Circulating miRNAs as Biomarkers for Neurodegenerative Disorders

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

MicroRNA Signatures in Neurological Disorders

(2014) Gowhar Shafi et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma

(2014) Shephali Bhatnagar et al.   Frontiers in Molecular Neuroscience

MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma

(2013) Lynn M. Bekris et al.   BIOMARKERS

Recent developments in biomarkers in Parkinson disease

(2013) Anthony H.V. Schapira   CURRENT OPINION IN NEUROLOGY

Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation

(2013) J. Hausser et al.   GENOME RESEARCH

Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls

(2013) Lucía F. Cardo et al.   JOURNAL OF NEUROLOGY

Ushering in the study and treatment of preclinical Alzheimer disease

(2013) Jessica B. Langbaum et al.   Nature Reviews Neurology

Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

(2013) C. Sala Frigerio et al.   NEUROLOGY

Loop-miRs: active microRNAs generated from single-stranded loop regions

(2013) Julia Winter et al.   NUCLEIC ACIDS RESEARCH

Circulating miRNA Biomarkers for Alzheimer's Disease

(2013) Pavan Kumar et al.   PLoS One

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

(2013) Emily F. Goodall et al.   Frontiers in Cellular Neuroscience

A blood based 12-miRNA signature of Alzheimer disease patients

(2013) Petra Leidinger et al.   GENOME BIOLOGY

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes

(2013) Lilach Soreq et al.   Frontiers in Molecular Neuroscience

A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis

(2012) Bruna De Felice et al.   GENE

Circulating microRNAs in plasma as early detection markers for breast cancer

(2012) Katarina Cuk et al.   INTERNATIONAL JOURNAL OF CANCER

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Spreading of Alzheimer’s disease inflammatory signaling through soluble micro-RNA

(2012) Walter J. Lukiw et al.   NEUROREPORT

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cleavage of ST6Gal I by Radiation-Induced BACE1 Inhibits Golgi-Anchored ST6Gal I-Mediated Sialylation of Integrin β1 and Migration in Colon Cancer Cells

(2012) Minyoung Lee et al.   Radiation Oncology

Genetics and Epigenetics of Parkinson's Disease

(2012) Fabio Coppedè   TheScientificWorldJOURNAL

Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

(2011) Hirosha Geekiyanage et al.   EXPERIMENTAL NEUROLOGY

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

(2011) Elena Miñones-Moyano et al.   HUMAN MOLECULAR GENETICS

Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease

(2011) Philip Michael Gaughwin et al.   HUMAN MOLECULAR GENETICS

Identification of blood microRNAs associated to Parkinsońs disease

(2011) Regina Margis et al.   JOURNAL OF BIOTECHNOLOGY

MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid  , Novel Targets in Sporadic Alzheimer's Disease

(2011) H. Geekiyanage et al.   JOURNAL OF NEUROSCIENCE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Toward the blood-borne miRNome of human diseases

(2011) Andreas Keller et al.   NATURE METHODS

Identification of Muscle-Specific MicroRNAs in Serum of Muscular Dystrophy Animal Models: Promising Novel Blood-Based Markers for Muscular Dystrophy

(2011) Hideya Mizuno et al.   PLoS One

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

(2011) Madalena Martins et al.   PLoS One

Cancer and neurodegenerative disorders: pathogenic convergence through microRNA regulation

(2011) L. Du et al.   Journal of Molecular Cell Biology

MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

(2010) Justin M. Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease

(2010) Zhen Hong et al.   BRAIN

miR-133b regulates the MET proto-oncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo

(2010) Gui Hu et al.   CANCER BIOLOGY & THERAPY

Tumor Invasion and Metastasis Initiated by mir-106b in Breast Cancer by Targeting BRMS1 and RB.

(2010) S. Pan et al.   CANCER RESEARCH

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma

(2010) Masayuki Kano et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers

(2010) Ke Zen et al.   MEDICINAL RESEARCH REVIEWS

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3

(2010) M. Shioya et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

miRBase: integrating microRNA annotation and deep-sequencing data

(2010) A. Kozomara et al.   NUCLEIC ACIDS RESEARCH

Genetic determinants at the interface of cancer and neurodegenerative disease

(2010) L G T Morris et al.   ONCOGENE

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer

(2009) Melissa Crawford et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

(2009) R. Garzon et al.   BLOOD

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Abundant conserved microRNA target sites in the 5′-untranslated region and coding sequence

(2009) Xue Zhou et al.   GENETICA

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

(2009) I. Lee et al.   GENOME RESEARCH

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

(2008) Filip Simunovic et al.   BRAIN

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

(2008) Charles H. Lawrie et al.   BRITISH JOURNAL OF HAEMATOLOGY

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans

(2008) Ryusuke Niwa et al.   DEVELOPMENTAL BIOLOGY

Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract

(2008) Y. Arvidsson et al.   ENDOCRINE-RELATED CANCER

Protein biomarkers for amyotrophic lateral sclerosis

(2008) Henrik Ryberg et al.   Expert Review of Proteomics

Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis

(2008) Kerstin Krause et al.   JOURNAL OF ENDOCRINOLOGY

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of  -Site Amyloid Precursor Protein-Cleaving Enzyme 1

(2008) W.-X. Wang et al.   JOURNAL OF NEUROSCIENCE

Biomarkers in amyotrophic lateral sclerosis

(2008) Martin R Turner et al.   LANCET NEUROLOGY

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

(2008) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

(2008) Sébastien S. Hébert et al.   NEUROBIOLOGY OF DISEASE

Biomarkers of Alzheimer's disease

(2008) Rebecca Craig-Schapiro et al.   NEUROBIOLOGY OF DISEASE

Serum MicroRNAs Are Promising Novel Biomarkers

(2008) Shlomit Gilad et al.   PLoS One

Detection of microRNA Expression in Human Peripheral Blood Microvesicles

(2008) Melissa Piper Hunter et al.   PLoS One

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA