Calcineurin and glial signaling: neuroinflammation and beyond

FK506 Reduces Amyloid Plaque Burden and Induces MMP-9 in AβPP/PS1 Double Transgenic Mice

(2017) Hyun-Seok Hong et al.   JOURNAL OF ALZHEIMERS DISEASE

The dual face of connexin-based astroglial Ca2+ communication: A key player in brain physiology and a prime target in pathology

(2014) Marijke De Bock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus

(2014) Hong Q. Yan et al.   BRAIN RESEARCH

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

(2013) Diana M. Sama et al.   AGEING RESEARCH REVIEWS

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

NFATc3 promotes Ca2+-dependent MMP3 expression in astroglial cells

(2013) Fernando Neria et al.   GLIA

Microglial Phenotype Is Regulated by Activity of the Transcription Factor, NFAT (Nuclear Factor of Activated T Cells)

(2013) K. Nagamoto-Combs et al.   JOURNAL OF NEUROSCIENCE

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury

(2013) Niklas Marklund et al.   JOURNAL OF NEUROTRAUMA

Pomegranate Polyphenols and Extract Inhibit Nuclear Factor of Activated T-Cell Activity and Microglial Activation In Vitro and in a Transgenic Mouse Model of Alzheimer Disease

(2013) Lalida Rojanathammanee et al.   JOURNAL OF NUTRITION

Neuroinflammatory Phenotypes and Their Roles in Alzheimer's Disease

(2013) Donna M. Wilcock   Neurodegenerative Diseases

Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

(2013) Juan A. Orellana et al.   NEUROPHARMACOLOGY

Alterations in connexin 43 phosphorylation during the progression of Alzheimer's disease: Possible role of astrocytic calcineurin

(2012) Jennifer Furman et al.   Alzheimers & Dementia

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Aβ-induced Ca2+ influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals

(2012) Seok Min Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glial cells in (patho)physiology

(2012) Vladimir Parpura et al.   JOURNAL OF NEUROCHEMISTRY

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

(2012) Eliseo A. Eugenin et al.   Journal of Neuroimmune Pharmacology

The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

(2012) Jie Fang et al.   Journal of Neuroinflammation

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

(2012) Elina M Sutinen et al.   Journal of Neuroinflammation

Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease

(2012) E. Hudry et al.   JOURNAL OF NEUROSCIENCE

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Neural functions of calcineurin in synaptic plasticity and memory

(2012) K. Baumgartel et al.   LEARNING & MEMORY

Aβ leads to Ca2+ signaling alterations and transcriptional changes in glial cells

(2012) Ambra A. Grolla et al.   NEUROBIOLOGY OF AGING

Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages

(2011) Rei Yamaguchi et al.   BRAIN RESEARCH

Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists

(2011) Martine Tencé et al.   CELLULAR SIGNALLING

Regulatory Mechanisms of Calcineurin Phosphatase Activity

(2011) R. E.A. Musson et al.   CURRENT MEDICINAL CHEMISTRY

A Role for Calcineurin in Alzheimers Disease

(2011) Lindsay C. Reese et al.   Current Neuropharmacology

The Ca2+-dependent Phosphatase Calcineurin Controls the Formation of the Carma1-Bcl10-Malt1 Complex during T Cell Receptor-induced NF-κB Activation

(2011) Lysann Palkowitsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uridine 5'-Diphosphate Induces Chemokine Expression in Microglia and Astrocytes through Activation of the P2Y6 Receptor

(2011) B. Kim et al.   JOURNAL OF IMMUNOLOGY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology

(2011) A M Fernandez et al.   MOLECULAR PSYCHIATRY

Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: Identification of a subpopulation of reactive astrocytes

(2010) María C. Serrano-Pérez et al.   GLIA

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

(2010) Miho Shiratori et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca 2+ Channel

(2009) Samvit Tandan et al.   CIRCULATION RESEARCH

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal and Cognitive Aging across the Lifespan: A Bioenergetic Shift Precedes and Increased Cholesterol Trafficking Parallels Memory Impairment

(2009) I. Kadish et al.   JOURNAL OF NEUROSCIENCE

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Activated astroglia during chronic inflammation in Alzheimer's disease—Do they neglect their neurosupportive roles?

(2009) Stacey Fuller et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Disparate effects of serum on basal and evoked NFAT activity in primary astrocyte cultures

(2009) Jennifer L. Furman et al.   NEUROSCIENCE LETTERS

NFAT isoforms control activity-dependent muscle fiber type specification

(2009) E. Calabria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome

(2009) Sarah Dunn Keene et al.   PROTEOMICS

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

(2008) Lindsay C. Reese et al.   AGING CELL

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling

(2008) Hyun Jin Cho et al.   AGING CELL

A Lack of Amyloid β Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long-Term Survivors of Traumatic Brain Injury

(2008) Xiao-Han Chen et al.   BRAIN PATHOLOGY

Mechanical lesion activates newly identified NFATc1 in primary astrocytes: implication of ATP and purinergic receptors

(2008) José M. Pérez-Ortiz et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Differential involvement of TNFα in hypoxic suppression of astrocyte glutamate transporters

(2008) Hannah E. Boycott et al.   GLIA

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes

(2008) Andrea Canellada et al.   GLIA

Interleukin-1β-dependent Signaling between Astrocytes and Neurons Depends Critically on Astrocytic Calcineurin/NFAT Activity

(2008) Michelle A. Sama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT

(2008) Ayako Kataoka et al.   JOURNAL OF NEUROCHEMISTRY

Deafferentation-Induced Activation of NFAT (Nuclear Factor of Activated T-Cells) in Cochlear Nucleus Neurons during a Developmental Critical Period: A Role for NFATc4-Dependent Apoptosis in the CNS

(2008) J. I. Luoma et al.   JOURNAL OF NEUROSCIENCE

Proteomics-Determined Differences in the Concanavalin-A-Fractionated Proteome of Hippocampus and Inferior Parietal Lobule in Subjects with Alzheimer’s Disease and Mild Cognitive Impairment: Implications for Progression of AD

(2008) Joshua B. Owen et al.   JOURNAL OF PROTEOME RESEARCH

Hippocampal ‘zipper’ slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca2+ channels with aging

(2008) Christopher M. Norris et al.   NEUROBIOLOGY OF AGING

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Overactivation of calcineurin induced by amyloid-beta and prion proteins

(2008) Paula Agostinho et al.   NEUROCHEMISTRY INTERNATIONAL

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid β-peptide

(2007) Rukhsana Sultana et al.   Molecular BioSystems