Biomarker Discovery for Immunotherapy of Pituitary Adenomas: Enhanced Robustness and Prediction Ability by Modern Computational Tools

What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation

(2018) Weiwei Xue et al.   ACS Chemical Neuroscience

Exploring the Binding Mechanism of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators in Clinical Trials by Molecular Dynamics Simulations

(2018) Tingting Fu et al.   ACS Chemical Neuroscience

Intelligent and effective informatic deconvolution of “Big Data” and its future impact on the quantitative nature of neurodegenerative disease therapy

(2018) Stuart Maudsley et al.   Alzheimers & Dementia

Application of a Deep Neural Network to Metabolomics Studies and Its Performance in Determining Important Variables

(2018) Yasuhiro Date et al.   ANALYTICAL CHEMISTRY

The occurrence of benign brain tumours in transgender individuals during cross-sex hormone treatment

(2018) Nienke M Nota et al.   BRAIN

Functions and mechanisms of tumor necrosis factor-α and noncoding RNAs in bone-invasive pituitary adenomas

(2018) Haibo Zhu et al.   CLINICAL CANCER RESEARCH

The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes

(2018) Matthew P. Salomon et al.   CLINICAL CANCER RESEARCH

Arsenic Exposure from Drinking Water and Urinary Metabolomics: Associations and Long-Term Reproducibility in Bangladesh Adults

(2018) Fen Wu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra

(2018) Mychal S. Grames et al.   FASEB JOURNAL

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

(2018) Mirna Šimurina et al.   GASTROENTEROLOGY

Assessing the Performances of Protein Function Prediction Algorithms from the Perspectives of Identification Accuracy and False Discovery Rate

(2018) Chun Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Participation of the mPRα in the inhibitory effect of progesterone on prolactin secretion

(2018) María Andrea Camilletti et al.   JOURNAL OF NEUROENDOCRINOLOGY

Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H

(2018) Fengyuan Yang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Computational identification of the binding mechanism of a triple reuptake inhibitor amitifadine for the treatment of major depressive disorder

(2018) Weiwei Xue et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Clinical Success of Drug Targets Prospectively Predicted by In Silico Study

(2018) Feng Zhu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Discovery of the Consistently Well-Performed Analysis Chain for SWATH-MS Based Pharmacoproteomic Quantification

(2018) Jianbo Fu et al.   Frontiers in Pharmacology

Immunotherapy is not for all comers in chemotherapy-refractory advanced gastric cancer. Better predictive biomarkers are needed

(2018) E C Smyth et al.   ANNALS OF ONCOLOGY

Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis

(2018) Zhi-Jie Han et al.   CNS Neuroscience & Therapeutics

Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies

(2018) Margherita Brindisi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Marked response of a hypermutated adrenocorticotropic hormone-secreting pituitary carcinoma to ipilimumab and nivolumab

(2018) Andrew L Lin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

What Makes Species Productive of Anti-Cancer Drugs? Clues from Drugs` Species Origin, Druglikeness, Target and Pathway

(2018) Xiaofeng Li et al.   Anti-Cancer Agents in Medicinal Chemistry

ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies

(2018) Jing Tang et al.   BRIEFINGS IN BIOINFORMATICS

The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death

(2018) Maciej Kaliszczak et al.   BRITISH JOURNAL OF CANCER

Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters

(2018) Weiwei Xue et al.   CURRENT MEDICINAL CHEMISTRY

Computational Advances in the Label-free Quantification of Cancer Proteomics Data

(2018) Jing Tang et al.   CURRENT PHARMACEUTICAL DESIGN

Prediction of GluN2B-CT1290-1310/DAPK1 Interaction by Protein–Peptide Docking and Molecular Dynamics Simulation

(2018) Gao Tu et al.   MOLECULES

Determining the Balance Between Drug Efficacy and Safety by the Network and Biological System Profile of Its Therapeutic Target

(2018) Xiao xu Li et al.   Frontiers in Pharmacology

Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs

(2018) Ying Hong Li et al.   BRIEFINGS IN BIOINFORMATICS

Diagnosis and Treatment of Pituitary Adenomas

(2017) Mark E. Molitch   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction

(2017) Lili Song et al.   JOURNAL OF PROTEOME RESEARCH

Detection of programmed death ligand 1 protein and CD8+ lymphocyte infiltration in plurihormonal pituitary adenomas

(2017) Pengfei Wang et al.   MEDICINE

Development of Multimarker Diagnostic Models from Metabolomics Analysis for Gestational Diabetes Mellitus (GDM)

(2017) Wolin Hou et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas

(2017) Garima Yagnik et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Comparison of computational model and X-ray crystal structure of human serotonin transporter: potential application for the pharmacology of human monoamine transporters

(2017) Fengyuan Yang et al.   MOLECULAR SIMULATION

NOREVA: normalization and evaluation of MS-based metabolomics data

(2017) Bo Li et al.   NUCLEIC ACIDS RESEARCH

Revealing vilazodone's binding mechanism underlying its partial agonism to the 5-HT1A receptor in the treatment of major depressive disorder

(2017) Guoxun Zheng et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Role of tyrosine kinase inhibitors in the treatment of pituitary tumours

(2017) Anat Ben-Shlomo et al.   Current Opinion in Endocrinology Diabetes and Obesity

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

Large-Scale Prediction of Collision Cross-Section Values for Metabolites in Ion Mobility-Mass Spectrometry

(2016) Zhiwei Zhou et al.   ANALYTICAL CHEMISTRY

Urine metabolome profiling of immune-mediated inflammatory diseases

(2016) Arnald Alonso et al.   BMC Medicine

A systematic evaluation of normalization methods in quantitative label-free proteomics

(2016) Tommi Välikangas et al.   BRIEFINGS IN BIOINFORMATICS

Management of hormone-secreting pituitary adenomas

(2016) Gautam U. Mehta et al.   NEURO-ONCOLOGY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Identification of the inhibitory mechanism of FDA approved selective serotonin reuptake inhibitors: an insight from molecular dynamics simulation study

(2016) Weiwei Xue et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Current and Emerging Aspects of Diabetes Mellitus in Acromegaly

(2016) Stefano Frara et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Integrative proteomics and transcriptomics identify novel invasive-related biomarkers of non-functioning pituitary adenomas

(2016) Sheng-Yuan Yu et al.   TUMOR BIOLOGY

Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks

(2016) Jingyu Xu et al.   Biomed Research International

The Human Kinome Targeted by FDA Approved Multi-Target Drugs and Combination Products: A Comparative Study from the Drug-Target Interaction Network Perspective

(2016) Ying Hong Li et al.   PLoS One

Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study

(2016) Guoxun Zheng et al.   Scientific Reports

Performance Evaluation and Online Realization of Data-driven Normalization Methods Used in LC/MS based Untargeted Metabolomics Analysis

(2016) Bo Li et al.   Scientific Reports

Temozolomide induced bone marrow Suppression-A single institution outcome analysis and review of the literature

(2015) Taxiarchis V. Kourelis et al.   AMERICAN JOURNAL OF HEMATOLOGY

Temozolomide therapy in patients with aggressive pituitary adenomas or carcinomas

(2015) Marco Losa et al.   JOURNAL OF NEURO-ONCOLOGY

A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease

(2015) Mathias Riebold et al.   NATURE MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

(2015) Hong Yang et al.   NUCLEIC ACIDS RESEARCH

Co-targeting cancer drug escape pathways confers clinical advantage for multi-target anticancer drugs

(2015) Lin Tao et al.   PHARMACOLOGICAL RESEARCH

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

Programming tools: Adventures with R

(2014) Sylvia Tippmann   NATURE

The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance

(2014) Charles Wang et al.   NATURE BIOTECHNOLOGY

Aggressive pituitary adenomas—diagnosis and emerging treatments

(2014) Antonio Di Ieva et al.   Nature Reviews Endocrinology

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Batch effect removal methods for microarray gene expression data integration: a survey

(2012) C. Lazar et al.   BRIEFINGS IN BIOINFORMATICS

Pituitary carcinomas and aggressive pituitary tumours: merits and pitfalls of temozolomide treatment

(2012) Gérald Raverot et al.   CLINICAL ENDOCRINOLOGY

Genomic Characterization of Human and Rat Prolactinomas

(2012) Yunguang Tong et al.   ENDOCRINOLOGY

Gene Expression Profiling Identifies ESRP1 as a Potential Regulator of Epithelial Mesenchymal Transition in Somatotroph Adenomas from a Large Cohort of Patients with Acromegaly

(2012) Tove Lekva et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide expression profiling of schizophrenia using a large combined cohort

(2012) M Mistry et al.   MOLECULAR PSYCHIATRY

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

Drug Discovery Prospect from Untapped Species: Indications from Approved Natural Product Drugs

(2012) Feng Zhu et al.   PLoS One

Integrated Genomic Profiling Identifies Loss of Chromosome 11p Impacting Transcriptomic Activity in Aggressive Pituitary PRL Tumors

(2011) Anne Wierinckx et al.   BRAIN PATHOLOGY

Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism

(2011) Xun Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of Growth Arrest and DNA-Damage-Inducible Gene β (GADD45β) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors

(2011) Katherine A. Michaelis et al.   ENDOCRINOLOGY

Aggressive pituitary tumours: the role of temozolomide and the assessment of MGMT status

(2011) Ann I. McCormack et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Analysis of Differential Gene Expression by Bead-based Fiber-Optic Array in Nonfunctioning Pituitary Adenomas

(2011) Z. Jiang et al.   HORMONE AND METABOLIC RESEARCH

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

Localization of Carboxyl Ester Lipase in Human Pituitary Gland and Pituitary Adenomas

(2010) Stefano La Rosa et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Role of stereotactic radiosurgery in the management of pituitary adenomas

(2010) Frederic Castinetti et al.   Nature Reviews Endocrinology

PiRaNhA: a server for the computational prediction of RNA-binding residues in protein sequences

(2010) Y. Murakami et al.   NUCLEIC ACIDS RESEARCH

Trends in the Exploration of Anticancer Targets and Strategies in Enhancing the Efficacy of Drug Targeting

(2010) F. Zhu et al.   Current Molecular Pharmacology

What Are Next Generation Innovative Therapeutic Targets? Clues from Genetic, Structural, Physicochemical, and Systems Profiles of Successful Targets

(2009) F. Zhu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Update of TTD: Therapeutic Target Database

(2009) Feng Zhu et al.   NUCLEIC ACIDS RESEARCH

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA