Mesenchymal–epithelial transition in development and reprogramming

Mapping the Mouse Cell Atlas by Microwell-Seq

(2018) Xiaoping Han et al.   CELL

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage

(2017) Shangtao Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Cell plasticity in epithelial homeostasis and tumorigenesis

(2017) Julia Varga et al.   NATURE CELL BIOLOGY

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

(2017) Fergal O’Farrell et al.   NATURE CELL BIOLOGY

Roles of Grainyhead-like transcription factors in cancer

(2017) S M Frisch et al.   ONCOGENE

Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells

(2017) Alexia I. Bachir et al.   Cold Spring Harbor Perspectives in Biology

Mesenchymal to Epithelial Transition Mediated by CDH1 Promotes Spontaneous Reprogramming of Male Germline Stem Cells to Pluripotency

(2017) Junhui An et al.   Stem Cell Reports

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

(2017) Muhammad Zaeem Noman et al.   OncoImmunology

Sequential EMT-MET induces neuronal conversion through Sox2

(2017) Songwei He et al.   Cell Discovery

Phosphoinositides in Control of Membrane Dynamics

(2016) Kay O. Schink et al.   Annual Review of Cell and Developmental Biology

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Cellular Metabolism and Induced Pluripotency

(2016) Jun Wu et al.   CELL

Adherens Junction and E-Cadherin complex regulation by epithelial polarity

(2016) Peter Coopman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure

(2016) Heather J. Ray et al.   DEVELOPMENT

Apicobasal polarity and Ras/Raf/MEK/ERK signalling in cancer

(2016) Juan Peng et al.   GUT

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

PAR3-aPKC regulates Tiam1 by modulating suppressive internal interactions

(2016) Kenji Matsuzawa et al.   MOLECULAR BIOLOGY OF THE CELL

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer

(2016) J. Antony et al.   Science Signaling

Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells

(2016) Shuai Gao et al.   Stem Cell Research & Therapy

SHIP2 Regulates Lumen Generation, Cell Division, and Ciliogenesis through the Control of Basolateral to Apical Lumen Localization of Aurora A and HEF 1

(2016) Ola Hamze-Komaiha et al.   Cell Reports

Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming

(2016) Kyung Tae Lim et al.   Cell Reports

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer

(2016) J. Antony et al.   Science Signaling

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

The origin of the mammalian kidney: implications for recreating the kidney in vitro

(2015) M. Takasato et al.   DEVELOPMENT

Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies

(2015) Alpha S. Yap et al.   DEVELOPMENTAL CELL

Epithelial polarity – Generating and integrating signals from the ECM with integrins

(2015) Aki Manninen   EXPERIMENTAL CELL RESEARCH

A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia

(2015) Wei Dong et al.   JOURNAL OF CELL BIOLOGY

Stiffness of Hydrogels Regulates Cellular Reprogramming Efficiency Through Mesenchymal-to-Epithelial Transition and Stemness Markers 

(2015) Bogyu Choi et al.   MACROMOLECULAR BIOSCIENCE

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Ultrastructural visualization of the Mesenchymal-to-Epithelial Transition during reprogramming of human fibroblasts to induced pluripotent stem cells

(2015) M.K. Høffding et al.   Stem Cell Research

Mechanisms of apical–basal axis orientation and epithelial lumen positioning

(2015) Arend W. Overeem et al.   TRENDS IN CELL BIOLOGY

Snail1 is required for the maintenance of the pancreatic acinar phenotype

(2015) Jordina Loubat-Casanovas et al.   Oncotarget

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells

(2014) Nobuaki Shiraki et al.   Cell Metabolism

Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming

(2014) Xiao Hu et al.   Cell Stem Cell

Kinome-wide Functional Analysis Highlights the Role of Cytoskeletal Remodeling in Somatic Cell Reprogramming

(2014) Kumi Sakurai et al.   Cell Stem Cell

A close look at the mammalian blastocyst: epiblast and primitive endoderm formation

(2014) Jérôme Artus et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The function and regulation of mesenchymal-to-epithelial transition in somatic cell reprogramming

(2014) Xiaodong Shu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor

(2014) Kazuhide Watanabe et al.   DEVELOPMENTAL CELL

Transcriptional Mechanisms Link Epithelial Plasticity to Adhesion and Differentiation of Epidermal Progenitor Cells

(2014) Briana Lee et al.   DEVELOPMENTAL CELL

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

Integrins and epithelial cell polarity

(2014) Jessica L. Lee et al.   JOURNAL OF CELL SCIENCE

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

(2014) Bryce W. Carey et al.   NATURE

Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions

(2014) W. Engl et al.   NATURE CELL BIOLOGY

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Primitive endoderm differentiation: from specification to epithelium formation

(2014) S. Hermitte et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

ZO-1 and ZO-2 Are Required for Extra-Embryonic Endoderm Integrity, Primitive Ectoderm Survival and Normal Cavitation in Embryoid Bodies Derived from Mouse Embryonic Stem Cells

(2014) Dominic C. Y. Phua et al.   PLoS One

Cardiac Cell Lineages that Form the Heart

(2014) S. M. Meilhac et al.   Cold Spring Harbor Perspectives in Medicine

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis

(2013) I. Akalay et al.   CANCER RESEARCH

De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity

(2013) Z. Yang et al.   DEVELOPMENT

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein

(2013) Aline Awad et al.   MOLECULAR BIOLOGY OF THE CELL

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells

(2013) Bruno Di Stefano et al.   NATURE

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT–MET mechanism for optimal reprogramming

(2013) Xiaopeng Liu et al.   NATURE CELL BIOLOGY

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

(2013) M. Takasato et al.   NATURE CELL BIOLOGY

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells

(2013) Christina M. Szalinski et al.   PLoS One

Epithelial to mesenchymal transition as a portal to stem cell characters embedded in gene networks

(2012) Naisana S. Asli et al.   BIOESSAYS

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

(2012) Jose M. Polo et al.   CELL

Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

(2012) Alexander von Gise et al.   CIRCULATION RESEARCH

Transcription factor AP-2  is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis

(2012) I. Choi et al.   DEVELOPMENT

Epithelial-mesenchymal transitions: insights from development

(2012) J. Lim et al.   DEVELOPMENT

Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration

(2012) Tomomi E. Kimura et al.   DEVELOPMENTAL BIOLOGY

Regulation of Microtubule Stability and Organization by Mammalian Par3 in Specifying Neuronal Polarity

(2012) She Chen et al.   DEVELOPMENTAL CELL

Phosphoinositide lipids and cell polarity: linking the plasma membrane to the cytocortex

(2012) Michael P. Krahn et al.   Essays in Biochemistry

Early events in cell adhesion and polarity during epithelial-mesenchymal transition

(2012) R. Y.-J. Huang et al.   JOURNAL OF CELL SCIENCE

Establishing epithelial glandular polarity: interlinked roles for ARF6, Rac1, and the matrix microenvironment

(2012) Christine L. Monteleon et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin-modifying enzymes as modulators of reprogramming

(2012) Tamer T. Onder et al.   NATURE

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium

(2012) Nasreen Akhtar et al.   NATURE CELL BIOLOGY

Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

(2012) Rumela Chakrabarti et al.   NATURE CELL BIOLOGY

Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming

(2012) Gaoyang Liang et al.   NATURE CELL BIOLOGY

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Highly Coordinated Proteome Dynamics during Reprogramming of Somatic Cells to Pluripotency

(2012) Jenny Hansson et al.   Cell Reports

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

Molecular Regulation of Lumen Morphogenesis

(2011) Anirban Datta et al.   CURRENT BIOLOGY

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

(2011) Sayaka Sekiya et al.   NATURE

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells

(2011) Deepa Subramanyam et al.   NATURE BIOTECHNOLOGY

Phosphoinositides in Cell Architecture

(2011) A. Shewan et al.   Cold Spring Harbor Perspectives in Biology

Cell Polarity in Eggs and Epithelia: Parallels and Diversity

(2010) Daniel St Johnston et al.   CELL

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation

(2010) Jianguang Du et al.   DEVELOPMENTAL BIOLOGY

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development

(2010) Frank Costantini et al.   DEVELOPMENTAL CELL

Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation

(2010) Yi Qin et al.   JOURNAL OF CELL BIOLOGY

Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours

(2010) Kyra Campbell et al.   MECHANISMS OF DEVELOPMENT

Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc

(2009) Nimet Maherali et al.   CURRENT BIOLOGY

Par3 and Dynein Associate to Regulate Local Microtubule Dynamics and Centrosome Orientation during Migration

(2009) Jan Schmoranzer et al.   CURRENT BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity

(2008) Wei Yu et al.   EMBO REPORTS

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

(2008) Timo H.-W. Lüdtke et al.   HEPATOLOGY

RhoA and microtubule dynamics control cell–basement membrane interaction in EMT during gastrulation

(2008) Yukiko Nakaya et al.   NATURE CELL BIOLOGY

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polarity complex proteins

(2007) Emeline Assémat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tight junction biogenesis during early development

(2007) Judith J. Eckert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES