Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

Distinct Compartments of the Proepicardial Organ Give Rise to Coronary Vascular Endothelial Cells

(2012) Tamar C. Katz et al.   DEVELOPMENTAL CELL

Target cell movement in tumor and cardiovascular diseases based on the epithelial–mesenchymal transition concept

(2011) Kian-Ngiap Chua et al.   ADVANCED DRUG DELIVERY REVIEWS

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Heart Valve Structure and Function in Development and Disease

(2011) Robert B. Hinton et al.   Annual Review of Physiology

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1

(2011) Noortje A. M. Bax et al.   BASIC RESEARCH IN CARDIOLOGY

Notch signaling in cardiac valve development and disease

(2011) Donal MacGrogan et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2

(2011) Manon C. Verhoeven et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

(2011) James J.H. Chong et al.   Cell Stem Cell

Hand2 Loss-of-Function in Hand1 -Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development

(2011) Ralston M. Barnes et al.   CIRCULATION RESEARCH

Signaling During Epicardium and Coronary Vessel Development

(2011) José María Pérez-Pomares et al.   CIRCULATION RESEARCH

Notch Signaling Regulates Smooth Muscle Differentiation of Epicardium-Derived Cells

(2011) Thomas Grieskamp et al.   CIRCULATION RESEARCH

Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling

(2011) Christopher L. Smith et al.   CIRCULATION RESEARCH

Differential Notch Signaling in the Epicardium Is Required for Cardiac Inflow Development and Coronary Vessel Morphogenesis

(2011) Gonzalo del Monte et al.   CIRCULATION RESEARCH

Thymosin Beta 4 Is Dispensable for Murine Cardiac Development and Function

(2011) Indroneal Banerjee et al.   CIRCULATION RESEARCH

tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

(2011) K. Kikuchi et al.   DEVELOPMENT

FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium

(2011) M. Vega-Hernandez et al.   DEVELOPMENT

Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2

(2011) J. A. Guadix et al.   DEVELOPMENT

The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior

(2011) Nora S. Sánchez et al.   DEVELOPMENTAL BIOLOGY

WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways

(2011) Alexander von Gise et al.   DEVELOPMENTAL BIOLOGY

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

(2011) Ryan S. Gray et al.   DEVELOPMENTAL CELL

Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

(2011) Kazu Kikuchi et al.   DEVELOPMENTAL CELL

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

(2011) Jinzhu Duan et al.   EMBO JOURNAL

Probing transcription-specific outputs of  -catenin in vivo

(2011) T. Valenta et al.   GENES & DEVELOPMENT

Efficient inducible Cre-mediated recombination in Tcf21cell lineages in the heart and kidney

(2011) Asha Acharya et al.   GENESIS

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

(2011) N. Itoh et al.   JOURNAL OF BIOCHEMISTRY

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

(2011) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes

(2011) Bin Zhou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

De novo cardiomyocytes from within the activated adult heart after injury

(2011) Nicola Smart et al.   NATURE

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

(2011) I. P. Moskowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitral Valve Endothelial Cells With Osteogenic Differentiation Potential

(2010) Jill Wylie-Sears et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic Deficiency of Plasminogen Activator Inhibitor-1 Promotes Cardiac Fibrosis in Aged Mice

(2010) Asish K. Ghosh et al.   CIRCULATION

Origins of Cardiac Fibroblasts

(2010) Elisabeth M. Zeisberg et al.   CIRCULATION RESEARCH

Epicardial–Myocardial Signaling Directing Coronary Vasculogenesis

(2010) Harold E. Olivey et al.   CIRCULATION RESEARCH

A Dynamic Notch Injury Response Activates Epicardium and Contributes to Fibrosis Repair

(2010) Jamie L. Russell et al.   CIRCULATION RESEARCH

Epicardial Spindle Orientation Controls Cell Entry into the Myocardium

(2010) Mingfu Wu et al.   DEVELOPMENTAL CELL

Cardiac malformations in Pdgfrα mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field

(2010) Noortje A.M. Bax et al.   DEVELOPMENTAL DYNAMICS

TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion

(2010) Evisabel A. Craig et al.   EXPERIMENTAL CELL RESEARCH

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

(2010) Luis Luna-Zurita et al.   JOURNAL OF CLINICAL INVESTIGATION

Coronary arteries form by developmental reprogramming of venous cells

(2010) Kristy Red-Horse et al.   NATURE

PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous retinoic acid regulates cardiac progenitor differentiation

(2010) S.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ErbB signaling in cardiac development and disease

(2010) Pablo Sanchez-Soria et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects

(2010) Dominique Langlois et al.   TRANSGENIC RESEARCH

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Roles of TGFβ and BMP during valvulo–septal endocardial cushion formation

(2009) Toshiyuki Yamagishi et al.   ANATOMICAL SCIENCE INTERNATIONAL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Active Adaptation of the Tethered Mitral Valve

(2009) Jacob P. Dal-Bianco et al.   CIRCULATION

Heart Valve Development

(2009) Michelle D. Combs et al.   CIRCULATION RESEARCH

FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation

(2009) David J. Pennisi et al.   DEVELOPMENTAL BIOLOGY

Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart

(2009) Bin Zhou et al.   DEVELOPMENTAL BIOLOGY

Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

(2009) Masaki Ieda et al.   DEVELOPMENTAL CELL

Heart-specific Deletion ofCnB1Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function

(2009) Marjorie Maillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart

(2009) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymosin β4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo

(2009) Ildiko Bock-Marquette et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tbx18 and the fate of epicardial progenitors

(2009) Vincent M. Christoffels et al.   NATURE

Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin

(2009) Ofelia M Martínez-Estrada et al.   NATURE GENETICS

T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgf 2 expression and endocardial cushion formation

(2009) M. Shirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium

(2008) Bin Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Epicardium-Derived Cells in Development of Annulus Fibrosis and Persistence of Accessory Pathways

(2008) Denise P. Kolditz et al.   CIRCULATION

Platelet-Derived Growth Factor Receptor β Signaling Is Required for Efficient Epicardial Cell Migration and Development of Two Distinct Coronary Vascular Smooth Muscle Cell Populations

(2008) Amy M. Mellgren et al.   CIRCULATION RESEARCH

Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity

(2008) Qing Ma et al.   DEVELOPMENTAL BIOLOGY

Signaling via the Tgf-β type I receptor Alk5 in heart development

(2008) Somyoth Sridurongrit et al.   DEVELOPMENTAL BIOLOGY

Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFβ

(2008) Anita F. Austin et al.   DEVELOPMENTAL DYNAMICS

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

(2008) Bin Zhou et al.   NATURE

A myocardial lineage derives from Tbx18 epicardial cells

(2008) Chen-Leng Cai et al.   NATURE

Transitions between epithelial and mesenchymal states in development and disease

(2008) Buzz Baum et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Expanding Role for Retinoid Signaling in Heart Development

(2008) Loretta L. Hoover et al.   TheScientificWorldJOURNAL