Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Wojciech Myslinski
Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.
Article
Biochemistry & Molecular Biology
Priscilla Bianca de Oliveira, Gabriela Palma Zochio, Edileia Souza Paula Caetano, Maria Luiza Santos da Silva, Carlos Alan Dias-Junior
Summary: The study investigated the role of perivascular adipose tissue (PVAT)-derived hydrogen sulfide (H2S) in vasodilation in pregnancy hypertension-induced endothelial dysfunction. The results showed that PVAT-derived H2S stimulated with the amino acid L-cysteine may be an alternative method to induce vasorelaxation in endothelial dysfunction related to pregnancy hypertension.
Article
Pharmacology & Pharmacy
Hong Shi, Hanping Wu, Michael A. Winkler, Eric J. Belin de Chantemele, Richard Lee, Ha Won Kim, Neal L. Weintraub
Summary: This review article discusses the link between perivascular adipose tissue (PVAT) and the pathogenesis of cardiovascular disease (CVD) in patients with autoimmune rheumatic diseases (ARDs). The research suggests that inflammation within PVAT may contribute to the development of CVD. Novel PVAT imaging techniques can help define disease risk and evaluate responses to biological therapies.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Yusuke Adachi, Kazutaka Ueda, Eiki Takimoto
Summary: Perivascular adipose tissue (PVAT), the adipose tissue surrounding blood vessels, may play a crucial role in the pathogenesis of cardiovascular disease. It can potentially release inflammatory mediators and contribute to vascular pathologies under pathological conditions, while having a vasculo-protective function in a healthy state. Recent research using integrative omics approaches has advanced our understanding of the molecular mechanisms and potential therapeutic applications of PVAT in atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
Celestina Mazzotta, Sanchita Basu, Adam C. Gower, Shakun Karki, Melissa G. Farb, Emily Sroczynski, Elaina Zizza, Anas Sarhan, Ashvin N. Pande, Kenneth Walsh, Nikola Dobrilovic, Noyan Gokce
Summary: This study identifies an inflamed region in perivascular adipose tissue (PVAT) associated with atherosclerosis, with higher inflammation levels in obese individuals. Dysfunctional PVAT may contribute to vascular disease mechanisms, especially in the context of obesity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Yaozhi Chen, Zeyu Qin, Yaqiong Wang, Xin Li, Yang Zheng, Yunxia Liu
Summary: Perivascular adipose tissue (PVAT) provides mechanical support and maintains vascular homeostasis under normal conditions, but dysfunction of PVAT may lead to vascular inflammation and diseases in pathological conditions. The pro-inflammatory crosstalk between PVAT and blood vessels could serve as a novel therapeutic target for the prevention and treatment of vascular diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Hong Shi, Brandee Goo, David Kim, Taylor C. Kress, Mourad Ogbi, James Mintz, Hanping Wu, Eric Belin J. de Chantemele, David Stepp, Xiaochun Long, Avirup Guha, Richard Lee, Laura Carbone, Brian H. Annex, David Y. Hui, Ha Won Kim, Neal L. Weintraub
Summary: Patients with systemic lupus erythematosus (SLE) are at elevated risk for cardiovascular disease (CVD) due to accelerated atherosclerosis. Compared to heathy control subjects, lupus patients have higher volumes and densities of thoracic aortic perivascular adipose tissue (PVAT), which independently associates with vascular calcification, a marker of subclinical atherosclerosis. However, the biological and functional role of PVAT in SLE has not been directly investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Christos P. Kotanidis, Charalambos Antoniades
Summary: Advances in technology, computation, and research have revolutionized the field of medical imaging, particularly in cardiovascular non-invasive imaging. Perivascular adipose tissue (PVAT), a diverse structure surrounding human vessels, plays a key role in vascular inflammation through its rich secretome and bidirectional interaction with the vascular wall. This review discusses the current status of cardiac CT in imaging vascular inflammation through PVAT phenotyping.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjuan Mu, Shuwen Qian, Yanjue Song, Lijie Yang, Saisai Song, Qiqi Yang, Hao Liu, Yang Liu, Dongning Pan, Yan Tang, Qi-Qun Tang
Summary: Loss of bone morphogenetic protein 4 (BMP4) in perivascular adipose tissue (PVAT) leads to reduced brown adipocyte-characteristic gene expression and increased endothelial inflammation, exacerbating atherosclerosis in ApoE-/- mice. Conversely, overexpression of BMP4 in adipose tissues promotes browning of PVAT and protects against atherosclerosis. These findings highlight the importance of organ crosstalk between PVAT and blood endothelial cells in the development of atherosclerosis.
Article
Engineering, Biomedical
Yinggang Wang, Mingdi Fu, Weiwei Xiao, Yajing Zhao, Pingping Yuan, Xinchi Zhang, Wei Wu
Summary: Arterial injuries often lead to perivascular tissue damage, resulting in high failure rates of vein grafts. This study used a perivascular tissue deprivation animal model to mimic clinical scenarios and investigate the role of perivascular tissue in the success of vein grafts. The analysis suggests that perivascular tissue deprivation exacerbates oxidative stress and inflammation, leading to endothelial apoptosis and acute thrombosis. However, locally administering metformin through a 3D-printed external stent protects the vein grafts and improves patency by inhibiting apoptosis, reducing oxidative stress, and promoting regeneration of perivascular adipose tissue.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chak Kwong Cheng, Huanyu Ding, Minchun Jiang, Huiyong Yin, Maik Gollasch, Yu Huang
Summary: Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT is actively involved in the regulation of reactive oxygen species (ROS) homeostasis and inflammation in the vascular system. The phenotype-genotype of PVAT varies in different regions of the vasculature and plays a role in cardiovascular pathogenesis. Treatments targeting PVAT may provide new therapeutic insights for cardiovascular diseases.
Review
Immunology
Meichao Cai, Dongsheng Zhao, Xiao Han, Shuang Han, Wenxin Zhang, Zhennan Zang, Chenchen Gai, Rong Rong, Tian Gao
Summary: Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The interaction between them is of great value for the assessment of vascular inflammation and cardiovascular ischemic disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ayumu Osaki, Kazuki Kagami, Yuki Ishinoda, Atsushi Sato, Toyokazu Kimura, Shunpei Horii, Kei Ito, Takumi Toya, Yasuo Ido, Takayuki Namba, Nobuyuki Masaki, Yuji Nagatomo, Takeshi Adachi
Summary: Metabolic syndrome is a major contributor to metabolic complications and cardiovascular diseases. This study evaluated the effects of additional factors such as diabetes, dyslipidemia, and steatohepatitis on endothelial dysfunction in aortas. The results showed that these factors can impair the endothelial function of aortas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Yuehan Wang, Xutao Zhang, Chunxiu Zhou, Haroon Khan, Manqin Fu, Wai San Cheang
Summary: The study found that CRP extract has a protective effect on endothelial function and inflammation in type 2 diabetic rats. It can normalize blood pressure, plasma lipid profile, and liver enzyme levels, improve endothelium-dependent relaxations in arteries, suppress vascular inflammatory markers, and activate AMPK. In experiments, co-incubation of CRP extract with high glucose prevented the impairment of vasodilation.
Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)