULAR GENETICS

The Mammaliande NovoDNA Methyltransferases DNMT3A and DNMT3B Are Also DNA 5-Hydroxymethylcytosine Dehydroxymethylases

(2012) Chun-Chang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

(2012) Toshinobu Nakamura et al.   NATURE

Tet1 controls meiosis by regulating meiotic gene expression

(2012) Shinpei Yamaguchi et al.   NATURE

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

(2012) Tarang Khare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

(2012) Eun-Ang Raiber et al.   GENOME BIOLOGY

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

(2012) J S Rao et al.   Translational Psychiatry

FXN methylation predicts expression and clinical outcome in Friedreich ataxia

(2011) Marguerite V. Evans-Galea et al.   ANNALS OF NEUROLOGY

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

(2011) Salvatore Cortellino et al.   CELL

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells

(2011) Ozlem Yildirim et al.   CELL

Epigenetics in Alzheimers Disease: a Focus on DNA Modifications

(2011) Natacha Coppieters et al.   CURRENT PHARMACEUTICAL DESIGN

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

(2011) Atanu Maiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine

(2011) Chun-Xiao Song et al.   NATURE METHODS

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Uncovering the role of 5-hydroxymethylcytosine in the epigenome

(2011) Miguel R. Branco et al.   NATURE REVIEWS GENETICS

Amyotrophic Lateral Sclerosis: What Role Does Environment Play?

(2011) Aiesha Ahmed et al.   NEUROLOGIC CLINICS

Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

(2011) Carina Frauer et al.   PLoS One

Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos

(2011) A. Inoue et al.   SCIENCE

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Integrating 5-Hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells

(2011) Keith E. Szulwach et al.   PLoS Genetics

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

(2011) Hume Stroud et al.   GENOME BIOLOGY

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

A Distinct DNA-Methylation Boundary in the 5′- Upstream Sequence of the FMR1 Promoter Binds Nuclear Proteins and Is Lost in Fragile X Syndrome

(2009) Anja Naumann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ectopic expression of CGG containing mRNA is neurotoxic in mammals

(2009) V. Hashem et al.   HUMAN MOLECULAR GENETICS

DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain

(2009) Marta Barrachina et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Molecular basis of Parkinsonʼs disease

(2009) Yan Xiang Yang et al.   NEUROREPORT

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One