A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein

(2014) Oliver Robin Lorenz et al.   MOLECULAR CELL

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Uncovering a Region of Heat Shock Protein 90 Important for Client Binding in E. coli and Chaperone Function in Yeast

(2012) Olivier Genest et al.   MOLECULAR CELL

Elucidation of the Hsp90 C-Terminal Inhibitor Binding Site

(2011) Robert L. Matts et al.   ACS Chemical Biology

Management of Cushing disease

(2011) Nicholas A. Tritos et al.   Nature Reviews Endocrinology

Identification and initial SAR of silybin: An Hsp90 inhibitor

(2010) Huiping Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dynamics-Based Discovery of Allosteric Inhibitors: Selection of New Ligands for the C-terminal Domain of Hsp90

(2010) Giulia Morra et al.   Journal of Chemical Theory and Computation

Multitargeted therapy of cancer by silymarin

(2008) Kumaraguruparan Ramasamy et al.   CANCER LETTERS

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY