Journal
AUTOIMMUNITY REVIEWS
Volume 13, Issue 6, Pages 615-620Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2013.11.008
Keywords
T-helper cell; Innate immunity; Interleukin-22; Cytokine receptor; Signal pathway; Autoimmunity
Categories
Funding
- NIH [AR-059103, AI-084359]
- Rheumatology Research Foundation of the American College of Rheumatology
- Science Foundation of Science and Technology Department of Zhejiang Province [20070305]
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Interleukin-22 (IL-22) is a member of IL-10 family cytoldnes that is produced by many different types of lymphocytes including both those of the innate and adaptive immune systems. This includes activated T cells, most notably Th17 and Th22 cells, and NI( cells,gamma delta T cells, LTi cells and LTi-like cells. IL-22 mediates its effects via the IL-22-1L22R complex and subsequent Janus kinase-signal transducer and activators of transcription (JAK-STAT) signaling pathway. Recently accumulated evidence has indicated that IL-22 also plays an important role in the pathogenesis of many autoimmune diseases. In this review, we discuss the recent findings and advancement of the role for IL-22 in several autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), hepatitis, graft versus host disease (GHVD) and allergic diseases, implicating that target IL-22 may have a therapeutic potential in those autoimmune diseases. (C) 2014 Elsevier B.V. All rights reserved.
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