Simulation of P2X-mediated calcium signalling in microglia

Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes

(2018) Bradley D. Stewart et al.   CELL CALCIUM

Synthesis and in vitro characterization of a P2X7 radioligand [ 123 I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

(2018) Hongjun Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MK2–TNF–Signaling Comes Full Circle

(2018) Manoj B. Menon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis

(2017) Conner I. Sandefur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models

(2017) Laurent Mackay et al.   PLoS Computational Biology

Insights into the channel gating of P2X receptors from structures, dynamics and small molecules

(2016) Jin Wang et al.   ACTA PHARMACOLOGICA SINICA

Calmodulin inhibition regulates morphological and functional changes related to the actin cytoskeleton in pure microglial cells

(2016) Melinda Szabo et al.   BRAIN RESEARCH BULLETIN

Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways

(2016) Flávia V. Santa-Cecília et al.   NEUROTOXICITY RESEARCH

P2X receptors

(2016) R. Alan North   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nociceptive transmission and modulation via P2X receptors in central pain syndrome

(2016) Yung-Hui Kuan et al.   Molecular Brain

Store-Operated Ca2+ Entry (SOCE) and Purinergic Receptor-Mediated Ca2+ Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation

(2016) Daniel F. Gilbert et al.   Frontiers in Molecular Neuroscience

Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition

(2015) Lalida Rojanathammanee et al.   Journal of Neuroinflammation

Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes

(2015) Hojjat Bazzazi et al.   JOURNAL OF PHYSIOLOGY-LONDON

The azetidine derivative, KHG26792 protects against ATP-induced activation of NFAT and MAPK pathways through P2X7 receptor in microglia

(2015) Eun-A Kim et al.   NEUROTOXICOLOGY

Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte

(2015) Raimond L. Winslow et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The Role of Ion Channels in Microglial Activation and Proliferation – A Complex Interplay between Ligand-Gated Ion Channels, K+ Channels, and Intracellular Ca2+

(2015) Martin James Stebbing et al.   Frontiers in Immunology

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Quantitative assessment of microglial morphology and density reveals remarkable consistency in the distribution and morphology of cells within the healthy prefrontal cortex of the rat

(2014) Ratchaniporn Kongsui et al.   Journal of Neuroinflammation

Calcineurin and glial signaling: neuroinflammation and beyond

(2014) Jennifer L Furman et al.   Journal of Neuroinflammation

Allosteric regulation of the P2X4 receptor channel pore dilation

(2014) Hana Zemkova et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles

(2014) Xiaoming Hu et al.   PROGRESS IN NEUROBIOLOGY

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

SnapShot: p38 MAPK Signaling

(2013) Natalia Trempolec et al.   CELL

Microglial Phenotype Is Regulated by Activity of the Transcription Factor, NFAT (Nuclear Factor of Activated T Cells)

(2013) K. Nagamoto-Combs et al.   JOURNAL OF NEUROSCIENCE

Imaging P2X4 Receptor Lateral Mobility in Microglia

(2012) Estelle Toulme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling

(2012) Anmar Khadra et al.   JOURNAL OF GENERAL PHYSIOLOGY

Computational Medicine: Translating Models to Clinical Care

(2012) R. L. Winslow et al.   Science Translational Medicine

Modeling Effects of L-Type Ca2+ Current and Na+-Ca2+ Exchanger on Ca2+ Trigger Flux in Rabbit Myocytes with Realistic T-Tubule Geometries

(2012) Peter M. Kekenes-Huskey et al.   Frontiers in Physiology

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)

(2011) D. S. K. Samways et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin

(2010) Estelle Toulme et al.   JOURNAL OF GENERAL PHYSIOLOGY

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

(2010) Z. Yan et al.   JOURNAL OF NEUROSCIENCE

Pathways for Cytokine Secretion

(2010) Amanda C. Stanley et al.   PHYSIOLOGY

Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes

(2009) Michael T. Cooling et al.   BIOPHYSICAL JOURNAL

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

NCX1 Expression and Functional Activity Increase in Microglia Invading the Infarct Core

(2009) Francesca Boscia et al.   STROKE

Calmodulin Mediates Differential Sensitivity of CaMKII and Calcineurin to Local Ca2+ in Cardiac Myocytes

(2008) Jeffrey J. Saucerman et al.   BIOPHYSICAL JOURNAL

Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT

(2008) Ayako Kataoka et al.   JOURNAL OF NEUROCHEMISTRY

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

How Does Intracellular Ca2+ Oscillate: By Chance or by the Clock?

(2007) Alexander Skupin et al.   BIOPHYSICAL JOURNAL

Temperature and nitric oxide control spontaneous calcium transients in astrocytes

(2007) Carola G. Schipke et al.   CELL CALCIUM

Lipopolysaccharide-induced down-regulation of Ca2+release-activated Ca2+currents (ICRAC) but not Ca2+-activated TRPM4-like currents (ICAN) in cultured mouse microglial cells

(2007) Andreas Beck et al.   JOURNAL OF PHYSIOLOGY-LONDON