Role of Nrf2 and Its Activators in Respiratory Diseases

Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia

(2018) Qian Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of an Unfavorable Immune Signature in Advanced Lung Tumors from Nrf2-Deficient Mice

(2018) Di Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 activation protects against intratracheal LPS induced mouse/murine acute respiratory distress syndrome by regulating macrophage polarization

(2018) Juan Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aucubin protects against lipopolysaccharide-induced acute pulmonary injury through regulating Nrf2 and AMPK pathways

(2018) Yan-Ling Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress

(2018) Jiaji Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway

(2018) Rui Qing et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways

(2018) Jianping Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway

(2018) Sara Vergel Posso et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nrf2 attenuates inflammatory response in COPD/emphysema: Crosstalk with Wnt3a/β-catenin and AMPK pathways

(2018) Wenhui Cui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway

(2018) Ying Lu et al.   PLoS One

Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane

(2018) Yuting Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protective mechanism of sulforaphane in Nrf2 and anti-lung injury in ARDS rabbits

(2018) Zongjian Sun et al.   Experimental and Therapeutic Medicine

NF-E2-related factor 2 serves a key function in resistance to malignant transformation of BEAS-2B cells induced by coal tar pitch

(2018) Songcheng Yu et al.   Oncology Letters

Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats

(2018) Sheng-Lan Tian et al.   MEDICAL SCIENCE MONITOR

Alleviation of Acute Lung Injury in Rats with Sepsis by Resveratrol via the Phosphatidylinositol 3-Kinase/Nuclear Factor-Erythroid 2 Related Factor 2/Heme Oxygenase-1 (PI3K/Nrf2/HO-1) Pathway

(2018) Yu Wang et al.   MEDICAL SCIENCE MONITOR

Protective Role of Nuclear Factor Erythroid 2-Related Factor 2 Against Respiratory Syncytial Virus and Human Metapneumovirus Infections

(2018) Teodora Ivanciuc et al.   Frontiers in Immunology

Protective effect of forsythiaside A on OVA-induced asthma in mice

(2017) Jin Qian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway

(2017) Liju Duan et al.   FOOD AND CHEMICAL TOXICOLOGY

Nuclear protein HMGN2 attenuates pyocyanin-induced oxidative stress via Nrf2 signaling and inhibits Pseudomonas aeruginosa internalization in A549 cells

(2017) Keyun Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice

(2017) Satoshi Ano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E isoform γ-tocotrienol protects against emphysema in cigarette smoke-induced COPD

(2017) Hong Yong Peh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 transfection enhances the efficacy of human amniotic mesenchymal stem cells to repair lung injury induced by lipopolysaccharide

(2017) Shouqin Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protective effects of syringin against lipopolysaccharide-induced acute lung injury in mice

(2017) Ao Zhang et al.   JOURNAL OF SURGICAL RESEARCH

The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer

(2017) Shasha Tao et al.   MOLECULAR CARCINOGENESIS

Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract

(2017) Zongxian Jiao et al.   Molecular Medicine Reports

Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways

(2017) Jian-Ping Dai et al.   MOLECULES

Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways

(2017) Li Lin et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoid quercetin

(2017) C. Veith et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium

(2017) Yuan Liu et al.   BMC Pulmonary Medicine

WDR23 regulates NRF2 independently of KEAP1

(2017) Jacqueline Y. Lo et al.   PLoS Genetics

Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2–Related Factor 2 Activation

(2016) Qian Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response

(2016) Lin-Lin Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma

(2016) Xueshibojie Liu et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Emerging roles of Nrf2 signal in non-small cell lung cancer

(2016) Yijun Tian et al.   Journal of Hematology & Oncology

Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide

(2016) W. S. Daniel Tan et al.   JOURNAL OF NATURAL PRODUCTS

The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway

(2016) Zhihui Wang et al.   Molecular Medicine Reports

Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad

(2016) Angelo Sparaneo et al.   Oxidative Medicine and Cellular Longevity

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

(2016) Robert A. Wise et al.   PLoS One

A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response

(2015) Tao Shen et al.   ANTIOXIDANTS & REDOX SIGNALING

Dysregulation of the Keap1–Nrf2 pathway in cancer: Figure 1

(2015) Hanna M. Leinonen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis

(2015) Ciric To et al.   CARCINOGENESIS

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

(2015) Narayana Komaravelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway

(2015) TIANJIE QI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation

(2015) Masaki Shoji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

(2015) Min-Che Tung et al.   Oncotarget

Noblesse Oblige: NRF2 Functions in the Airways

(2014) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Disruption of the Transcription Factor Nrf2 Promotes Pro-Oxidative Dendritic Cells That Stimulate Th2-Like Immunoresponsiveness upon Activation by Ambient Particulate Matter

(2014) M. A. Williams et al.   JOURNAL OF IMMUNOLOGY

Streptococcus pneumoniae–Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol

(2014) Janine Zahlten et al.   JOURNAL OF INFECTIOUS DISEASES

Curcumin protects the developing lung against long-term hyperoxic injury

(2013) R. Sakurai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ethyl gallate attenuates acute lung injury through Nrf2 signaling

(2013) Kamiya Mehla et al.   BIOCHIMIE

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status

(2013) Sharon A. McGrath-Morrow et al.   CYTOKINE

Functional Haplotypes in the Promoter Region of Transcription FactorNrf2in Chronic Obstructive Pulmonary Disease

(2013) Chung-Ching Hua et al.   DISEASE MARKERS

The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

(2013) Yu-Chieh Lin et al.   Evidence-based Complementary and Alternative Medicine

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

(2013) Hye-Youn Cho   Oxidative Medicine and Cellular Longevity

Roflumilast Inhibits Respiratory Syncytial Virus Infection in Human Differentiated Bronchial Epithelial Cells

(2013) Manuel Mata et al.   PLoS One

Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study

(2013) Palanivel Chitra et al.   TOXICOLOGY LETTERS

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeted Deletion of Nrf2 Impairs Lung Development and Oxidant Injury in Neonatal Mice

(2012) Hye-Youn Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis

(2012) Elise Artaud-Macari et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma

(2012) Jun-Ho Park et al.   BMB Reports

Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

(2012) SP Guan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma

(2012) Wanxing Eugene Ho et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism

(2012) Hemant Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus

(2012) Beata Kosmider et al.   RESPIRATORY RESEARCH

Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-β signaling

(2011) Reiko Sakurai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Viral-mediated Inhibition of Antioxidant Enzymes Contributes to the Pathogenesis of Severe Respiratory Syncytial Virus Bronchiolitis

(2011) Yashoda M. Hosakote et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Attenuation of Transforming Growth Factor–β–Stimulated Collagen Production in Fibroblasts by Quercetin-Induced Heme Oxygenase–1

(2011) Toshinobu Nakamura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nrf2 Regulates Chronic Lung Inflammation and B-Cell Responses to NontypeableHaemophilus influenzae

(2011) Amit A. Lugade et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Conditional Deletion ofNrf2in Airway Epithelium Exacerbates Acute Lung Injury and Impairs the Resolution of Inflammation

(2011) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lung Cancer: Epidemiology, Etiology, and Prevention

(2011) Charles S. Dela Cruz et al.   CLINICS IN CHEST MEDICINE

The pathogenesis of influenza virus infections: the contributions of virus and host factors

(2011) Satoshi Fukuyama et al.   CURRENT OPINION IN IMMUNOLOGY

Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo

(2011) Ryszard Dworski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

(2011) Matthew J. Kesic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice

(2011) Y. Yageta et al.   JOURNAL OF VIROLOGY

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

KPNA6 (Importin  7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response

(2011) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis

(2011) Gopinath S. Palanisamy et al.   PLoS One

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus

(2011) Michelle D. Tate et al.   VIRAL IMMUNOLOGY

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction

(2010) David Adenuga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene

(2010) D. Kalpana Deepa Priya et al.   BIOMEDICINE & PHARMACOTHERAPY

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment

(2010) Elizabeth R. Johnson et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Cancer Chemoprevention by Natural Products: How Far Have We Come?

(2010) Rajendra G. Mehta et al.   PHARMACEUTICAL RESEARCH

Effect of influenza vaccination on oxidative stress products in breath

(2010) Michael Phillips et al.   Journal of Breath Research

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

(2009) Sharon McGrath-Morrow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice

(2009) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Respiratory Syncytial Virus Induces Oxidative Stress by Modulating Antioxidant Enzymes

(2009) Yashoda M. Hosakote et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Deletion ofKeap1in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation

(2009) David J. Blake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

The functional impairment of natural killer cells during influenza virus infection

(2009) Hailong Guo et al.   IMMUNOLOGY AND CELL BIOLOGY

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

(2009) Tom van der Poll et al.   LANCET

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

(2008) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cancer Statistics, 2008

(2008) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[ a ]pyrene-treated mice: mechanism of its anti-initiating action

(2008) Rachana Garg et al.   CARCINOGENESIS

Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice

(2008) Ying Ji Li et al.   CLINICAL IMMUNOLOGY

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling

(2008) Narayanan Sriram et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY