Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte

Chasing cardiac physiology and pathology down the CaMKII cascade

(2015) Alicia Mattiazzi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structure and function of the mitochondrial calcium uniporter complex

(2015) Diego De Stefani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart

(2015) Panagiota T. Foteinou et al.   BIOPHYSICAL JOURNAL

Nuclear Calcium in Cardiac Myocytes

(2015) Senka Ljubojevic et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Functional implications of mitofusin 2-mediated mitochondrial-SR tethering

(2015) Gerald W. Dorn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

(2015) Jorge A. Negroni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges

(2015) Sander Land et al.   PLoS Computational Biology

On the Adjacency Matrix of RyR2 Cluster Structures

(2015) Mark A. Walker et al.   PLoS Computational Biology

Mechanisms for redox-regulation of protein kinase C

(2015) Susan F. Steinberg   Frontiers in Pharmacology

Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C

(2015) Sharon Weiss et al.   Current Molecular Pharmacology

Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice

(2014) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Two Regions of the Ryanodine Receptor Calcium Channel Are Involved in Ca2+-Dependent Inactivation

(2014) Angela C. Gomez et al.   BIOCHEMISTRY

Superresolution Modeling of Calcium Release in the Heart

(2014) Mark A. Walker et al.   BIOPHYSICAL JOURNAL

The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca2+ Handling during Rest in Rabbit Ventricular Myocytes

(2014) Elisa Bovo et al.   BIOPHYSICAL JOURNAL

Nitric Oxide Induces Ca2+-independent Activity of the Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII)

(2014) Steven J. Coultrap et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function

(2014) Franz Hofmann et al.   PHYSIOLOGICAL REVIEWS

Nitric Oxide-Dependent Activation of CaMKII Increases Diastolic Sarcoplasmic Reticulum Calcium Release in Cardiac Myocytes in Response to Adrenergic Stimulation

(2014) Jerry Curran et al.   PLoS One

Mechanisms of CaMKII Activation in the Heart

(2014) Jeffrey R. Erickson   Frontiers in Pharmacology

Modeling CaMKII-mediated regulation of L-type Ca2+ channels and ryanodine receptors in the heart

(2014) Joseph L. Greenstein et al.   Frontiers in Pharmacology

CaMKII-dependent regulation of cardiac Na+ homeostasis

(2014) Eleonora Grandi et al.   Frontiers in Pharmacology

An Integrated Mitochondrial ROS Production and Scavenging Model: Implications for Heart Failure

(2013) Laura D. Gauthier et al.   BIOPHYSICAL JOURNAL

Control of Sarcoplasmic Reticulum Ca2+ Release by Stochastic RyR Gating within a 3D Model of the Cardiac Dyad and Importance of Induction Decay for CICR Termination

(2013) M.B. Cannell et al.   BIOPHYSICAL JOURNAL

A Computational Model of Reactive Oxygen Species and Redox Balance in Cardiac Mitochondria

(2013) Laura D. Gauthier et al.   BIOPHYSICAL JOURNAL

A Mechanistic Model of Ca Regulation of Thin Filaments in Cardiac Muscle

(2013) Nadia A. Metalnikova et al.   BIOPHYSICAL JOURNAL

Integrating Mitochondrial Energetics, Redox and ROS Metabolic Networks: A Two-Compartment Model

(2013) Jackelyn M. Kembro et al.   BIOPHYSICAL JOURNAL

L-type calcium channel targeting and local signalling in cardiac myocytes

(2013) Robin M. Shaw et al.   CARDIOVASCULAR RESEARCH

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca2+ and reactive oxygen species signaling

(2013) V. Eisner et al.   JOURNAL OF CELL SCIENCE

Ultrastructure of cisternal synapses on outer hair cells of the mouse cochlea

(2013) Paul Albert Fuchs et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle

(2013) Dirk Gillespie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium signaling in cardiac mitochondria

(2013) Elena N. Dedkova et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pan-junctional sarcoplasmic reticulum in vascular smooth muscle: nanospace Ca2+transport for site- and function-specific Ca2+signalling

(2013) Cornelis van Breemen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial calcium uptake

(2013) G. S. B. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGMP–cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function

(2012) Alessandra Stangherlin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants

(2012) Moshe Giladi et al.   CELL CALCIUM

New Therapeutic Targets in Cardiology

(2012) Adam G. Rokita et al.   CIRCULATION

Cyclic GMP-Dependent Signaling in Cardiac Myocytes

(2012) Eiki Takimoto   CIRCULATION JOURNAL

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

(2012) Yun Chen et al.   CIRCULATION RESEARCH

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction

(2012) Eva Wagner et al.   CIRCULATION RESEARCH

Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal Insulin-Like Growth Factor 1 Receptors

(2012) Cristian Ibarra et al.   CIRCULATION RESEARCH

Measuring Local Gradients of Intramitochondrial [Ca 2+ ] in Cardiac Myocytes During Sarcoplasmic Reticulum Ca 2+ Release

(2012) Xiyuan Lu et al.   CIRCULATION RESEARCH

Dynamics of matrix-free Ca2+in cardiac mitochondria: two components of Ca2+uptake and role of phosphate buffering

(2012) An-Chi Wei et al.   JOURNAL OF GENERAL PHYSIOLOGY

Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy

(2012) Jason H. Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Theoretical investigation of the mechanism of heart failure using a canine ventricular cell model: Especially the role of up-regulated CaMKII and SR Ca2+ leak

(2012) Yunliang Zang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

(2012) D.R. Laver et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit

(2012) Johan Hake et al.   JOURNAL OF PHYSIOLOGY-LONDON

An analysis of deformation-dependent electromechanical coupling in the mouse heart

(2012) Sander Land et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes

(2012) I. Drago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Signaling in Dendritic Spines

(2012) M. J. Higley et al.   Cold Spring Harbor Perspectives in Biology

Toward an Integrative Computational Model of the Guinea Pig Cardiac Myocyte

(2012) Laura Doyle Gauthier et al.   Frontiers in Physiology

Dynamics of Calcium Sparks and Calcium Leak in the Heart

(2011) George S.B. Williams et al.   BIOPHYSICAL JOURNAL

How Does Stochastic Ryanodine Receptor-Mediated Ca Leak Fail to Initiate a Ca Spark?

(2011) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

In Situ Calibration of Nucleoplasmic versus Cytoplasmic Ca2+ Concentration in Adult Cardiomyocytes

(2011) Senka Ljubojević et al.   BIOPHYSICAL JOURNAL

Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload

(2011) Stefan Wagner et al.   CIRCULATION RESEARCH

Integrative Systems Models of Cardiac Excitation–Contraction Coupling

(2011) Joseph L. Greenstein et al.   CIRCULATION RESEARCH

Computational Models Reduce Complexity and Accelerate Insight Into Cardiac Signaling Networks

(2011) Jason H. Yang et al.   CIRCULATION RESEARCH

Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: From contractility to remodeling

(2011) Joanna Hammond et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Cardiac Electromechanical Models: From Cell to Organ

(2011) Natalia A. Trayanova et al.   Frontiers in Physiology

Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2+ Handling

(2010) Anthony R. Soltis et al.   BIOPHYSICAL JOURNAL

Coupling of Adjacent Tropomyosins Enhances Cross-Bridge-Mediated Cooperative Activation in a Markov Model of the Cardiac Thin Filament

(2010) Stuart G. Campbell et al.   BIOPHYSICAL JOURNAL

Nuclear Ca2+ signalling

(2010) Maria Teresa Alonso et al.   CELL CALCIUM

Spark-Induced Sparks As a Mechanism of Intracellular Calcium Alternans in Cardiac Myocytes

(2010) Robert Rovetti et al.   CIRCULATION RESEARCH

Quarky Calcium Release in the Heart

(2010) Didier X.P. Brochet et al.   CIRCULATION RESEARCH

Essential Role of the CBD1-CBD2 Linker in Slow Dissociation of Ca2+from the Regulatory Two-domain Tandem of NCX1

(2010) Moshe Giladi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of CaMKII in RyR leak, EC coupling and action potential duration: A computational model

(2010) Yasmin L. Hashambhoy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structural evidence for perinuclear calcium microdomains in cardiac myocytes

(2010) Matias Escobar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of reverse Na+-Ca2+exchange by the Na+current augments the cardiac Ca2+transient: evidence from NCX knockout mice

(2010) Robert Larbig et al.   JOURNAL OF PHYSIOLOGY-LONDON

Na+currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+channels

(2010) Natalia S. Torres et al.   JOURNAL OF PHYSIOLOGY-LONDON

Models of cardiac excitation–contraction coupling in ventricular myocytes

(2010) George S.B. Williams et al.   MATHEMATICAL BIOSCIENCES

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes

(2010) P. Li et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

Arrhythmogenic consequences of intracellular calcium waves

(2009) Lai-Hua Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Organization of Ryanodine Receptors, Transverse Tubules, and Sodium-Calcium Exchanger in Rat Myocytes

(2009) Isuru D. Jayasinghe et al.   BIOPHYSICAL JOURNAL

CaMKII-Induced Shift in Modal Gating Explains L-Type Ca2+ Current Facilitation: A Modeling Study

(2009) Yasmin L. Hashambhoy et al.   BIOPHYSICAL JOURNAL

cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies

(2009) Manuela Zaccolo   BRITISH JOURNAL OF PHARMACOLOGY

Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice

(2009) Nadine Beetz et al.   CARDIOVASCULAR RESEARCH

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death

(2009) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Sarcoplasmic reticulum Ca2+ATPase as a therapeutic target for heart failure

(2009) Larissa Lipskaia et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The L-type Ca2+ Channel as a Potential Mediator of Pathology During Alterations in Cellular Redox State

(2009) Livia C. Hool   Heart Lung and Circulation

Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca2+ regulation

(2009) Marina Cerrone et al.   HEART RHYTHM

Mitochondria in cardiomyocyte Ca2+ signaling

(2009) Valeriy Lukyanenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of mitochondrial Ca2+ and its effects on energetics and redox balance in normal and failing heart

(2009) Ting Liu et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Roles of Two Ca2+-binding Domains in Regulation of the Cardiac Na+-Ca2+Exchanger

(2009) Michela Ottolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart

(2009) T. Hayashi et al.   JOURNAL OF CELL SCIENCE

An update on nuclear calcium signalling

(2009) M. D. Bootman et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Ca2+ uptake: Tortoise or hare?

(2009) Brian O'Rourke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes

(2009) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Dilated Cardiomyopathy with Increased SR Ca2+ Loading Preceded by a Hypercontractile State and Diastolic Failure in the α1CTG Mouse

(2009) Su Wang et al.   PLoS One

Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

(2009) David Baddeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum

(2009) G. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of the Frank–Starling Law in the Transduction of Cellular Work to Whole Organ Pump Function: A Computational Modeling Analysis

(2009) Steven A. Niederer et al.   PLoS Computational Biology

Allosteric Activation of Na+-Ca2+ Exchange by L-Type Ca2+ Current Augments the Trigger Flux for SR Ca2+ Release in Ventricular Myocytes

(2008) Eric A. Sobie et al.   BIOPHYSICAL JOURNAL

Approximate Model of Cooperative Activation and Crossbridge Cycling in Cardiac Muscle Using Ordinary Differential Equations

(2008) John Jeremy Rice et al.   BIOPHYSICAL JOURNAL

Calmodulin Mediates Differential Sensitivity of CaMKII and Calcineurin to Local Ca2+ in Cardiac Myocytes

(2008) Jeffrey J. Saucerman et al.   BIOPHYSICAL JOURNAL

Mechanism of Local and Global Ca2+ Sensing by Calmodulin in Complex with a Ca2+ Channel

(2008) Michael R. Tadross et al.   CELL

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Mechanisms Underlying Rate-Dependent Remodeling of Transient Outward Potassium Current in Canine Ventricular Myocytes

(2008) Ling Xiao et al.   CIRCULATION RESEARCH

Termination of Cardiac Ca 2+ Sparks

(2008) Aleksey V. Zima et al.   CIRCULATION RESEARCH

Enhancing Mitochondrial Ca 2+ Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching

(2008) Ting Liu et al.   CIRCULATION RESEARCH

Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling

(2008) Lai-Hua Xie et al.   CIRCULATION RESEARCH

Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling

(2008) Thomas J. Hund et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels

(2008) Ivy E. Dick et al.   NATURE

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

Calcium Cycling and Signaling in Cardiac Myocytes

(2007) Donald M. Bers   Annual Review of Physiology