Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2–Related Factor 2 Activation

Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels

(2016) Sarah J. Chapple et al.   FREE RADICAL BIOLOGY AND MEDICINE

TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

(2015) Marcus Cebula et al.   ANTIOXIDANTS & REDOX SIGNALING

PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice

(2015) Narsa M. Reddy et al.   PLoS One

Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia

(2014) Miranda J. Floen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation

(2013) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Curcumin protects the developing lung against long-term hyperoxic injury

(2013) R. Sakurai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome

(2013) Rodney D. Britt et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status

(2013) Sharon A. McGrath-Morrow et al.   CYTOKINE

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

(2013) Sonya V. Iverson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury

(2012) Morgan L. Locy et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeted Deletion of Nrf2 Impairs Lung Development and Oxidant Injury in Neonatal Mice

(2012) Hye-Youn Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose

(2012) Yatao Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin augments lung maturation, preventing neonatal lung injury by inhibiting TGF-β signaling

(2011) Reiko Sakurai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress

(2011) Peter M. Scarbrough et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

(2011) Justin R. Prigge et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

(2011) A. Boutten et al.   TRENDS IN MOLECULAR MEDICINE

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation

(2010) P. K. Mandal et al.   CANCER RESEARCH

Future applications of antioxidants in premature infants

(2010) Jennifer W Lee et al.   CURRENT OPINION IN PEDIATRICS

Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity

(2010) Michael R. Farrell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure

(2010) Markus Velten et al.   JOURNAL OF APPLIED PHYSIOLOGY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

(2009) Sharon McGrath-Morrow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice

(2009) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alterations of the Thioredoxin System by Hyperoxia

(2009) Trent E. Tipple et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

(2009) Elias S.J. Arnér   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1

(2009) Olle Rengby et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

(2009) Eng-Hui Chew et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoprotective Nrf2 Pathway Is Induced In Chronically Txnrd 1-Deficient Hepatocytes

(2009) Elena S. Suvorova et al.   PLoS One

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative Stress and Antioxidants in the Pathogenesis of Pulmonary Fibrosis: A Potential Role for Nrf2

(2007) Dianne M. Walters et al.   ANTIOXIDANTS & REDOX SIGNALING