Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells

Functions of the Lyn tyrosine kinase in health and disease

(2012) Evan Ingley   Cell Communication and Signaling

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Lyn-Dependent Signaling Regulates the Innate Immune Response by Controlling Dendritic Cell Activation of NK Cells

(2012) D. L. Krebs et al.   JOURNAL OF IMMUNOLOGY

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation

(2012) David A Hill et al.   NATURE MEDICINE

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

(2012) Janelle S Ayres et al.   NATURE MEDICINE

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Lymphoid microenvironments and innate lymphoid cells in the gut

(2012) Claire Pearson et al.   TRENDS IN IMMUNOLOGY

Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen Challenge

(2011) Alexei V. Tumanov et al.   Cell Host & Microbe

Predicting Ulcerative Colitis-Associated Colorectal Cancer Using Reverse-Transcription Polymerase Chain Reaction Analysis

(2011) Toshiaki Watanabe et al.   Clinical Colorectal Cancer

TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation

(2011) Trine Olsen et al.   CYTOKINE

IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality

(2011) Laure Dumoutier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

Development and evolution of RORγt+ cells in a microbe’s world

(2011) Gérard Eberl   IMMUNOLOGICAL REVIEWS

Recent advances in IL-22 biology

(2011) L. A. Zenewicz et al.   INTERNATIONAL IMMUNOLOGY

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

The Src Family of Protein Tyrosine Kinases: A New and Promising Target for Colorectal Cancer Therapy

(2010) Christopher Lieu et al.   Clinical Colorectal Cancer

Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

(2010) Tetsuro Takayama et al.   GASTROENTEROLOGY

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

(2010) Gregory F. Sonnenberg et al.   IMMUNITY

An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer: Figure 1.

(2010) Mark Asquith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of Murine Macrophages via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1

(2010) S. Keck et al.   JOURNAL OF IMMUNOLOGY

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

(2010) L. Van Maele et al.   JOURNAL OF IMMUNOLOGY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy

(2009) S Mustjoki et al.   LEUKEMIA

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer

(2009) Linda A. Feagins et al.   Nature Reviews Gastroenterology & Hepatology

SEVERE HEMORRHAGIC COLITIS CAUSED BY DASATINIB IN PHILADELPHIA CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

(2009) Tomoyuki Shimokaze et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES