New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease

Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats

(2018) Gisele K. Couto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginase up-regulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction

(2018) Isabelle Grandvuillemin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Environmental Stressors and Their Impact on Health and Disease with Focus on Oxidative Stress

(2018) Thomas Münzel et al.   ANTIOXIDANTS & REDOX SIGNALING

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression

(2018) Gillian Douglas et al.   CARDIOVASCULAR RESEARCH

Role of endothelial and macrophage tetrahydrobiopterin in development and progression of atherosclerosis: BH4 puzzle solved?

(2018) Thomas Münzel et al.   CARDIOVASCULAR RESEARCH

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation

(2018) Swenja Kröller-Schön et al.   EUROPEAN HEART JOURNAL

Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation

(2018) Elza van Deel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Environmental Noise and the Cardiovascular System

(2018) Thomas Münzel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis

(2018) Cristina Espinosa-Díez et al.   Redox Biology

Effects of gaseous and solid constituents of air pollution on endothelial function

(2018) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I

(2018) Zhichao Zhou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tetrahydrobiopterin improves endothelial function in patients with cystic fibrosis

(2018) Jin Hee Jeong et al.   JOURNAL OF APPLIED PHYSIOLOGY

Resistance exercise mediates remote ischemic preconditioning by limiting cardiac eNOS uncoupling

(2018) Michael Nadson Santos Santana et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endothelial nitric oxide synthase enhancer AVE3085 reverses endothelial dysfunction induced by homocysteine in human internal mammary arteries

(2018) Hai-Tao Hou et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice

(2017) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits

(2017) Yuan Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fecal microbiota transplantation (FMT) could reverse the severity of experimental necrotizing enterocolitis (NEC) via oxidative stress modulation

(2017) Xiaomei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of cardiovascular inflammation – Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

(2017) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase

(2017) Yanti Octavia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Selective impairment of blood pressure reduction by endothelial nitric oxide synthase dimer destabilization in mice

(2017) Tatsiana Suvorava et al.   JOURNAL OF HYPERTENSION

Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015

(2017) Aaron J Cohen et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contribution of glutaredoxin-1 to S-glutathionylation of endothelial nitric oxide synthase for mesenteric nitric oxide generation in experimental necrotizing enterocolitis

(2017) Qingjuan Shang et al.   Translational Research

Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction

(2017) B. Musicki et al.   Andrology

Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat

(2017) Mingming Liu et al.   Scientific Reports

Obesity-Related Perivascular Adipose Tissue Damage Is Reversed by Sustained Weight Loss in the RatHighlights

(2016) Charlotte E. Bussey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The transporter and permeability interactions of asymmetric dimethylarginine (ADMA) and L-arginine with the human blood–brain barrier in vitro

(2016) Christopher P. Watson et al.   BRAIN RESEARCH

Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of perivascular adipose tissue in obesity-induced vascular dysfunction

(2016) Ning Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting vascular (endothelial) dysfunction

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs

(2016) Emilio A. Herrera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK

(2016) Yan Chen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase

(2016) Anna Solini et al.   VASCULAR PHARMACOLOGY

Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats

(2016) B. Musicki et al.   Andrology

Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase

(2016) Chiao‐Po Hsu et al.   Journal of the American Heart Association

Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis

(2016) Kaisa M. Mäki‐Petäjä et al.   Journal of the American Heart Association

Different Anti-Contractile Function and Nitric Oxide Production of Thoracic and Abdominal Perivascular Adipose Tissues

(2016) Jamaira A. Victorio et al.   Frontiers in Physiology

Effects of Sapropterin on Portal and Systemic Hemodynamics in Patients With Cirrhosis and Portal Hypertension: A Bicentric Double-Blind Placebo-Controlled Study

(2015) Enric Reverter et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Rescue Treatment with L-Citrulline Inhibits Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs

(2015) Candice D. Fike et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Impact of eNOS-Dependent Oxidative Stress on Endothelial Function and Neointima Formation

(2015) Tatsiana Suvorava et al.   ANTIOXIDANTS & REDOX SIGNALING

Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis

(2015) Mattias Carlström et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants in Translational Medicine

(2015) Harald H.H.W. Schmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

AVE 3085, a novel endothelial nitric oxide synthase enhancer, attenuates cardiac remodeling in mice through the Smad signaling pathway

(2015) Yili Chen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endothelial Nitric Oxide Synthase–Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-NitrosylationSignificance

(2015) Zhejun Cai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Redox Regulation of Dihydrofolate Reductase: Figure.

(2015) Thomas Münzel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese MiceSignificance

(2015) Ning Xia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evidence for the free radical/oxidative stress theory of ageing from the CHANCES consortium: a meta-analysis of individual participant data

(2015) Ben Schöttker et al.   BMC Medicine

Arterial stiffness

(2015) Gary F. Mitchell   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

(2015) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease

(2015) Sebastian Steven et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

(2015) Yuliya Mikhed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Normal and high eNOS levels are detrimental in both mild and severe cardiac pressure-overload

(2015) Elza D. van Deel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure

(2015) Reza Aghamohammadzadeh et al.   JOURNAL OF VASCULAR RESEARCH

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury

(2014) Feng Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation

(2014) Francesco De Pascali et al.   BIOCHEMISTRY

Nighttime aircraft noise impairs endothelial function and increases blood pressure in patients with or at high risk for coronary artery disease

(2014) Frank Schmidt et al.   Clinical Research in Cardiology

eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation

(2014) Susanne Karbach et al.   CURRENT PHARMACEUTICAL DESIGN

Carbamylated low-density lipoprotein induces endothelial dysfunction

(2014) Thimoteus Speer et al.   EUROPEAN HEART JOURNAL

Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: role of perivascular adipose tissue

(2014) Agostino Virdis et al.   EUROPEAN HEART JOURNAL

Inflammatory Monocytes Determine Endothelial Nitric-oxide Synthase Uncoupling and Nitro-oxidative Stress Induced by Angiotensin II

(2014) Sabine Kossmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol and Endothelial Nitric Oxide

(2014) Ning Xia et al.   MOLECULES

Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1

(2014) Yan Sun et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Isoproterenol Induces Vascular Oxidative Stress and Endothelial Dysfunction via a Giα-Coupled β2-Adrenoceptor Signaling Pathway

(2014) Ana P. Davel et al.   PLoS One

Effects of Sapropterin on Endothelium-Dependent Vasodilation in Patients With CADASIL

(2014) Renata De Maria et al.   STROKE

Tetrahydrobiopterin in Cardiovascular Health and Disease

(2013) Jennifer K. Bendall et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species—Studies in White Blood Cells and in Animal Models

(2013) Swenja Kröller-Schön et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Ambient ultrafine particles reduce endothelial nitric oxide production via S-glutathionylation of eNOS

(2013) Yunfeng Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AT1 receptor blocker potentiates shear-stress induced nitric oxide production via modulation of eNOS phosphorylation of residues Thr495 and Ser1177

(2013) Valério G. Barauna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Redox Modulation of Endothelial Nitric Oxide Synthase by Glutaredoxin-1 through Reversible Oxidative Post-Translational Modification

(2013) Chun-An Chen et al.   BIOCHEMISTRY

Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCachannels and adiponectin

(2013) A H Weston et al.   BRITISH JOURNAL OF PHARMACOLOGY

cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue

(2013) Sarah B. Withers et al.   CARDIOVASCULAR RESEARCH

Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease

(2013) Huige Li et al.   CURRENT OPINION IN PHARMACOLOGY

Combination Pravastatin and Valsartan Treatment Has Additive Beneficial Effects to Simultaneously Improve Both Metabolic and Cardiovascular Phenotypes Beyond That of Monotherapy With Either Drug in Patients With Primary Hypercholesterolemia

(2013) K. K. Koh et al.   DIABETES

Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses

(2013) Bernardo J Krause et al.   Epigenetics

Efficacy of the long-acting nitro vasodilator pentaerithrityl tetranitrate in patients with chronic stable angina pectoris receiving anti-anginal background therapy with beta-blockers: a 12-week, randomized, double-blind, placebo-controlled trial

(2013) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults

(2013) F. P. Schmidt et al.   EUROPEAN HEART JOURNAL

Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis

(2013) S. Kaptoge et al.   EUROPEAN HEART JOURNAL

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutathione Peroxidase-1 Deficiency Potentiates Dysregulatory Modifications of Endothelial Nitric Oxide Synthase and Vascular Dysfunction in Aging

(2013) Matthias Oelze et al.   HYPERTENSION

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS)

(2013) Matthew A. Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Statins on Circulating Endothelial Progenitor Cells in Humans

(2013) Benjamin Hibbert et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Diabetes Mellitus-Associated Vascular Impairment

(2013) Dimitris Tousoulis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial Nitric Oxide Synthase Phosphorylation at Threonine 495 and Mitochondrial Reactive Oxygen Species Formation in Response to a High H2O2 Concentration

(2013) T.J. Guterbaum et al.   JOURNAL OF VASCULAR RESEARCH

Arginase: The Emerging Therapeutic Target for Vascular Oxidative Stress and Inflammation

(2013) Zhihong Yang et al.   Frontiers in Immunology

Comparison of Brachial Artery Wall Thickness Versus Endothelial Function to Predict Late Cardiovascular Events in Patients Undergoing Elective Coronary Angiography

(2012) Alois Suessenbacher et al.   AMERICAN JOURNAL OF CARDIOLOGY

Severe Life Stress and Oxidative Stress in the Brain: From Animal Models to Human Pathology

(2012) Stefania Schiavone et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Valor prognóstico da função endotelial em portadores de aterosclerose: revisão sistemática

(2012) Maristela Magnavita Oliveira Garcia et al.   Arquivos Brasileiros de Cardiologia

Simvastatin Reduces Myocardial Injury Undergoing Noncoronary Artery Cardiac Surgery

(2012) Mohammed Ahmed Saad Almansob et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial dysfunction in rheumatic autoimmune diseases

(2012) Giuseppe Murdaca et al.   ATHEROSCLEROSIS

Impairment of the extrusion transporter for asymmetric dimethyl-l-arginine: A novel mechanism underlying vasospastic angina

(2012) Ellen I. Closs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

B-type natriuretic peptide is an independent predictor of endothelial function in man

(2012) Maheshwar Pauriah et al.   CLINICAL SCIENCE

Uncoupling Endothelial Nitric Oxide Synthase Is Ameliorated by Green Tea in Experimental Diabetes by Re-establishing Tetrahydrobiopterin Levels

(2012) A. M. Faria et al.   DIABETES

Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression

(2012) Matthias Oelze et al.   EUROPEAN HEART JOURNAL

Multiple Endothelial Biomarkers and Noninvasive Vascular Function in the General Population

(2012) Renate B. Schnabel et al.   HYPERTENSION

Regulation of Endothelial Nitric-oxide Synthase (NOS)S-Glutathionylation by Neuronal NOS

(2012) Winifred O. Idigo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

(2012) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GBD 2010: design, definitions, and metrics

(2012) Christopher JL Murray et al.   LANCET

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Oxidative Stress-Induced Repression of Nrf2 and GSH Depletion: A Mechanism Potentially Involved in Endothelial Dysfunction of Young Smokers

(2012) Anna Fratta Pasini et al.   PLoS One

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

(2012) E. Choy   RHEUMATOLOGY

S-Glutathionylation Reshapes Our Understanding of Endothelial Nitric Oxide Synthase Uncoupling and Nitric Oxide/Reactive Oxygen Species-Mediated Signaling

(2011) Jay L. Zweier et al.   ANTIOXIDANTS & REDOX SIGNALING

Moderate Caveolin-1 Downregulation Prevents NADPH Oxidase–Dependent Endothelial Nitric Oxide Synthase Uncoupling by Angiotensin II in Endothelial Cells

(2011) Irina Lobysheva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nitroglycerin-Induced Endothelial Dysfunction and Tolerance Involve Adverse Phosphorylation and S -Glutathionylation of Endothelial Nitric Oxide Synthase

(2011) Maike Knorr et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparative assessment of vascular function in autoimmune rheumatic diseases: Considerations of prevention and treatment

(2011) Pál Soltész et al.   AUTOIMMUNITY REVIEWS

How to manage hypertension in pregnancy effectively

(2011) Laura A. Magee et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice

(2011) Yoshiko Tokutomi et al.   BRITISH JOURNAL OF PHARMACOLOGY

AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats

(2011) Qin Yang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats

(2011) Ken-ichi Serizawa et al.   Cardiovascular Diabetology

Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice

(2011) Wai San Cheang et al.   CARDIOVASCULAR RESEARCH

Nitrate Therapy

(2011) Thomas Münzel et al.   CIRCULATION

Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2011) Philip Wenzel et al.   CIRCULATION

Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

(2011) John W. Calvert et al.   CIRCULATION RESEARCH

Noninvasive Vascular Function Measurement in the Community

(2011) Renate B. Schnabel et al.   Circulation-Cardiovascular Imaging

Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy

(2011) S. Schuhmacher et al.   DIABETES

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nebivolol Exerts Beneficial Effects on Endothelial Function, Early Endothelial Progenitor Cells, Myocardial Neovascularization, and Left Ventricular Dysfunction Early After Myocardial Infarction Beyond Conventional β1-Blockade

(2011) Sajoscha A. Sorrentino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The biological effect of pharmacological treatment on dimethylaminohydrolases (DDAH-1) and cationic amino acid transporter-1 (CAT-1) expression in patients with acute congestive heart failure

(2011) Lorenza Speranza et al.   MICROVASCULAR RESEARCH

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1

(2010) Catherine A. Lemarié et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Psoriasis and cardiovascular disease

(2010) Gino A. Vena et al.   Dermatologic Therapy

Adaptative Nitric Oxide Overproduction in Perivascular Adipose Tissue during Early Diet-Induced Obesity

(2010) Marta Gil-Ortega et al.   ENDOCRINOLOGY

Is oxidative stress a therapeutic target in cardiovascular disease?

(2010) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Relationship of oxidative stress and endothelial dysfunction in sleep apnoea

(2010) B. Jurado-Gamez et al.   EUROPEAN RESPIRATORY JOURNAL

Pentaerythritol Tetranitrate Improves Angiotensin II–Induced Vascular Dysfunction via Induction of Heme Oxygenase-1

(2010) Swenja Schuhmacher et al.   HYPERTENSION

Inflammation, Immunity, and Hypertension

(2010) David G. Harrison et al.   HYPERTENSION

IL-17 in Systemic Lupus Erythematosus

(2010) José C. Crispín et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness

(2010) Anna Södergren et al.   ARTHRITIS RESEARCH & THERAPY

EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis

(2009) M J L Peters et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic lupus erythematosus and the risk of cardiovascular disease: Results from the nurses' health study

(2009) A. Elisabeth Hak et al.   ARTHRITIS AND RHEUMATISM

Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo

(2009) Travis W. Hein et al.   ATHEROSCLEROSIS

The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury

(2009) S. Frantz et al.   BASIC RESEARCH IN CARDIOLOGY

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

(2009) Dirk Westermann et al.   BASIC RESEARCH IN CARDIOLOGY

Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database

(2009) N. N. Mehta et al.   EUROPEAN HEART JOURNAL

Inhibition of platelet activation in rats with severe congestive heart failure by a novel endothelial nitric oxide synthase transcription enhancer

(2009) Andreas Schäfer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Tetrahydrobiopterin, superoxide, and vascular dysfunction

(2009) Jeannette Vásquez-Vivar   FREE RADICAL BIOLOGY AND MEDICINE

Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice With Angiotensin II–Induced Hypertension

(2009) Jian Xu et al.   HYPERTENSION

Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans

(2009) Robert D. Brook et al.   HYPERTENSION

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats

(2009) Jae Hyung Kim et al.   JOURNAL OF APPLIED PHYSIOLOGY

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

(2009) Annemarieke E. Loot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

(2009) Peter D. Gluckman et al.   Nature Reviews Endocrinology

Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design

(2009) H.-H. Parving et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes

(2008) Irina A. Ionova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

(2008) Thomas Münzel et al.   ANNALS OF MEDICINE

Nitric Oxide, Tetrahydrobiopterin, Oxidative Stress, and Endothelial Dysfunction in Hypertension

(2008) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction

(2008) Daniela Fraccarollo et al.   CIRCULATION

Epigenetic Regulation of Vascular Endothelial Gene Expression

(2008) Charles C. Matouk et al.   CIRCULATION RESEARCH

Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes

(2008) A. Riad et al.   DIABETOLOGIA

AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats

(2008) Philip Wenzel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCɛ signaling axis in pulmonary artery smooth muscle cells

(2008) R RATHORE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

(2008) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis

(2008) DD Balci et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Homocysteine decreases platelet NO level via protein kinase C activation

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