Bone mineralization is regulated by signaling cross talk between molecular factors of local and systemic origin: The role of fibroblast growth factor 23

Hypophosphatemic osteomalacia and bone sclerosis caused by a novel homozygous mutation of the FAM20C gene in an elderly man with a mild variant of Raine syndrome

(2014) Shinji Takeyari et al.   BONE

Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia

(2014) Yuka Kinoshita et al.   BONE

Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia

(2014) Thomas O. Carpenter et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?

(2014) R. Sapir-Koren et al.   OSTEOPOROSIS INTERNATIONAL

Dysregulated Gene Expression in the Primary Osteoblasts and Osteocytes Isolated from Hypophosphatemic Hyp Mice

(2014) Kazuaki Miyagawa et al.   PLoS One

PHEX Mimetic (SPR4-Peptide) Corrects and Improves HYP and Wild Type Mice Energy-Metabolism

(2014) Lesya V. Zelenchuk et al.   PLoS One

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

(2014) V. S. Tagliabracci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

(2013) Ming Chang Hu et al.   Annual Review of Physiology

Increased Col10a1 expression is not causative for the phenotype of Phex-deficient Hyp mice

(2013) Timur Yorgan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia

(2013) Jian Q. Feng et al.   BONE

FGF23 Affects the Lineage Fate Determination of Mesenchymal Stem Cells

(2013) Yan Li et al.   CALCIFIED TISSUE INTERNATIONAL

Effects of Extracellular Phosphate on Gene Expression in Murine Osteoblasts

(2013) C. Rendenbach et al.   CALCIFIED TISSUE INTERNATIONAL

Osteocyte-Driven Bone Remodeling

(2013) Teresita Bellido   CALCIFIED TISSUE INTERNATIONAL

Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification

(2013) Silje Hjorth Rafaelsen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An integrated understanding of the physiological response to elevated extracellular phosphate

(2013) Corinne E. Camalier et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vitamin D Represses Dentin Matrix Protein 1 in Cementoblasts and Osteocytes

(2013) F.H. Nociti et al.   JOURNAL OF DENTAL RESEARCH

Early chronic kidney disease–mineral bone disorder stimulates vascular calcification

(2013) Yifu Fang et al.   KIDNEY INTERNATIONAL

Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium

(2013) Z. C. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear localization of DMP1 proteins suggests a role in intracellular signaling

(2012) Arwa Siyam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New insights into NPP1 function: Lessons from clinical and animal studies

(2012) N.C.W. Mackenzie et al.   BONE

Retinol deprivation partially rescues the skeletal mineralization defects of Phex-deficient Hyp mice

(2012) Sebastian Seitz et al.   BONE

An overview of the regulation of bone remodelling at the cellular level

(2012) Jasreen Kular et al.   CLINICAL BIOCHEMISTRY

Fibroblast Growth Factor 23 and Klotho Are Present in the Growth Plate

(2012) Adalbert Raimann et al.   CONNECTIVE TISSUE RESEARCH

Regulation of Bone−Renal Mineral and Energy Metabolism: The PHEX, FGF23, DMP1, MEPE ASARM Pathway

(2012) Peter S. N. Rowe   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease

(2012) L. Darryl Quarles   EXPERIMENTAL CELL RESEARCH

Phosphate/Pyrophosphate and MV-related Proteins in Mineralisation: Discoveries from Mouse Models

(2012) Xiaoying Zhou et al.   International Journal of Biological Sciences

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy

(2012) Yves Sabbagh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia

(2012) Nilana MT Barros et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality

(2012) Victoria Shalhoub et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells

(2012) Nobuaki Ito et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Calcium Deficiency Reduces Circulating Levels of FGF23

(2012) M. E. Rodriguez-Ortiz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community

(2012) Johan Ärnlöv et al.   KIDNEY INTERNATIONAL

FGF23 production by osteocytes

(2012) Lynda F. Bonewald et al.   PEDIATRIC NEPHROLOGY

Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice

(2012) Neil Charles Wallace Mackenzie et al.   PLoS One

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

(2012) N. M. Collette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization

(2012) V. S. Tagliabracci et al.   SCIENCE

Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice

(2012) Xiaofang Wang et al.   PLoS Genetics

Phosphate Sensing

(2011) Clemens Bergwitz et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo

(2011) Yumie Rhee et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Fibroblast Growth Factor 23 (FGF23) and Alpha-Klotho Stimulate Osteoblastic MC3T3.E1 Cell Proliferation and Inhibit Mineralization

(2011) V. Shalhoub et al.   CALCIFIED TISSUE INTERNATIONAL

Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling

(2011) Aline Martin et al.   FASEB JOURNAL

The expanding family of hypophosphatemic syndromes

(2011) Thomas O. Carpenter   JOURNAL OF BONE AND MINERAL METABOLISM

FGF-23/Klotho signaling is not essential for the phosphaturic and anabolic functions of PTH

(2011) Quan Yuan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism

(2011) Gerald J Atkins et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone

(2011) Simon Wöhrle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA methylation contributes to the regulation of sclerostin expression in human osteocytes

(2011) Jesús Delgado-Calle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo

(2011) Ignacio López et al.   KIDNEY INTERNATIONAL

Vitamin D metabolism within bone cells: Effects on bone structure and strength

(2011) Paul H. Anderson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

(2011) Dongxing Zhu et al.   PLoS One

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis

(2011) Mark R. Haussler et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Autosomal-Recessive Hypophosphatemic Rickets Is Associated with an Inactivation Mutation in the ENPP1 Gene

(2010) Varda Levy-Litan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss-of-Function ENPP1 Mutations Cause Both Generalized Arterial Calcification of Infancy and Autosomal-Recessive Hypophosphatemic Rickets

(2010) Bettina Lorenz-Depiereux et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals

(2010) Solmaz Khoshniat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Osteoclastic Metabolism of 25(OH)-Vitamin D3: A Potential Mechanism for Optimization of Bone Resorption

(2010) Masakazu Kogawa et al.   ENDOCRINOLOGY

Cellular and Molecular Mechanisms of Bone Remodeling

(2010) Liza J. Raggatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective bone formation by hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect

(2010) Brigitte Ecarot et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice

(2010) Ralph A. Meyer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cellular mechanisms of bone remodeling

(2010) Erik Fink Eriksen   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Parathyroid hormone signaling in bone and kidney

(2009) Minnkyong Lee et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Bone Formation Regulates Circulating Concentrations of Fibroblast Growth Factor 23

(2009) Rana Samadfam et al.   ENDOCRINOLOGY

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

(2009) Teruyo Nakatani et al.   FASEB JOURNAL

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase

(2009) Mutsuko Ohnishi et al.   KIDNEY INTERNATIONAL

Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone

(2009) Shiguang Liu et al.   MOLECULAR ENDOCRINOLOGY

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype

(2008) Xiuying Bai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

(2008) Teruyo Nakatani et al.   FASEB JOURNAL

Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice

(2008) Hironobu Suzuki et al.   JOURNAL OF ANATOMY

Overexpression of Fibroblast Growth Factor 23 Suppresses Osteoblast Differentiation and Matrix Mineralization In Vitro

(2008) Hua Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genetic Evidence of Serum Phosphate-Independent Functions of FGF-23 on Bone

(2008) Despina Sitara et al.   PLoS Genetics