Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

Life and death of proteins after protease cleavage: protein degradation by the N-end rule pathway

(2017) Nico Dissmeyer et al.   NEW PHYTOLOGIST

Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway

(2017) Jang-Hyun Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

(2017) Shun-Jia Chen et al.   SCIENCE

Comprehensive analysis of human protein N-termini enables assessment of various protein forms

(2017) Jeonghun Yeom et al.   Scientific Reports

Multiple E3s promote the degradation of histone H3 variant Cse4

(2017) Haili Cheng et al.   Scientific Reports

The Ubiquitin Ligase (E3) Psh1p Is Required for Proper Segregation of Both Centromeric and Two Micron Plasmids in Saccharomyces cerevisiae

(2017) Meredith B. Metzger et al.   G3-Genes Genomes Genetics

Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

(2016) Philip J. Robinson et al.   CELL

Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays

(2016) Brandon Wadas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway

(2016) Min Kyung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First Things First: Vital Protein Marks by N-Terminal Acetyltransferases

(2016) Henriette Aksnes et al.   TRENDS IN BIOCHEMICAL SCIENCES

N-terminal protein modifications: Bringing back into play the ribosome

(2015) Carmela Giglione et al.   BIOCHIMIE

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

(2015) S.-E. Park et al.   SCIENCE

Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates

(2014) Izarys Rivera-Rivera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions

(2014) Daniel J. Gibbs et al.   TRENDS IN CELL BIOLOGY

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

(2013) Heon-Ki Kim et al.   CELL

A Novel Role of the N Terminus of Budding Yeast Histone H3 Variant Cse4 in Ubiquitin-Mediated Proteolysis

(2013) W. C. Au et al.   GENETICS

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

(2012) K. I. Piatkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4

(2010) Geetha Hewawasam et al.   MOLECULAR CELL

An E3 Ubiquitin Ligase Prevents Ectopic Localization of the Centromeric Histone H3 Variant via the Centromere Targeting Domain

(2010) Prerana Ranjitkar et al.   MOLECULAR CELL

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

(2010) Woo Suk Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of substrate recognition and specificity in the N-end rule pathway

(2010) Edna Matta-Camacho et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

ClpS is the recognition component forEscherichia colisubstrates of the N-end rule degradation pathway

(2009) Ronny Schmidt et al.   MOLECULAR MICROBIOLOGY

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

(2008) Rouven Bingel-Erlenmeyer et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY