Yeast as a model system for studying lipid homeostasis and function

Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae

(2012) Susan A. Henry et al.   GENETICS

Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels

(2012) Ursula Loizides-Mangold et al.   JOURNAL OF LIPID RESEARCH

Lipidomics of intact mitochondria by MALDI-TOF/MS

(2012) Roberto Angelini et al.   JOURNAL OF LIPID RESEARCH

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity

(2012) Arupratan Das et al.   NATURE CELL BIOLOGY

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics

(2012) Christian Klose et al.   PLoS One

Toward a global analysis of metabolites in regulatory mutants of yeast

(2011) Elizabeth M. Humston et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Regulation of Phospholipid Synthesis in the YeastSaccharomyces cerevisiae

(2011) George M. Carman et al.   Annual Review of Biochemistry

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Chemical Biology Approaches to Membrane Homeostasis and Function

(2011) Miwa Takahashi-Umebayashi et al.   CHIMIA

Lipid transfer and signaling at organelle contact sites: the tip of the iceberg

(2011) Alexandre Toulmay et al.   CURRENT OPINION IN CELL BIOLOGY

Yeast: An Experimental Organism for 21st Century Biology

(2011) David Botstein et al.   GENETICS

Two Pathways of Sphingolipid Biosynthesis Are Separated in the YeastPichia pastoris

(2011) Philipp Ternes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets as fat storage organelles inCaenorhabditis elegans

(2011) Ho Yi Mak   JOURNAL OF LIPID RESEARCH

Lipidomic analyses ofMycobacterium tuberculosisbased on accurate mass measurements and the novel “MtbLipidDB”

(2011) Mark J. Sartain et al.   JOURNAL OF LIPID RESEARCH

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

A yeast-based assay identifies drugs active against human mitochondrial disorders

(2011) E. Couplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lipidome of an epithelial cell line

(2011) Julio L. Sampaio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer’s disease pathology

(2011) Vincenza Frisardi et al.   PROGRESS IN LIPID RESEARCH

Cell Membranes: The Lipid Perspective

(2011) Ünal Coskun et al.   STRUCTURE

Generic Sorting of Raft Lipids into Secretory Vesicles in Yeast

(2011) Michal A. Surma et al.   TRAFFIC

The Sterol-Binding Protein Kes1/Osh4p Is a Regulator of Polarized Exocytosis

(2011) Gabriel Alfaro et al.   TRAFFIC

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Phosphatidylglucoside Forms Specific Lipid Domains on the Outer Leaflet of the Plasma Membrane

(2010) Motohide Murate et al.   BIOCHEMISTRY

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

(2010) Bart Smets et al.   CURRENT GENETICS

Sphingolipids and insulin resistance: the five Ws

(2010) Scott A Summers   CURRENT OPINION IN LIPIDOLOGY

Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

(2010) Dina Petranovic et al.   FEMS YEAST RESEARCH

Coordination of Storage Lipid Synthesis and Membrane Biogenesis

(2010) Maria L. Gaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Proteins Diffuse as Dynamic Complexes with Lipids

(2010) Perttu S. Niemelä et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipidomics era: Accomplishments and challenges

(2010) Maroun Bou Khalil et al.   MASS SPECTROMETRY REVIEWS

Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling

(2010) Manuel J. Villa-García et al.   MOLECULAR GENETICS AND GENOMICS

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

(2010) Oriol Gallego et al.   Molecular Systems Biology

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Plasma membrane topography and interpretation of single-particle tracks

(2010) Jeremy Adler et al.   NATURE METHODS

Lipid biochemists salute the genome

(2010) James G. Wallis et al.   PLANT JOURNAL

A New Fluorescence-Based Method Identifies Protein Phosphatases Regulating Lipid Droplet Metabolism

(2010) Bruno L. Bozaquel-Morais et al.   PLoS One

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism

(2010) B. P. Young et al.   SCIENCE

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

(2010) Maureen E Hillenmeyer et al.   GENOME BIOLOGY

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Coordination of Lipid Metabolism in Membrane Biogenesis

(2009) Axel Nohturfft et al.   Annual Review of Cell and Developmental Biology

Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis

(2009) Danielle Kemmer et al.   BMC MICROBIOLOGY

Systems biology of lipid metabolism: From yeast to human

(2009) Jens Nielsen   FEBS LETTERS

Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network

(2009) Robin W. Klemm et al.   JOURNAL OF CELL BIOLOGY

Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology

(2009) Xue Li Guan et al.   MOLECULAR BIOLOGY OF THE CELL

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

A protein kinase network regulates the function of aminophospholipid flippases

(2009) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

(2009) C. S. Ejsing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The yeast lysosome-like vacuole: Endpoint and crossroads

(2008) Sheena Claire Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism

(2008) Intawat Nookaew et al.   BMC Systems Biology

Regulation of Ceramide Biosynthesis by TOR Complex 2

(2008) Sofia Aronova et al.   Cell Metabolism

Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

(2008) Anne K Kenworthy   EMBO REPORTS

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

siRNA screening reveals JNK2 as an evolutionary conserved regulator of triglyceride homeostasis

(2008) Vinciane Grimard et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Sphingolipids.New insights into sphingolipid metabolism and function in budding yeast

(2008) Robert C. Dickson   JOURNAL OF LIPID RESEARCH

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE

Concentration of GPI-Anchored Proteins upon ER Exit in Yeast

(2008) Guillaume A. Castillon et al.   TRAFFIC

Lipidomics: a new window to biomedical frontiers

(2008) Matej Orešič et al.   TRENDS IN BIOTECHNOLOGY

Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

(2007) Matthew J. Brauer et al.   MOLECULAR BIOLOGY OF THE CELL

Informatics and computational strategies for the study of lipids

(2007) Laxman Yetukuri et al.   Molecular BioSystems