Developments with 3D bioprinting for novel drug discovery

3D bioprinted functional and contractile cardiac tissue constructs

(2018) Zhan Wang et al.   Acta Biomaterialia

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

(2018) Xuanyi Ma et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidics-Enabled Multimaterial Maskless Stereolithographic Bioprinting

(2018) Amir K. Miri et al.   ADVANCED MATERIALS

Rerouting mesenchymal stem cell trajectory towards epithelial lineage by engineering cellular niche

(2018) Ananya Barui et al.   BIOMATERIALS

Essential steps in bioprinting: From pre- to post-bioprinting

(2018) Pallab Datta et al.   BIOTECHNOLOGY ADVANCES

Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and artificial intelligence?

(2018) Edward J. Griffen et al.   DRUG DISCOVERY TODAY

Reshaping drug development using 3D printing

(2018) Atheer Awad et al.   DRUG DISCOVERY TODAY

3D bioprinting of a corneal stroma equivalent

(2018) Abigail Isaacson et al.   EXPERIMENTAL EYE RESEARCH

Introduction to biological complexity as a missing link in drug discovery

(2018) Gary A. Gintant et al.   Expert Opinion on Drug Discovery

3D-printed miniaturized fluidic tools in chemistry and biology

(2018) C.K. Dixit et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

3D Printing Pharmaceuticals: Drug Development to Frontline Care

(2018) Sarah J. Trenfield et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bioprinting of 3D tissues/organs combined with microfluidics

(2018) Jingyun Ma et al.   RSC Advances

Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models

(2018) Chya-Yan Liaw et al.   Advanced Healthcare Materials

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Human tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection

(2018) D. Gholobova et al.   Scientific Reports

Bioprinting of biomimetic skin containing melanocytes

(2017) Daejin Min et al.   EXPERIMENTAL DERMATOLOGY

Generation of Multilayered 3D Structures of HepG2 Cells Using a Bio-printing Technique

(2017) Hyeryeon Jeon et al.   Gut and Liver

Engineering muscle cell alignment through 3D bioprinting

(2017) Pamela Mozetic et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury

(2017) Gaurav Agrawal et al.   LAB ON A CHIP

3D modeling of cancer stem cell niche

(2017) Jun He et al.   Oncotarget

Concise Review: Bioprinting of Stem Cells for Transplantable Tissue Fabrication

(2017) Ashley N. Leberfinger et al.   Stem Cells Translational Medicine

Microfluidic Technology for the Generation of Cell Spheroids and Their Applications

(2017) Raja Vadivelu et al.   Micromachines

3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing

(2017) Shelby M. King et al.   Frontiers in Physiology

High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing

(2017) Alexander D. Graham et al.   Scientific Reports

3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study

(2016) Xuan Zhou et al.   ACS Applied Materials & Interfaces

Big data to smart data in Alzheimer's disease: The brain health modeling initiative to foster actionable knowledge

(2016) Hugo Geerts et al.   Alzheimers & Dementia

A comprehensive review on droplet-based bioprinting: Past, present and future

(2016) Hemanth Gudapati et al.   BIOMATERIALS

Current advances and future perspectives in extrusion-based bioprinting

(2016) Ibrahim T. Ozbolat et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

Leveraging big data to transform target selection and drug discovery

(2016) B Chen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Application areas of 3D bioprinting

(2016) Ibrahim T. Ozbolat et al.   DRUG DISCOVERY TODAY

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Phase II and phase III failures: 2013–2015

(2016) Richard K. Harrison   NATURE REVIEWS DRUG DISCOVERY

Managing risks in drug discovery: reproducibility of published findings

(2016) Aimo Kannt et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Rho-Associated Protein Kinase Increases the Angiogenic Potential of Mesenchymal Stem Cell Aggregates via Paracrine Effects

(2016) Soyoung Hong et al.   TISSUE ENGINEERING PART A

Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

(2016) Weijie Peng et al.   TRENDS IN BIOTECHNOLOGY

3D Cell Printing of Functional Skeletal Muscle Constructs Using Skeletal Muscle-Derived Bioink

(2016) Yeong-Jin Choi et al.   Advanced Healthcare Materials

Microfluidic-Based Multi-Organ Platforms for Drug Discovery

(2016) Ahmad Rezaei Kolahchi et al.   Micromachines

Novel Compound-Forming Technology Using Bioprinting and Electrospinning for Patterning a 3D Scaffold Construct with Multiscale Channels

(2016) Yuanshao Sun et al.   Micromachines

3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking

(2016) Liliang Ouyang et al.   ACS Biomaterials-Science & Engineering

3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking

(2016) Liliang Ouyang et al.   ACS Biomaterials Science & Engineering

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

(2016) Deborah G. Nguyen et al.   PLoS One

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

3D bioprinting of biomimetic aortic vascular constructs with self-supporting cells

(2015) Can Kucukgul et al.   BIOTECHNOLOGY AND BIOENGINEERING

Functional protein micropatterning for drug design and discovery

(2015) Changjiang You et al.   Expert Opinion on Drug Discovery

Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture

(2015) K. C. Hribar et al.   LAB ON A CHIP

Cell viability assessment using the Alamar blue assay: A comparison of 2D and 3D cell culture models

(2015) F. Bonnier et al.   TOXICOLOGY IN VITRO

A spheroid toxicity assay using magnetic 3D bioprinting and real-time mobile device-based imaging

(2015) Hubert Tseng et al.   Scientific Reports

Recent advances in 3D printing of biomaterials

(2015) Helena N Chia et al.   Journal of Biological Engineering

Bioprinting-Based High-Throughput Fabrication of Three-Dimensional MCF-7 Human Breast Cancer Cellular Spheroids

(2015) Kai Ling et al.   Engineering

Engineering an in vitro air-blood barrier by 3D bioprinting

(2015) Lenke Horváth et al.   Scientific Reports

Consideration of the cellular microenvironment: Physiologically relevant co-culture systems in drug discovery

(2014) Ellen L. Berg et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Role of Notch signaling in the mammalian heart

(2014) X.L. Zhou et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Three-dimensional printing of Hela cells for cervical tumor modelin vitro

(2014) Yu Zhao et al.   Biofabrication

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels

(2014) Luiz E Bertassoni et al.   Biofabrication

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

3Din vitrotissue models and their potential for drug screening

(2013) Lauren Kimlin et al.   Expert Opinion on Drug Discovery

Bioprinting Toward Organ Fabrication: Challenges and Future Trends

(2013) I. T. Ozbolat et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Patient-Specific Stem Cells and Cardiovascular Drug Discovery

(2013) Nicholas M. Mordwinkin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cellular behavior in micropatterned hydrogels by bioprinting system depended on the cell types and cellular interaction

(2013) Soyoung Hong et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Three-dimensional cell culturing by magnetic levitation

(2013) William L Haisler et al.   Nature Protocols

Design and Fabrication of Human Skin by Three-Dimensional Bioprinting

(2013) Vivian Lee et al.   TISSUE ENGINEERING PART C-METHODS

Synthesis and characterization of a novel poly(vinyl alcohol) 3D platform for the evaluation of hepatocytes' response to drug administration

(2013) Alessandra Stampella et al.   Journal of Materials Chemistry B

Gravity-oriented microfluidic device for uniform and massive cell spheroid formation

(2012) Kangsun Lee et al.   Biomicrofluidics

Improving piezoelectric cell printing accuracy and reliability through neutral buoyancy of suspensions

(2012) Daljeet Chahal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Skin tissue generation by laser cell printing

(2012) Lothar Koch et al.   BIOTECHNOLOGY AND BIOENGINEERING

Accelerated myotube formation using bioprinting technology for biosensor applications

(2012) Xiaofeng Cui et al.   BIOTECHNOLOGY LETTERS

Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

(2012) Henning Karlsson et al.   EXPERIMENTAL CELL RESEARCH

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

High throughput miniature drug-screening platform using bioprinting technology

(2012) Jorge I Rodríguez-Dévora et al.   Biofabrication

Bio-ink for on-demand printing of living cells

(2012) Cameron J. Ferris et al.   Biomaterials Science

A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform

(2011) Feng Xu et al.   Biotechnology Journal

Vasculogenesis: a new piece of the endometriosis puzzle

(2011) M.W. Laschke et al.   HUMAN REPRODUCTION UPDATE

Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip

(2011) J E Snyder et al.   Biofabrication

Cell-based assays: fuelling drug discovery

(2010) Elisa Michelini et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells

(2010) Xiaofeng Cui et al.   BIOTECHNOLOGY AND BIOENGINEERING

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Three-dimensional tissue culture based on magnetic cell levitation

(2010) Glauco R. Souza et al.   Nature Nanotechnology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Laser-based direct-write techniques for cell printing

(2010) Nathan R Schiele et al.   Biofabrication

A Piezoactuated Droplet-Dispensing Microfluidic Chip

(2009) Mohammed Jalal Ahamed et al.   JOURNAL OF MICROELECTROMECHANICAL SYSTEMS

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE