Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters

The participation of fibroblast growth factor 23 (FGF23) in the progression of osteoporosis via JAK/STAT pathway

(2018) Lijun Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2

(2018) Nina Bon et al.   Molecular Metabolism

FGF23 Actions on Target Tissues—With and Without Klotho

(2018) Beatrice Richter et al.   Frontiers in Endocrinology

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

(2018) Gaozhi Chen et al.   NATURE

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

(2018) Sangwon Lee et al.   NATURE

Klotho expression in long bones regulates FGF23 production during renal failure

(2017) Jovana Kaludjerovic et al.   FASEB JOURNAL

Klotho expression in osteocytes regulates bone metabolism and controls bone formation

(2017) Hirotaka Komaba et al.   KIDNEY INTERNATIONAL

PAI-1 is a critical regulator of FGF23 homeostasis

(2017) Mesut Eren et al.   Science Advances

Conditional Deletion of MurineFgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia

(2016) Erica L Clinkenbeard et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Recent Trends in Cardiovascular Mortality in the United States and Public Health Goals

(2016) Stephen Sidney et al.   JAMA Cardiology

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

(2015) Alexander Grabner et al.   Cell Metabolism

Secreted klotho protein attenuates osteogenic differentiation of human bone marrow mesenchymal stem cellsin vitrovia inactivation of the FGFR1/ERK signaling pathway

(2015) Wei Zhang et al.   GROWTH FACTORS

Intestinal Depletion of NaPi-IIb/Slc34 a2 in Mice: Renal and Hormonal Adaptation

(2015) Nati Hernando et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Renal Production, Uptake, and Handling of Circulating  Klotho

(2015) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bone mineralization is regulated by signaling cross talk between molecular factors of local and systemic origin: The role of fibroblast growth factor 23

(2014) Rony Sapir-Koren et al.   BIOFACTORS

Renal osteodystrophy in children

(2014) Markus J. Kemper et al.   CURRENT OPINION IN PEDIATRICS

α-Klotho mice demonstrate increased expression of the non-sulfated N-glycan form of the HNK-1 glyco-epitope in kidney tissue

(2014) Keiko Akasaka-Manya et al.   JOURNAL OF BIOCHEMISTRY

Klotho Up-regulates Renal Calcium Channel Transient Receptor Potential Vanilloid 5 (TRPV5) by Intra- and ExtracellularN-glycosylation-dependent Mechanisms

(2014) Matthias T. F. Wolf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of serum phosphate

(2014) Eleanor Lederer   JOURNAL OF PHYSIOLOGY-LONDON

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

(2014) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast growth factor 23 and acute kidney injury

(2014) Javier A. Neyra et al.   PEDIATRIC NEPHROLOGY

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

(2014) V. S. Tagliabracci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

(2013) Ming Chang Hu et al.   Annual Review of Physiology

Phosphate Transporters and Their Function

(2013) Jürg Biber et al.   Annual Review of Physiology

Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia

(2013) Jian Q. Feng et al.   BONE

The Epithelial Calcium Channel TRPV5 Is Regulated Differentially by Klotho and Sialidase

(2013) Elizabeth H. P. Leunissen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lower Fibroblast Growth Factor 23 Levels in Young Adults With Crohn Disease as a Possible Secondary Compensatory Effect on the Disturbance of Bone and Mineral Metabolism

(2013) Konstantinos A. Oikonomou et al.   JOURNAL OF CLINICAL DENSITOMETRY

Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice

(2013) Jakob Voelkl et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention

(2013) Ron T Gansevoort et al.   LANCET

Phosphate transporters of the SLC20 and SLC34 families

(2013) Ian C. Forster et al.   MOLECULAR ASPECTS OF MEDICINE

Fibroblast growth factor 23 enhances renal klotho abundance

(2013) Tsuneo Takenaka et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The SLC34 family of sodium-dependent phosphate transporters

(2013) Carsten A. Wagner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway

(2012) Olena Andrukhova et al.   BONE

Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease

(2012) L. Darryl Quarles   EXPERIMENTAL CELL RESEARCH

Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

(2012) Wei Ling Lau et al.   KIDNEY INTERNATIONAL

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

(2012) L. Darryl Quarles   Nature Reviews Endocrinology

Genetic disorders of phosphate regulation

(2012) Jyothsna Gattineni et al.   PEDIATRIC NEPHROLOGY

FGF23 production by osteocytes

(2012) Lynda F. Bonewald et al.   PEDIATRIC NEPHROLOGY

Intestinal Phosphate Transport

(2011) Yves Sabbagh et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Role of Klotho in Aging, Phosphate Metabolism, and CKD

(2011) George B. John et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Fibroblast Growth Factor 23 (FGF23) and Alpha-Klotho Stimulate Osteoblastic MC3T3.E1 Cell Proliferation and Inhibit Mineralization

(2011) V. Shalhoub et al.   CALCIFIED TISSUE INTERNATIONAL

Downregulation of NaPi-IIa and NaPi-IIb Na+-coupled Phosphate Transporters by Coexpression of Klotho

(2011) Miribane Dërmaku-Sopjani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reciprocal Control of 1,25-Dihydroxyvitamin D and FGF23 Formation Involving the FGF23/Klotho System

(2010) D. Prie et al.   Clinical Journal of the American Society of Nephrology

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

The Regulation of Parathyroid Hormone Secretion and Synthesis

(2010) R. Kumar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast growth factor 23 and bone metabolism in children with chronic kidney disease

(2010) Michael van Husen et al.   KIDNEY INTERNATIONAL

Phosphate Levels and Cardiovascular Disease in the General Population

(2009) R. N. Foley   Clinical Journal of the American Society of Nephrology

Do osteocytes contribute to phosphate homeostasis?

(2009) Jian Q Feng et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Ablation of theGalnt3Gene Leads to Low-Circulating Intact Fibroblast Growth Factor 23 (Fgf23) Concentrations and Hyperphosphatemia Despite IncreasedFgf23Expression

(2009) Shoji Ichikawa et al.   ENDOCRINOLOGY

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

(2009) Teruyo Nakatani et al.   FASEB JOURNAL

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Effects of hPTH(1-34) Infusion on Circulating Serum Phosphate, 1,25-Dihydroxyvitamin D, and FGF23 Levels in Healthy Men

(2009) Sherri-Ann M Burnett-Bowie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Intestinal Npt2b Plays a Major Role in Phosphate Absorption and Homeostasis

(2009) Y. Sabbagh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Renal Outer Medullary Potassium Channel and Renal K+ Excretion by Klotho

(2009) S.-K. Cha et al.   MOLECULAR PHARMACOLOGY

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

(2008) Teruyo Nakatani et al.   FASEB JOURNAL

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

(2008) S.-K. Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA