The Role of ARX in Human Pancreatic Endocrine Specification

Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing  -cells to a  -like fate and reveals a facultative proliferative capacity in aged  -cells

(2015) F. C. Pan et al.   DEVELOPMENT

Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions

(2014) David E. Metzger et al.   DIABETES

The diabetes gene Hhex maintains  -cell differentiation and islet function

(2014) J. Zhang et al.   GENES & DEVELOPMENT

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Overexpression of PAX4 reduces glucagon expression in differentiating hESCs

(2014) Blair K Gage et al.   Islets

A human embryonic stem cell line adapted for high throughput screening

(2013) Nicolas J. Caron et al.   BIOTECHNOLOGY AND BIOENGINEERING

Initial Cell Seeding Density Influences Pancreatic Endocrine Development During in vitro Differentiation of Human Embryonic Stem Cells

(2013) Blair K. Gage et al.   PLoS One

Arx Polyalanine Expansion in Mice Leads to Reduced Pancreatic α-Cell Specification and Increased α-Cell Death

(2013) Crystal L. Wilcox et al.   PLoS One

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Arx is required for normal enteroendocrine cell development in mice and humans

(2012) Aiping Du et al.   DEVELOPMENTAL BIOLOGY

Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations

(2012) Ginam Cho et al.   NEUROGENETICS

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression

(2011) Teresa L. Mastracci et al.   DEVELOPMENTAL BIOLOGY

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut

(2010) Yukihiro Fujita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation

(2010) Masayuki Itoh et al.   DIFFERENTIATION

ARX spectrum disorders: making inroads into the molecular pathology

(2010) Cheryl Shoubridge et al.   HUMAN MUTATION

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Analysis of the hypothalamus in a case of X-linked lissencephaly with abnormal genitalia (XLAG)

(2008) Rie Miyata et al.   BRAIN & DEVELOPMENT

Transcription factor expression in the developing human fetal endocrine pancreas

(2008) B. M. Lyttle et al.   DIABETOLOGIA

PAX4 Enhances Beta-Cell Differentiation of Human Embryonic Stem Cells

(2008) Chee Gee Liew et al.   PLoS One

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

(2008) Carola Engler et al.   PLoS One