The mechanism of ageing: primary role of transposable elements in genome disintegration

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

Somatic mutations, genome mosaicism, cancer and aging

(2014) Jan Vijg   CURRENT OPINION IN GENETICS & DEVELOPMENT

PIWI proteins and PIWI-interacting RNAs in the soma

(2014) Robert J. Ross et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Activation of transposable elements during aging and neuronal decline in Drosophila

(2013) Wanhe Li et al.   NATURE NEUROSCIENCE

PIWI-interacting RNAs: from generation to transgenerational epigenetics

(2013) Maartje J. Luteijn et al.   NATURE REVIEWS GENETICS

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells

(2013) C. E. Juliano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl

(2012) Wei Zhu et al.   DEVELOPMENTAL BIOLOGY

Global heterochromatin loss

(2012) Amy Tsurumi et al.   Epigenetics

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal

(2011) Jianrong Wang et al.   CELL CYCLE

Somatic retrotransposition alters the genetic landscape of the human brain

(2011) J. Kenneth Baillie et al.   NATURE

Retrotransposition is associated with genome instability during chronological aging

(2011) P. H. Maxwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

(2011) A. P. Jason de Koning et al.   PLoS Genetics

A hypothesis on the role of transposons

(2010) Alessandro Fontana   BIOSYSTEMS

Somatic piRNA biogenesis

(2010) Phillip D Zamore   EMBO JOURNAL

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Somatic expression of LINE-1 elements in human tissues

(2010) Victoria P. Belancio et al.   NUCLEIC ACIDS RESEARCH

Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences

(2010) Pornrutsami Jintaridth et al.   PHYSIOLOGICAL GENOMICS

Evolution of the mutation rate

(2010) Michael Lynch   TRENDS IN GENETICS

Mobilizing diversity: transposable element insertions in genetic variation and disease

(2010) Kathryn A O'Donnell et al.   Mobile DNA

Small RNAs as Guardians of the Genome

(2009) Colin D. Malone et al.   CELL

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

(2009) Sean P. Curran et al.   NATURE

Small RNAs in transcriptional gene silencing and genome defence

(2009) Danesh Moazed   NATURE

Immortality and the base of multicellular life: Lessons from cnidarian stem cells

(2009) Hiroshi Watanabe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

(2008) Antonia Tomás-Loba et al.   CELL

Decline in genomic DNA methylation through aging in a cohort of elderly subjects

(2008) Valentina Bollati et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A systematic look at an old problem

(2008) Thomas B. L. Kirkwood   NATURE