Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

Macrophage Deletion of p38  Partially Impairs Lipopolysaccharide-Induced Cellular Activation

(2014) Y. J. Kang et al.   JOURNAL OF IMMUNOLOGY

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

(2011) R. Noubade et al.   BLOOD

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation

(2011) L. Jirmanova et al.   BLOOD

Signaling by the Phosphatase MKP-1 in Dendritic Cells Imprints Distinct Effector and Regulatory T Cell Fates

(2011) Gonghua Huang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

Interferon-β exacerbates Th17-mediated inflammatory disease

(2011) Robert C. Axtell et al.   TRENDS IN IMMUNOLOGY

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

(2010) Muhammet F. Gulen et al.   IMMUNITY

IL-1 -Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-Producing Cells

(2010) L. Li et al.   JOURNAL OF IMMUNOLOGY

Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

(2010) L. Lu et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

(2010) Xuebin Liu et al.   NATURE MEDICINE

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-  limits IL-17-mediated autoimmune inflammation

(2010) G. Murugaiyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicans

(2009) Frank L. van de Veerdonk et al.   Cell Host & Microbe

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination

(2009) Gonghua Huang et al.   CYTOKINE

A Pivotal Role for CD40-Mediated IL-6 Production by Dendritic Cells during IL-17 Induction In Vivo

(2009) G. Perona-Wright et al.   JOURNAL OF IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

CD40–CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells

(2009) Giandomenica Iezzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin

(2008) Mari L. Shinohara et al.   IMMUNITY

Distinctin vivoroles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis

(2008) Dragana Odobasic et al.   IMMUNOLOGY

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction

(2008) Jay C. Sy et al.   NATURE MATERIALS