Journal
ONCOTARGET
Volume 9, Issue 1, Pages 1326-1345Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19847
Keywords
cancer stem cells; niche; 3D models
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Funding
- National Natural Science Foundation of China [81472738, 81472496, 81372628, 81402536, 31571241, 31660266]
- Planned Science and Technology Project of Hunan Province [2015GK3117, 2014WK2016]
- Changsha Science and Technology Plan Project [K1205018-31]
- Innovation Project of Ministry of Science and Technology [X8C1Y0K9]
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Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These in vitro culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites.
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